Dermatopathology Institute
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Unknown Slide Review
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Featured Article
Many of you enjoyed our recent case presentation illustrating the travails of utilizing multiple consultants. Here, by request, is the case study that generated a very lively discussion at a recent hospital talk.

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 March 2009



It was wonderful meeting so many of you at our recent hospital and community presentations. If there are topics that you would like to see covered in our newsletters, please do not hesitate to contact us.

Please check out our new section, Dermatopathology Differential Diagnosis.

We would like to update and alert you to these two newly described entities which the Institute has published.

Discohesive Malignant Melanoma Simulating a Bullous Dermatoses. J Cutan Pathol 2009;Feb 36(2): 274-279

This variant of melanoma, described by us, demonstrates the sometimes difficult task of separating neoplastic processes from inflammatory. The melanomas in our series resembled pemphigus vegetans and pemphigus vulgaris.

Amelanotic Malignant Melanoma in Situ: A Histopathologic Mimic of Benign Skin Lesions. Presented at the International Society of Dermatopathology Annual Meeting. March 5, 2009. San Francisco.

This new variant of melanoma in situ was just reported by us at the recent International Society of Dermatopathology. We identified 10 cases after a retrospective review of 444 cases of melanoma in situ (lentigo maligna). While the epidemiological profile is similar to other cases of lentigo maligna, in only 3 of the cases was a diagnosis of lentigo maligna suspected. On histopathological examination, the junctional melanocytes were small and had little to absent melanin pigment. The diagnosis was confirmed by staining with the Melan-A antibody.

Thank you.
The Dermatopathology Institute
Unknown Slide Reviews
Urticaria Unknown Slide Review Part 25

Test your diagnostic acumen with this review of interesting cases from this past week's signout.

What is this dermatitis that presents with subtle histopathological changes, raising the differential diagnosis of an "invisible dermatosis"?
Unknown Slide Reviews

Dermatopathology Slide Atlas

Diagnostic Pearls from the Dermatopathology Literature
Although this is a rare tumor, it is important to distinguish this from its histologic mimic, Langerhans cell tumors. Recent studies suggest an important to link to B-cell nodal and systemic lymphomas. Histopathologists should also consider adding Langerin to their immunohistochemical panel of Langerhans cells.
If you would like one of our dermatopathologists to give a talk to your office or facility, please contact us directly.

Thank you!

Paul K. Shitabata, M.D.
President and Medical Director
Dermatopathology Institute
Director of Dermatopathology, Harbor-UCLA Dermatology