George Singleton has published short stories in a variety of magazines and journals including The Atlantic Monthly, Harper's Playboy, Zoetrope, The Georgia Review, Shenandoah, Southern Review, Kenyon Review, Glimmer Train, North American Review, Fiction International, Epoch, Esquire.com, Nw England Review, Carolina Quarterly, Greensboro Review, Arkansas Review, American Literary Review, and so on. His stories have been anthologized in eight issues of New Stories from the South, and also in 20 Over 40, Surreal South, Writers Harvest 2, They Write Among Us, and Behind the Short Story. His non-fiction has appeared in Bark and Oxford American, and has been anthologized in Best Food Writing 2005, Dog is My Co-Pilot, and Howl. He has published four collections of stories: These People Are Us, The Half-Mammals of Dixie, Why Dogs Chase Cars, Drowning in Gruel; and two novels: Novel and Work Shirts for Madmen.

George was born in Anaheim, California and lived there until he was seven. He grew up in Greenwood, South Carolina. He graduated from Furman University in 1980 with a degree in philosophy, and from UNC-Greensboro with an MFA in creative writing. Singleton has taught English and fiction writing at Francis Marion College, the Fine Arts Center of Greenville County, and the South Carolina Governor's School for the Arts and Humanities. He has been a visiting professor at the University of South Carolina and UNC-Wilmington, and has given readings and taught classes at a number of universities and secondary schools.

His papers are reposited at the Jackson Library at the University of North Carolina at Greensboro.

He lives in Pickens County, South Carolina, with the clay artist Glenda Guion and their eleven dogs and one cat.