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TTO Monthly Newsletter

Volume 8 ~ Issue 5 ~ January 2012       

What's Inside
Tech Spotlight
Recently at TTO
CU Technology in the News
People
Upcoming Events
Innovation in the News
External Resources
Parting Quote
Links

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Spotlight On:

Biotechnology of the Month:

 

Intra-cardiac Camera System for Improved Cardiac Visualization in Humans and Animals 

 

Physical Sciences Tech of the Month:

 

Improved Micro Cryogenic Cooler 

 

 

*To view more CU technologies available for licensing and partnering, go to Tech Explorer.

Recently at TTO

CU Announces Annual Technology Transfer Awards 

TTO hosted its 10th annual awards ceremony this week, honoring several faculty researchers, two companies founded on university research, and several members of the local entrepreneurial community. "The University of Colorado is a primary driver for the Colorado economy in many ways - one way that is often less visible than our thousands of graduates, new buildings and faculty accolades is the commercialization of research," said David Allen, associate vice president for technology transfer at CU. "This event recognizes excellence in the people and licensee companies that exemplify CU's success in transforming research into real-world impact." This year's award winners include:

 

Jeffrey L. Olson, Inventor of the Year, CU Denver | Anschutz Medical Campus. Olson, an associate professor of ophthalmology, specializes in the medical and surgical management of retinal diseases like macular degeneration, diabetic retinopathy and retinal detachment. One of his inventions, a  method for preserving eyesight through the use of nanotechnology, is licensed to a CU startup currently raising Series A financing.

 

Linda R. Watkins, Inventor of the Year, CU-Boulder. Watkins, a distinguished professor of psychology, has developed both novel drugs and new uses of known drugs targeting various disorders with unmet medical needs, including chronic and neuropathic pain, multiple sclerosis, ALS and addiction. Her inventions have led to numerous industry collaborations and licenses, as well as the formation of a new company, Xalud Therapeutics.

 

Richard J. Johnson, New Inventor of the Year, CU Denver | Anschutz Medical Campus. Johnson is chief of the division of renal diseases and hypertension; his research has focused on the mechanisms of renal injury and progression, including in diabetes and hypertension. Recent work has also examined the role of uric acid and fructose in obesity, metabolic syndrome, diabetes and hypertension.

 

Wei Zhang, New Inventor of the Year, CU-Boulder. Zhang, an assistant professor of chemistry & biochemistry, is developing novel materials with potential applications in solar energy conversion, gas separation and storage, chemical sensing and catalysis.

 

Anatoliy O. Pinchuk, New Inventor of the Year, CU-Colorado Springs. Pinchuk is an assistant professor of physics and energy science; his research focuses on nano-materials for intracellular imaging and optical bio-chemical sensors.     

 

OPX Biotechnologies, Bioscience Company of the Year. OPXBIO (Boulder, CO) is a venture-backed company making renewable bio-based chemicals and fuels that are lower cost, higher return and more sustainable than existing petroleum-based products.

 

Phobos Energy, Physical Sciences/Engineering/IT Company of the Year. Phobos Energy (Menlo Park, CA; Lafayette, CO) is focused on increasing energy production, decreasing costs, and opening up new applications for solar photovoltaic power production.    

 

S. Gail Eckhardt, Business Advisor of the Year. Eckhardt is chief of the division of medical oncology at the Anschutz Medical Campus. As an advisor to TTO on drug discovery and development projects, she has been critically important in facilitating industry collaborations involving not just her lab, but labs of her CU collaborators.    

 

Michael R. Bristow, Serial University Start-up Entrepreneur Award. Bristow, a professor of medicine (division of cardiology) at the Anschutz Medical Campus, was a founder and former chief science and medical officer of Myogen, Inc. (acquired by Gilead Sciences, Inc. in 2006). He is the President and CEO of ARCA biopharma (Broomfield, CO), a company he founded in 2003 with the goal of developing genetically targeted therapies for heart failure. In 2007 he co-founded miRagen Therapeutics, (Boulder, CO), a company dedicated to utilizing the biologic properties of microRNAs in developing therapies for cardiovascular diseases.      

 

Additionally, two CU researchers were inducted into the Pinnacles of Inventorship, an all-stars group recognizing continuous commitment to best practices in technology transfer: Kristi S. Anseth (Distinguished Professor of Chemical and Biological Engineering, CU-Boulder) and Charles A. Dinarello (Professor of Medicine and Immunology, Anschutz Medical Campus).

 

MediciNova and CU Collaborate on Potential Therapy for Traumatic Brain Injury 

MediciNova, Inc., a biopharmaceutical company that is publicly traded on the Nasdaq Global Market (Trading Symbol: MNOV) and the Jasdaq Market of the Osaka Securities Exchange (Code Number: 4875), and the University of Colorado (CU) Boulder disclosed a license agreement for the use of ibudilast (MN-166/AV411) for the treatment of post-traumatic brain injury (TBI). Led by the research of Daniel Barth, Ph.D., Professor of Neuroscience and Psychology at CU-Boulder, ibudilast demonstrated significant efficacy in a model of post-TBI anxiety, one of the most common disorders caused by TBI. Traumatic brain injury (TBI) is a major public health concern, with approximately 1.7 million people in the United States alone sustaining a TBI each year. The long-term consequences of TBI include neuropsychiatric disorders, of which anxiety disorders are the most prevalent. (Read the full release.)

 

State of Colorado Announces January 31 Deadline for Early-Stage Company Grants 

The Colorado Office of Economic Development & International Trade is now accepting applications for its Bioscience Discovery Evaluation Grant (BDEG) Early Stage Company Grants, which are intended to spur economic development and help new companies born out of Colorado research institutions succeed in developing new technologies, business structures, and products. Eligibility, guidelines and applications are available online.

 

Call for Posters: CU-Boulder Save the Date: Entrepreneurship Under the Microscope

On March 14, TTO (with the Deming Center for Entrepreneurship) will host this annual event recognizing and celebrating innovation and commercialization around the CU-Boulder campus and beyond. The event will include a poster session presenting CU-Boulder technologies that are ready to take the next step toward commercialization - please email us if your lab would like to participate in the poster session.

CU Technology and Licensee Companies in the News

Omni Bio to Conduct New Human Clinical Trials

CU licensee Omni Bio Pharmaceutical, a clinical-stage biopharmaceutical company, announced its intention to commence new human clinical trials to test the efficacy of Alpha-1 antitrypsin (AAT) as a treatment in Type 1 diabetes and graft versus host disease (GVHD). Omni Bio intends to commence a placebo-controlled Type 1 diabetes human clinical trial in recently diagnosed juvenile subjects. The Company also plans to initiate a proof of principle human clinical trial for the treatment of lethal complication of bone marrow transplantation, also known as GVHD.

 

ARCA Receives Patent for Heart Drug

CU licensee ARCA biopharma received a new patent for its genetic targeting method to treat patients with its heart disease drug Gencaro. Now that it has the new patent from the U.S. Patent and Trademark Office, Broomfield-based ARCA plans to raise new money to pay for a Phase 3 clinical trial to test the atrial fibrillation drug. (See also: ARCA Raising Capital Through Stock Sale.)

 

Clarimedix, Inc. Secures Investment for Proof-of-Concept Study in Cerebral Vasospasm

Clarimedix, Inc., a CU licensee focused on the development of non-invasive therapeutics for the treatment of disorders associated with vascular dysfunction, announced that an investment has been secured from the Johnson & Johnson Corporate Office of Science and Technology (COSAT). The funds will be used for a human proof-of-concept study to determine the viability of Clarimedix's product for cerebral vasospasm.

 

Louisiana Assisting Sundrop Fuels with Biofuels Project

CU licensee Sundrop Fuels, a Colorado-based renewable fuels company, plans to build its $450M plant north of Alexandria with help from the state of Louisiana. Louisiana taxpayers will fund $4.5 million to help with the costs of moving Sundrop's research and development department to Alexandria, and give performance-based grants totaling $14 million over 10 years based on employment figures.

 

CU Study Examines Drug Resistance in ALK-positive Lung Cancer

Scientists from the University of Colorado Cancer Center (UCCC) have advanced the treatment of a specific kind of lung cancer. The team has documented how anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC) becomes resistant to a drug targeting the abnormal protein in the cancer. It's the first time scientists have analyzed the frequency and type of drug resistance in ALK positive patients taking crizotinib.

CU Denver Study Pinpoints and Plugs Mechanism of AML Cancer Cell Escape 

A recent CU study identifies a mechanism that acute myeloid leukemia (AML) cells use to evade chemotherapy - and details how to close this escape route. "Introducing chemotherapy to cells is like putting a curve in front of a speeding car," says Christopher Porter, investigator at the University of Colorado Cancer Center (UCCC) and assistant professor of pediatrics at the University of Colorado School of Medicine. "Cells that can put on the brakes make it around the corner and cells that can't speed off the track."

People

 Margaret Murnane Appointed Chairman of President's Committee on the National Medal of Science 

President Obama appointed CU Distinguished Professor of Physics Margaret Murnane as Chairman, President's Committee on the National Medal of Science. Murnane is a Fellow of JILA (a joint institute of CU and NIST), and a co-founder of CU licensee KMLabs.

 

Colorado Technology Association Selects New Leadership to Advance Colorado's Tech Community

The Colorado Technology Association (CTA) named Steve Foster as the new President and CEO of the Association, and announced Bill Soards President of AT&T Colorado as the new 2012 Board Chair. In addition, the Board of Directors elected two state legislative leaders to be on the board, including State Senator Michael Johnston and House Majority Leader Amy Stephens.

 

Do you know of a recent award, new position or transition of interest to the CU tech community? Please send information to TTOnews@cu.edu.

Upcoming Events

The Fine Details of Seed Capital for Startups 

January 23, CREED Center, Golden

Do you need a sound strategy for raising capital for your startup? Join the Colorado Association for Manufacturing and Technology (CAMT) to de-mystify the investment process and get an inside look at how seed investors think and operate.

 

TTO Public Event: Tech Transfer at the University of Colorado 

January 24, Location TBA

To some, tech transfer seems like a "black box" - investigators conduct research and report inventions, a percentage of the inventions are protected through the patent process, some of the protected assets are licensed, some products are developed, some are sold commercially and sometimes the University receives royalties and other economic consideration. During this session we will peer into the black box to see how policies, procedures and practices at CU and TTO address the throughput of inventions to royalties, and how various internal and external groups play a role in making this happen. Participants will become better informed about technology transfer and will devise ways to engage in and/or advise on the process. This event is free and open to the public. Please RSVP to Lynn Pae via email or at 303-735-0550.

 

CREED Entrepreneur Series: Financing Your Cleantech Startup 

January 26, CREED Center, Golden

The funding process is complex and the hurdles are high - join the Colorado Center for Renewable Energy Economic Development (CREED) for an overview of how to find capital for your cleantech startup from Tim Reeser, Executive Director Cenergy and Venture Director at Aravaipa Ventures.

 

Bioscience Day at the Capitol 

February 2, Capitol Building, Denver

Join the Colorado BioScience Association (CBSA) in celebrating the bioscience industry and learn about the accomplishments and discoveries made in our state.

 

Boulder/Denver New Technology Meetup 

February 7, CU-Boulder

This ongoing event provides a forum for technologists and entrepreneurs to showcase the new (especially web-based) technology developing in Boulder/Denver tech community. Five companies have five minutes each to demonstrate their new technology, followed by five minutes for Q&A from the audience.

 

EPIIC Nights: Michael Robertson 

February 13, CU-Colorado Springs

The second in an ongoing series of speakers hosted by the El Pomar Institute for Innovation and Commercialization (EPIIC).

 

NVC Crash Course: Guerilla PR for Startups

February 20, CU-Boulder

Guerilla PR for Startups: how to's, how don'ts and lessons from the front lines. This crash course is a great resource for people trying to launch brands and products and will include practical and real world advice. Part of the CU New Venture Challenge (NVC).

 

Save the Date: RETool: Developing Business & Careers in the New Energy Economy 

Focused on a clean-energy future? Get ahead of the curve and take RETool: a 4-day executive education certificate program hosted by the Deming Center for Entrepreneurship and the Renewable and Sustainable Energy Institute (RASEI) at CU-Boulder. RETool provides a deep-dive short course for individuals seeking to "retool" their skills to enter the clean energy field, as well as for businesses seeking new opportunities in cleantech. Remaining 2012 spring sessions (may be attended individually):

 

Friday, February 24: Clean Energy Policies

Friday, March 23: The Business of Clean Energy

Friday, April 13: Clean Energy Integration & the Future


Save the Date: Entrepreneurship Under the Microscope

March 14, CU-Boulder

Join the CU Tech Transfer Office and the Leeds School of Business' Deming Center for Entrepreneurship  in recognizing and celebrating innovation and commercialization around the CU-Boulder campus and beyond. Meet and network with students, faculty, staff, alumni, administration, and business community members. Hear from today's movers about big (and small) ideas in today's most interesting and exciting sectors.

This event will include a poster session presenting CU-Boulder technologies that are ready to take the next step toward commercialization (email us if you'd like to participate in the poster session).

 

To have your event featured here, please send an email to TTOnews@cu.edu.

Innovation in the News

Colorado Tech Initiatives Highlighted in SSTI Legislative Action Report 

Several Colorado legislative and executive initiatives were featured in Tech-based Economic Development and the States: Legislative Action in 2011 (PDF), a report assembled by the State Science & Technology Institute (SSTI). The report included four Colorado tech initiatives:

 

House, Senate Agree to Six-Year SBIR Reauthorization 

The Small Business Innovation Research (SBIR) program was reauthorized for six years under a decision reached the Senate and House of Representatives in December. Established in 1982 with its companion Small Business Technology Transfer (STTR), SBIR assists some 6,000 companies a year. Yet until now, it has subsisted on the same $2.2B annual budget it had when its authorization ended with the 2008 fiscal year thanks to 13 stopgap continuing resolutions (CRs). The reauthorized SBIR would raise the percentage that agencies would have to set aside for SBIR/STTR, as well as raising the maximum amount of grant funding for awardees for the first time since 1982, from $100,000 to $150,000 for Phase I and from $750,000 to $1 million for Phase II.

 

America COMPETES Report Emphasizes Innovative Research, Education, Infrastructure
U.S. Secretary of Commerce John Bryson recently presented the key findings of a year-long study into the challenges and opportunities facing the national innovation economy (full video of the event is available at the
Center for American Progress site). Over the past decade, a number of warning signs have indicated that the U.S. is en route to a less dominant position in the global economy. The Department of Commerce (DOC) report focuses on the need for the federal government to collaborate with the private sector to increase research spending, improve STEM education and revitalize manufacturing.

 

Biotech Startups Rely on Different Types of Funding 

Biotechnology startups across the country are using novel sources of funding. "Private investment is waning for early stage investment," says Rick Silva, director of the University of Colorado Technology Transfer Office. "Universities have been pulled into the realm of technology maturation to fill a void in early stage investing."

 

Roundup: University, Community, State, National and International Initiatives

 

Cleveland Clinic Innovations Receives Unexpected $10M Donation for Medical Innovation  A West Virginia businessman confirmed a $10M donation to Cleveland Clinic Innovations last month; the gift will be used to establish a chair in medical innovation, to fund patent applications and to provide space and seed funding to early stage businesses.

 

Idaho Governor Announces $5M Industry-University Research Partnership 

Gov. Butch Otter unveiled plans for a targeted partnership among industry, higher education and government that invests in R&D to produce new technologies - and ultimately - jobs. The governor is asking lawmakers to approve $5 million for startup costs in the FY13 budget.

External Resources

2012 R&D Gains for Basic Research, Energy, and Environment; Overall Investment Down 

Basic and applied research and energy and environmental research scored significant increases in a 2012 budget bill signed recently by President Barack Obama, but overall research and development spending will decline by 1.3%, according to a new analysis by the American Association for the Advancement of Science (AAAS) R&D Budget and Policy Program. Total R&D spending for fiscal year 2012 was set at $142 billion, down about $1.9 billion from 2011.

 

Comparing Innovation Transfer Activities of U.S. Research Universities 

A university's ability to create and share innovative technology and know-how should be evaluated in a holistic way that includes both academic and commercial activities. Here, the Innovation Excellence blog compares the innovation transfer activities of U.S. research universities in a new, multi-faceted way: by counting and mapping universities according to their ability to publish papers, generate new inventions, and attract industry research funding. 
Parting Quote

"There seems to be one quality of mind which seems to be of special and extreme advantage in leading him to make discoveries. It was the power of never letting exceptions go unnoticed."

 

English botanist Francis Darwin, speaking of his father, naturalist Charles Darwin.


University of Colorado's Office of Technology Transfer Mission Statement

The mission of the CU Technology Transfer Office is to aggressively pursue, protect, package, and license to business the intellectual property generated from the research enterprise, and to serve faculty, staff, and students seeking to create such intellectual property.

(303) 735-3711
ttocontact@cu.edu
http://www.cu.edu/techtransfer