The preliminary results of an important study out of Yale University were recently reported. The depth and distribution of facial and neck wrinkles of 114 early post-menopausal women were studied and graded according to a standard scale. Firmness of the forehead and cheek skin was also measured (by durometer). The results were then compared to measurements of bone marrow density (BMD) as performed by standard x- ray absorptiometry. The data clearly showed that severity of facial wrinkles are a strong indicator of a lower bone density!  On the other hand, firmer, less wrinkled facial skin is associated with a better BMD!  Collagen is one of the most important and supportive building block substances throughout the body.  Collagen is instrumental in the look and feel of the skin as well as the strength of the bones. Researchers will have to continue to explore what is happening (to the collagen?) that results in this negative effect on both appearance and BMD.  And what if the trend could be reversed; i.e., would therapies directed to improving one's overall collagen state result in both a better appearance and better bone strengthening as well?