Biosensis New Tracing Reagents

Dear Doctor   

Biosensis is pleased to announce the availability of our new 'Ready to Dilute' Staining Kits: Fluoro-Jade C for identifying degenerating neurons and Black-Gold II for identifying myelin. Each kit is available in easy to use,  ready-to-dilute liquid formats eliminating the tedious and messy preparation steps necessary with competitor offerings.  

Fluoro-Jade® C Staining Kits

Fluoro-Jade C, a novel marker for degenerating neurons
TR-100-FJ-R1


The causes and effects of neuronal degeneration are of major interest to a wide variety of neuroscientists. Paralleling this growing interest is an increasing number of methods applicable to the detection of neuronal degeneration. Fluoro-Jade C, like its predecessors, Fluoro-Jade and Fluoro-Jade B, has been found to stain all degenerating neurons, regardless of specific insult or mechanism of cell death. Fluoro-Jade C exhibits the greatest signal to background ratio, as well as the highest resolution. This translates to a stain of maximal contrast and affinity for degenerating neurons. This makes it ideal for localizing not only degenerating nerve cell bodies but also distal dendrites, axons and terminals. The dye is highly resistant to fading and is compatible with virtually all histological processing and staining protocols.

The Biosensis Fluoro-Jade® C RTD™ "Ready to Dilute" Staining Kit (TR-100-FJ) provides an easy to use assortment of Fluoro-Jade C, DAPI (for blue fluorescent Nissl counter stain), sodium hydroxide and potassium permanganate, all in liquid formats and all ready-to-dilute.

TR-100-FJ-R2After following the detailed protocol the Fluoro-Jade C labeled degenerating neurons are visualized with blue light excitation, while DAPI counter stained cell nuclei are visualized with ultra-violet illumination.  The Fluoro-Jade C Staining kit can be used on all kinds of preserved tissues, including fresh-frozen, paraformaldehyde or formalin fixed, and formalin fixed, paraffin embedded tissues.
***Biosensis also offers a trial kit at a much reduced price. (TR-100-FJT)  

Black-Gold® II Myelin Staining Kits

For staining normal and pathological myelin or for staining myelin and amyloid plaques

 

TR-100-BG-MS1  TR-100-BG-MS2 TR-200-BG-MS1 TR-200-BG-MS2  

Black-Gold II is a novel haloaurophosphate complex which localizes myelin within the central nervous system.  The use of Black-Gold II is tailored to studies using formalin or paraformaldehyde fixed, non-paraffin embedded, non-solvent processed tissue.  The Black-Gold II myelin staining kits stain large myelinated tracts dark red-brown, while the individual myelinated axons appear black.  This novel tracer can be used to localize both normal and pathological myelin.  Black-Gold II can demonstrate and characterize specific myelin changes associated with exposure to diverse neurotoxicants including kainic acid, domoic acid, 3-nitropropionic acid, Fluoro-Gold and isoniazid.  Black-Gold II can also be combined with other histochemical markers including Nissl stains, retrogradely transported fluorescent tracers and fluorescent markers of neuronal degeneration.  The advantages associated with the Black-Gold II include high resolution, high contrast, short histochemical processing time, versatility, and consistent reproducibility.

 

Biosensis is pleased to announce the availability of two new Black-Gold II RTD™ "Ready to Dilute" myelin staining kits.  

 

The Biosensis Black-Gold® II RTD™ - Toluidine Blue O kit (TR-100-BG) allows you to localize myelin, both individual fibers and tracts, along with the option of co-localizing cell bodies via the Toluidine Blue. Black-Gold II labeled myelinated fibers appear nearly black, while Toluidine Blue O labeled cellular Nissl bodies are blue under bright field illumination.     

***Biosensis also offers a trial kit at a much reduced price. (TR-100-BGT) 

 

The Biosensis Black-Gold® II RTD™ - Congo Red kit (TR-200-BG) allows you to localize myelin, both individual fibers and tracts, along with the option of co-localizing amyloid plaques with the Congo Red, which appear bright red under bright field illumination.

***Biosensis also offers a trial kit at a much reduced price. (TR-200-BGT)      

   

Fluoro-Jade® is a registered trademark of Histo-Chem, Inc.  

Black-Gold® is a registered trademark of Histo-Chem, Inc.

Photos courtesy of Dr Larry Schmued.   


 When you want the best reagents, trust Biosensis 

 

The staff at Biosensis has many years of combined experience in manufacturing and working with antibodies and has published over 340 peer reviewed research publications in the field of neuroscience. We guarantee to provide you with the antibody information you need to get your research published.
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If you have a query on any of our products, please contact us at biospeak@biosensis.com.
 
Sincerely,
Tina

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