Why buy Biosensis MLR2 antibodies?
Our mouse
monoclonal antibody to p75NTR Clone MLR2 is unique. Developed
in p75NTR knock-out mice, it is the only monoclonal antibody available
that recognizes the mouse form of the receptor. MLR2 has been used
extensively in studies with tissues and cells from human, rat, mouse,
rabbit and guinea-pig.
MLR2
has been used to detect native p75NTR by Western blot,
FACS and immunohistochemistry. This unique antibody has also been used in retrograde
transport studies and for the study of intracellular trafficking. Biosensis MLR2 antibodies conjugated to Atto 488 or FITC
are suitable for immunofluorescence, flow cytometry and real-time
Confocal microscopy including FRET.

Immunofluoresence staining of MLR2 uptake into mesenteric nerves following in vivo administration in adult rat.
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What if you need an antibody for rat p75NTR that has been used in hundreds of papers?
Mouse monoclonal antibody to p75NTR Clone MC192 has been used in research for more than 20 years. It was developed using rat PC12 cells that express p75 on their surface. MC192 recognizes the extracellular domain of the neurotrophin receptor
p75NTR in rat only.
MC192 antibody may be used for immunocytochemical
localisation of rat cells expressing p75NTR, ELISA and western blot.
This antibody has also been used for the construction of the
MC192-saporin immunotoxin for specific elimination of neuronal
populations in basal forebrain cholinergic neurons to generate an
animal model for Alzheimer's disease. Using Flow Cytometry, this
antibody has frequently been employed for panning to isolate
p75NTR-expressing rat cells such as embryonic motor neurons.
Immunofluorescence staining using mouse monoclonal antibody to rat p75NTR [MC192] and fluorescent-labelled secondary antibody in 4% formaldehyde-fixed cryostat brain sections from basal forebrain.
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