Our mouse monoclonal antibody to p75NTR Clone MLR2 is unique.  Developed in p75NTR knock-out mice, it is the only monoclonal antibody available that recognizes the mouse form of the receptor. MLR2 has been used extensively in studies with tissues and cells from human, rat, mouse, rabbit and guinea-pig.

MLR2 has been used to detect native p75NTR by Western blot, FACS and immunohistochemistry. This unique antibody has also been used in retrograde transport studies and for the study of intracellular trafficking. Biosensis MLR2 antibodies conjugated to Atto 488 or FITC are suitable for  immunofluorescence, flow cytometry and real-time Confocal microscopy including FRET.

Mouse monoclonal antibody to p75NTR Clone MC192 has been used in research for more than 20 years.  It was developed using rat PC12 cells that express p75 on their surface. MC192 recognizes the extracellular domain of the neurotrophin receptor p75NTR in rat only.

MC192 antibody may be used for immunocytochemical localisation of rat cells expressing p75NTR, ELISA and western blot. This antibody has also been used for the construction of the MC192-saporin immunotoxin for specific elimination of neuronal populations in basal forebrain cholinergic neurons to generate an animal model for Alzheimer's disease. Using Flow Cytometry, this antibody has frequently been employed for panning to isolate p75NTR-expressing rat cells such as embryonic motor neurons.