e-marketing p75NTR #2
Dear Doctor

Do you need to target p75NTR?

Biosensis has a range of proven and well characterized antibodies for p75NTR detection including custom fluorescent conjugates to meet your specific needs:
  • anti-human and anti-mouse MLR2 antibodies (featured below)
  • anti-rat MC192 antibodies (featured below)
  • anti-human ME20.4 antibodies
Recently, our MLR2 antibody was used by Weise et al (2010) in Nature Protocols for the isolation and in vitro cultivation of embryonic primary motoneurons from individual mouse embryos using a novel p75NTR antibody-based panning technique.

Our anti-rat MC192 antibody has been used by many researchers over many years. Most recently Davies et al (2010) used MC192 to detect p75NTR in rat dorsal root ganglia.
Why buy Biosensis MLR2 antibodies?

Our mouse monoclonal antibody to p75NTR Clone MLR2 is unique.  Developed in p75NTR knock-out mice, it is the only monoclonal antibody available that recognizes the mouse form of the receptor. MLR2 has been used extensively in studies with tissues and cells from human, rat, mouse, rabbit and guinea-pig.

MLR2 has been used to detect native p75NTR by Western blot, FACS and immunohistochemistry. This unique antibody has also been used in retrograde transport studies and for the study of intracellular trafficking. Biosensis MLR2 antibodies conjugated to Atto 488 or FITC are suitable for  immunofluorescence, flow cytometry and real-time Confocal microscopy including FRET.

MLR-2 Mesentery


Immunofluoresence staining of MLR2 uptake into mesenteric nerves following in vivo administration in adult rat.


What if you need an antibody for rat p75NTR that has been used in hundreds of papers?

Mouse monoclonal antibody to p75NTR Clone MC192 has been used in research for more than 20 years.  It was developed using rat PC12 cells that express p75 on their surface. MC192 recognizes the extracellular domain of the neurotrophin receptor p75NTR in rat only.

MC192 antibody may be used for immunocytochemical localisation of rat cells expressing p75NTR, ELISA and western blot. This antibody has also been used for the construction of the MC192-saporin immunotoxin for specific elimination of neuronal populations in basal forebrain cholinergic neurons to generate an animal model for Alzheimer's disease. Using Flow Cytometry, this antibody has frequently been employed for panning to isolate p75NTR-expressing rat cells such as embryonic motor neurons.

Biospeak: Alzheimer's titleImmunofluorescence staining using mouse monoclonal antibody to rat p75NTR [MC192] and fluorescent-labelled secondary antibody in 4% formaldehyde-fixed cryostat brain sections from basal forebrain.


More tools for neurotrophin research

Mouse monoclonal to human p75NTR Clone ME20.4
NGF Elisa Kit
  1. Human
  2. Mouse
  3. Rat
NT3 Elisa Kit
  1. Human
  2. Mouse
  3. Rat
BDNF Elisa Kit
  1. Human
  2. Mouse
  3. Rat
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BioSpeak

Each month, our Biospeak e-bulletins (link to newsletters) highlight recent progress in important research areas such as:
  1. Avoiding manuscript rejection
  2. ELISA Kits
  3. Stem Cells
  4. Neurotrophins
  5. Semaphorins
  6. TRK Receptors
  7. p75NTR
Closing Headline
Web site guarantee logoShould your manuscript ever be rejected by ANY journal because of insufficient information about a Biosensis antibody, we will gladly refund TWICE the purchase price of that antibody!

By researchers for researchers!

Our staff have over 60 years experience in the manufacture and use of antibodies, having published over 340 peer reviewed research publications. So, if you have a query on any of our antibodies, please contact us at biospeak@biosensis.com.
 
Sincerely,
Tina
Contact Information
Email: tina@avibiomail.com
Phone: + 61-43-166-5519
Web: www.biosensis.com