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Dear Doctor

Insulin-like Growth Factors (IGFs) are important mediators of growth and development and also play key roles in cellular transformation affecting the survival and growth of malignant cells. IGFs and their binding proteins (IGFBP) continue to attract attention as potential therapeutics.

This issue of BioSpeak highlights some recent progress in the area of IGF signaling, tumor growth and the potential of targeting the IGFs for drug development.
Hot topics in IGF research
Two recent reviews examining IGF-I as a potential drug target
Surprising findings of anti-proliferative actions of high levels of endogenous IGFBP-3
IGF bioactivity is mediated more effectively by the IGF-I receptor than by the Insulin or hybrid receptors
Quality IGF ELISA Kits available from Biosensis
Two recent reviews examining IGF-I as a potential drug target
Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?
T.J. Smith Pharmacol Rev. 2010 Jun;62(2):199-236 Abstract

Targeting the IGF1 axis in cancer proliferation.
I. Bruchim, Z. Attias, H. Werner Expert Opin Ther Targets. 2009 Oct;13(10):1179-92 Abstract
Surprising findings of anti-proliferative actions of high levels of endogenous IGFBP-3
Effects of endogenous insulin-like growth factor binding protein-3 on cell cycle regulation in breast cancer cells.
M.K. O'Han, R.C. Baxter RC, L.J. Schedlich Growth Factors. 2009 Dec;27(6):394-408 Abstract
IGF bioactivity is mediated more effectively by the IGF-I receptor than by the Insulin or hybrid receptors
Silencing of the insulin receptor isoform A favors formation of type 1 insulin-like growth factor receptor (IGF-IR) homodimers and enhances ligand-induced IGF-IR activation and viability of human colon carcinoma cells.
G.V. Brierley et al Endocrinology. 2010 Apr;151(4):1418-27 Abstract
Quality IGF ELISA Kits available from Biosensis

Biosensis quality ELISA kits make quantification of Insulin-like Growth Factors and their Binding Proteins easy. 
  • High level of sensitivity
  • 192-well strip format, use only what you need
  • Easy to use with a detailed protocol in the kit
  • Technical support available
IGF-I ELISA kitBEK-2028 Curve
IGF-binding protein 1 ELISA Kit
 Human IGF-II ELISA kit (BEK-2029-2P)

Human IGF-binding protein 3 ELISA Kit (BEK-2032-2P)

Biosensis has over 150 kits available. To view the full range of kits, visit our web site at www.biosensis.com.
The Biosensis UNCONDITIONAL Guarantee
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Should your manuscript ever be rejected by ANY journal because of insufficient information about a Biosensis antibody, we will gladly refund TWICE the purchase price of that antibody!

By researchers for researchers!

Our staff have over 60 years experience in manufacturing and using antibodies and over 340 peer reviewed research publications.  If you have any questions, one of our experienced researchers is always there to help at biospeak@biosensis.com.

Until next time, good luck with your research.

Sincerely,
 
Tina


P.S. Have you missed previous issues of BioSpeak? Click Here