Biospeak capsaicin receptors

Dear Doctor

Members of the family of transient receptor potential (TRP) channel proteins function as noxious stimuli detectors. As a result they have become targets for potential analgesics. Mutations in these channels lead to altered ion channel activity and are associated with hereditary neuropathies such as Charcot-Marie-Tooth disease type 2C (CMT2C) also known as Scapuloperoneal spinal muscular atrophy (SPSMA).

This issue of BioSpeak highlights some recent progress in the area of TRP channels.

Hot topics in TRP channel research
TRPV4 mutations identified in channelopathies
Developing novel drugs by targeting TRP channels
Snakes see infrared through TRP channels
Quality sensory antibodies available from Biosensis
TRPV4 mutations identified in channelopathies
Alterations of TRPV4 are known to underlie a family of autosomal dominant skeletal dysplasias. Now, three new studies identify TRPV4 mutations responsible for Spinal Muscular Atrophy (also known as Charcot-Marie-Tooth disease Type 2C). Mutations lead to altered ion channel activity.

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4
Han-Xiang Deng et al. Nat Genet. 2010 Feb;42(2):165-9 Abstract

Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C
Michaela Auer-Grumbach et al. Nat Genet. 2010 Feb;42(2):160-4 Abstract

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C
Guida Landouré et al. Nat Genet. 2010 Feb;42(2):170-4 Abstract

Critiques of these recent findings have been published:

Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies
Magdelena Zimon et al. Brain. 2010 133:1798-1809 Abstract

Channelopathies converge on TRPV4
Nilius B. and Owsianik G. Nat Genet. 2010 Feb;42(2):98-100 Abstract
Developing novel drugs by targeting TRP channels
Now that the role of TRP channels is becoming clearer both physiologically and pathologically, it is possible to contemplate targeting these channel proteins for drug development. Some recent reviews discuss the possibilities.

Challenges faced in choosing novel targets to treat chronic pain

DA Henze, Future Med Chem 2009 1:231-235

Analgesic targets: today and tomorrow
Ian W Rodger Inflammopharmacology 2009 Jun;17(3):151-61 Abstract

Transient receptor potential channels: targeting pain at the source

Patapoutian A, Tate S and Woolf CJ. Nat Rev Drug Discov. 2009 Jan;8(1):55-68 Abstract
And now for something different.. snakes see infrared through TRP channels
Snakes use a unique sensory system for detecting infrared radiation enabling the generation of a thermal image. This study identifies TRPA1 channels as the infrared receptors on sensory nerve fibres that innervate the pit organ that snakes use to identify prey or predators.

Molecular basis of infrared detection by snakes.

Gracheva EO et al. Nature. 2010 Apr 15;464(7291):1006-11 PMID: 20228791 Abstract
Quality sensory antibodies available from Biosensis

VRL IHC immageRabbit antibody to VRL-1 (744-761): Affinity purified
Immunohistochemical staining of Vanilloid Receptor Like Protein (VRL-1) in rat dorsal horn using rabbit polyclonal antibody to rat VRL-1 (R-078-50).







Mouse mo
Biospeak capsaicin receptorsnoclonal antibody to rat capsaicin Receptor (819-838)
I
mmunohistoch
emical detection of capsaicin receptor in rat dorsal root ganglia staining a subpopulation of sensory neurons using rat Capsaicin receptor antibody (M-008-100).

This month we have doubled the volume of this antibody for the same price. Only $267 USD for 100ug!





R-076-100Rabbit antibody to human capsaicin receptor (608-621): Whole serum
Detection of capsaicin receptor in small neurons in rat dorsal root ganglion using human capsaicin receptor antibody (R-076-100). Rat spinal cord also shows a high specific stain with little background.


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Our staff have over 60 years experience in manufacturing and using antibodies and over 340 peer reviewed research publicationsIf you have any questions, one of our experienced researchers is always there to help at biospeak@biosensis.com.

Until next time, good luck with your research.


Sincerely,
 
Tina


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