BioSpeak: Focus on Autophagy title

Dear Doctor ,

Autophagy (Greek: Self digestion) is an intracellular process involved in the removal of damaged or misfolded proteins or organelles.

Autophagy pathway dysfunction has been implicated in  human diseases such as cancer, heart disease, infection, liver disease and several neurodegenerative disorders.

In this issue biosensis presents recent progress in the rapidly growing area of autophagy research.
Hot topics in Autophagy research
Demonstration of NOD2-mediated autophagy requirement for both bacterial handling and generation of MHC Class II antigen-specific CD4(+) T cell responses in dendritic cells and its relevance for Crohn's disease
Identification of alternate autophagy pathways learned from analysis of embryologic development
A novel approach to the biochemical isolation of autophagosomal membranes using affinity purification allows identification of the dynamics of autophagosomal compartments
The role of autophagy in the pathogenesis of Parkinson's disease
Demonstration of NOD2-mediated autophagy requirement for both bacterial handling and generation of MHC Class II antigen-specific CD4(+) T cell responses in dendritic cells and its relevance for Crohn's disease

1. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. 

Cooney R, Baker J, Brain O, Danis B, Pichulik T, Allan P, Ferguson DJ, Campbell BJ, Jewell D, Simmons A. Nature Medicine. 2010 Jan;16(1):90-7. Abstract

Comment in:
        Netea MG and Joosten LA Nature Medicine. 2010 Jan;16(1):28-30  Article
Identification of alternate autophagy pathways learned from analysis of embryologic development

2. Sculpturing digit shape by cell death

Montero JA and Hurle JM Apoptosis. 2009 Dec 30 Abstract

3. Discovery of Atg5/Atg7-independent alternative macroautophagy

Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S. Nature. Oct 2009 Abstract
A novel approach to the biochemical isolation of autophagosomal membranes using affinity purification allows identification of the dynamics of autophagosomal compartments

4. Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartments

Gao W, Kang JH, Liao Y, Ding WX, Gambotto AA, Watkins SC, Liu YJ, Stolz DB, Yin XM. J Biol Chem. 2010 Jan 8;285(2):1371-83 Abstract
The role of Autophagy in the pathogenesis of Parkinson's disease

5. The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

Michiorri S, Gelmetti V, Giarda E, Lombardi F, Romano F, Marongiu R, Nerini-Molteni S, Sale P, Vago R, Arena G, Torosantucci L, Cassina L, Russo MA, Dallapiccola B, Valente EM, Casari G.

Cell Death Differ. 2010 Jan 8 Abstract

6. Pathogenesis of Parkinson's disease: emerging role of molecular chaperones

Bandopadhyay R, de Belleroche J. Trends Mol Med. 2009 Dec 23 Abstract
Some quality Autophagy antibodies available from biosensis

Rabbit antibody to ATG16 L1: whole serum R-158-100
Rabbit antibody to APG5: IgG R-138-500
Rabbit antibody to MAP1LC3 A (MAP1LC3 A, APG8 a): whole serum R-146-100


So if you have an autophagy reagent related question, email one of our experienced researchers at biospeak@biosensis.com.

Support for researchers from researchers! Our staff have over 60 years experience in manufacturing and using antibodies and have published over 340 peer reviewed research publications.

"Good luck with your research"

Sincerely,
 
Tina