Semaphorin Marketing Title


Greetings!

 The discovery and characterization of semaphorins over the last 15 years has opened an extraordinarily wide field of investigation. Although initially described as a large group of proteins with multiple potencies controlling cell migration and axonal growth cone guidance in the nervous system, they are now known to act as crucial modulators during development of the whole body, and also have been implicated in the establishment of highly structured and complex organs and networks. Semaphorins produce bi-functional signals capable of growth promotion or growth inhibition. Abnormal semaphorin expression or regulation is associated with numerous diseases ranging from nerve lesion and neurodegenerative diseases, autoimmune diseases to cancer.

This issue of BioSpeak highlights the some of the most recent progress in the area of Semaphorin research.
Hot topics in Semaphorin research
Identification of the role of semaphorin/plexin as a critical determinant of synaptic specificity and neural topography
Chemoattraction and repulsion actions of the Semaphorins in the nervous system
International group finds Semaphorin 5A is a key genetic player in autism
Some quality Semaphorin/Plexin antibodies available from biosensis
Identification of the role of semaphorin/plexin as a critical determinant of synaptic specificity and neural topography

1. Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition
Pecho-Vrieseling E, Sigrist M, Yoshida Y, Jessell TM, Arber S. Nature. 2009 Jun 11;459 (7248):842-6 Abstract

2. Pre-target axon sorting establishes the neural map topography
Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H. Science. 2009 Jul 31;325(5940):544-5 Abstract
Chemoattraction and repulsion actions of the Semaphorins in the nervous system

3. Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ. J Neurosci. 2009 Oct 7;29(40):12542-57. Abstract

4. FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F. Yamauchi K, Mizushima S, Tamada A, Yamamoto N, Takashima S, Murakami F. J Neurosci. 2009 Apr 1;29(13):4044-55. Abstract
International group finds Semaphorin 5A is a key genetic player in autism

5. A genome-wide linkage and association scan reveals novel loci for autism.
Weiss LA, Arking DE, Daly MJ, Chakravarti A et al. Nature. 2009 Oct 8;461(7265):802-8.  Abstract
Some quality Semaphorin/Plexin antibodies available from biosensis

 M-886-100 (Sema-3A); M-889-100 (Sema-4B); M-875-100 (Sema-7A); M-888-100 (Sema-4D)



So if you have a Semaphorin reagent related question, email one of our experienced researchers at biospeak@biosensis.com.

Support for researchers from researchers! Our staff have over 60 years experience in manufacturing and using antibodies and have published over 340 peer reviewed research publications.

"Good luck with your research"

Sincerely,
 
Tina!


P.S. Have you missed previous issues of BioSpeak? Click Here