New genes associated with Alzheimer's disease
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1.
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O; the European Alzheimer's Disease Initiative Investigators, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P. Nat Genet. 2009 Sep 6. [Epub ahead of print] Abstract
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Progress towards therapeutic targets.
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2.
beta-Amyloid as a molecular therapeutic target in Alzheimer's disease.
Adlard PA, James SA, Bush AI, Masters CL.Drugs Today (Barc). 2009 Apr;45(4):293-304.
Abstract
3.
The role of apolipoprotein E in Alzheimer's disease.
Kim J, Basak JM, Holtzman DM. Neuron. 2009 Aug 13; 63(3):287-303.
Abstract
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Neurotrophins and Alzheimer's disease
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4.
The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.
Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L,
Ishikawa C, Massa SM, Wyss-Coray T, Longo FM. J Neurosci. 2009 Aug 26;29(34):10627-37.
Abstract
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Evidence for toxicity / protective profile of Beta-amyloid oligomers/ monomers
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5.
Beta-amyloid monomers are neuroprotective.
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A. J Neurosci. 2009 Aug
26;29(34):10582-7. Abstract
6. Structure-neurotoxicity relationships of amyloid {beta}-protein oligomers.
Ono K, Condron MM, Teplow DB. Proc Natl Acad Sci U S A. 2009 Aug 12. [Epub ahead of print]
Abstract
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So if you have an Alzheimer's disease reagent related question, email one of our experienced researchers at biospeak@biosensis.com.
Help for researchers from researchers! Our staff have over 60 years experience in manufacturing and using
antibodies and have published over 340 peer reviewed research
publications.
"Good luck with your research"
Sincerely,
Tina!
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