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Greetings!
Extensive research spanning half a century has
established a preeminent role for the neurotrophins
in promoting and regulating neuron survival, axon growth,
terminal arborization in neuronal development, modulation of synaptic plasticity, as well as neuroprotection in the adult nervous system. Their role in human diseases such as cancer and several psychiatric and neurodegenerative disorders has established them as potential targets for future therapeutic applications.
In this issue biosensis highlights recent progress in the continually fascinating and growing area of neurotrophin research.
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| Advances in understanding the role of BDNF and/ or NGF in cognition and Alzheimer's disease.
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1. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.
Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, Laferla FM. Proc Natl Acad Sci U S A. 2009 Jul 24. Abstract
2. beta-Amyloid impairs axonal BDNF retrograde trafficking.
Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW. Neurobiol Aging. 2009 Jun 18. Abstract
3. Development of a non invasive NGF-based therapy for Alzheimer's disease.
Covaceuszach S, Capsoni S, Ugolini G, Spirito F, Vignone D, Cattaneo A. Curr
Alzheimer Res. 2009 Apr 6 (2):158-70. Abstract
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| New activities for the ProNeurotrophins, ProNGF and ProBDNF.
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4. Biological activity of Nerve Growth Factor precursor is dependent upon relative levels of Its receptors. Masoudi R, Ioannou MS, Coughlin MD, Pagadala P, Neet KE, Clewes O, Allen SJ,
Dawbarn D, Fahnestock M. J Biol Chem. 2009 Jul 3;284(27):18424-33. Abstract
5. Neuronal release of proBDNF.
Yang J, Siao CJ, Nagappan G, Marinic T, Jing D, McGrath K, Chen ZY, Mark W, Tessarollo L, Lee FS, Lu B, Hempstead BL. Nat Neurosci. 2009 Feb;12(2):113-5. Abstract
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Receptor regulation of ProNeurotrophin signalling.
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6. NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death. Kim T, Hempstead BL. EMBO J. 2009 Jun 3; 28(11):1612-23. Abstract
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So if you have an neurotrophin-related question, email one of our experienced researchers at biospeak@biosensis.com.
Help for researchers from researchers! Our staff have over 60 years experience in manufacturing and using
antibodies and have published over 340 peer reviewed research
publications.
"Good luck with your research"
Sincerely,
Tina!
Have you missed previous issues of BioSpeak? Click Here
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Win a $100 iTunes Voucher!
 Image subject to copyright by Apple®
Biosensis Image Competition - can we get on your nerves?
Calling
all scientists using quality antibodies from Biosensis to submit your
photo, image or micrograph to win a $100 iTunes voucher.
To enter: email your image(s) in 300dpi format (jpeg or tiff file format) to imagecomp@biosensis.com with;
- Your full name and title
- Institute/company/university that supports your research (if applicable).
- Biosensis catalogue number(s) of the product(s) used for your contribution.
- Description of the type of experiment (i.e. IHC, WB, etc...)
- General area of research you are undertaking.
Biosensis is unable
to upload all entries and contributions. The winning image(s) will be
displayed on the Biosensis website (www.biosensis,com) on 31 August
2009. The winner will be notified via email. The winner will receive
a $100 iTunes voucher. Terms and conditions.
Offer Expires: 30th August 2009
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