BioSpeak: Focus on Autophagy title


Greetings!

Autophagy (Greek: Self digestion) is an intracellular process involved in the removal of damaged or misfolded proteins or organelles.

Autophagy pathway dysfunction has been implicated in  human diseases such as cancer, heart disease, infection, liver disease and several neurodegenerative disorders.

In this issue biosensis presents recent progress in the rapidly growing area of autophagy research.

Hot topics in Autophagy research
Neurons handle autophagy differently to other cell types.
A surprising role for autophagy in metabolizing lipid.
Autophagy in tumorigenesis and metabolic regulation.
The search for a functional reporter in autophagy!
Neurons handle autophagy differently to other cell types.

1. Protein turnover differences between neurons and other cells. Tsvetkov AS, Mitra S, Finkbeiner S. Autophagy. 2009 Jul 9;5(5). Abstract


2. Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. Tydlacka S, Wang CE, Wang X, Li S, Li XJ. J Neurosci. 2008 Dec 3;28(49):13285-95. Abstract

A surprising role for autophagy in metabolizing lipid.

3. Autophagy regulates lipid metabolism. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ. Nature. 2009 Apr 30;458(7242):1131-5. Abstract

    Comment in:
        Nature. 2009 Apr 30;458(7242):1118-9.
Abstract

Autophagy in tumorigenesis and metabolic regulation.

4. Autophagy suppresses tumorigenesis through elimination of p62. Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, Dipaola RS, Karantza-Wadsworth V, White E. Cell. 2009 Jun 12;137(6):1062-75.
Abstract

The search for a functional reporter in autophagy!

5.
In search of an "autophagomometer". Rubinsztein DC, Cuervo AM, Ravikumar B, Sarkar S, Korolchuk V, Kaushik S. and Klionsky DJ. Autophagy. 2009 5:5, 1-5; July 1 Abstract



So if you have an autophagy related question, email one of our experienced researchers at [email protected].


Help for researchers from researchers! Our staff have over 60 years experience in manufacturing and using antibodies and have published over 340 peer reviewed research publications.

"Good luck with your research"

Sincerely,
 
Tina!

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Biosensis Image Competition - can we get on your nerves?
Calling all scientists using quality antibodies from Biosensis to submit your photo, image or micrograph to win a $100 iTunes voucher.

To enter: email your image(s) in 300dpi format (jpeg or tiff file format) to [email protected] with;
-    Your full name and title
-    Institute/company/university that supports your research (if applicable).
-    Biosensis catalogue number(s) of the product(s) used for your contribution.
-    Description of the type of experiment (i.e. IHC, WB, etc...)
-    General area of research you are undertaking.

Biosensis is unable to upload all entries and contributions. The winning image(s) will be displayed on the Biosensis website (www.biosensis,com) on 31 August 2009. The winner will be notified via email. The winner will receive a $100 iTunes voucher.  Terms and conditions.


Offer Expires: 30th August 2009