p75 Publication title


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Hot topics in p75NTR research
Understanding the mechanism of p75NTR receptor activation.
p75NTR and an interacting transcription factor promoting neuronal development.
Two new important studies describing the function of ProNGF with P75NTR and associated receptors...
....including one that may have therapeutic potential.
Characterization of the p75NTR-positive neural progenitor cells in adult brain.
Understanding the mechanism of p75NTR receptor activation.

1. Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers by Vilar M, Charalampopoulos I, Kenchappa RS, Simi A, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman WJ, Schiavo G, Bastiaens PI, Verveer PJ, Carter BD, Ib��ez CF. Neuron, 2009, Apr 16: 62(1):3-5 Abstract

See also the Editorial by Barker PA.

p75NTR and an interacting transcription factor promoting neuronal development.

2. The Sall2 transcription factor is a novel p75NTR binding protein that
promotes the development and function of neurons by Pincheira R, Donner DB.
Ann N Y Acad Sci. 2008 Nov; 1144:53-5. Abstract

Two new important studies describing the function of ProNGF with P75NTR and associated receptors...

3.
Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin by Clewes O, Fahey MS, Tyler SJ, Watson JJ, Seok H, Catania C, Cho K, Dawbarn D, Allen SJ.
J Neurochem. 2008 Nov;107(4):1124-35. Abstract

....including one that may have therapeutic potential!

4. The proNGF-p75NTR-sortilin signalling complex as new target for the therapeutic
treatment of Parkinson's disease by Chen LW, Yung KK, Chan YS, Shum DK, Bolam JP.
CNS Neurol Disord Drug Targets. 2008 Dec;7(6):512-23. Abstract
Characterization of the p75NTR-positive neural progenitor cells in adult brain.

5. Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling by Snapyan M, Lemasson M, Brill MS, Blais M, Massouh M, Ninkovic J, Gravel C, Berthod F, G�tz M, Barker PA, Parent A, Saghatelyan A.
J Neurosci. 2009 Apr 1; 29(13):4172-88. Abstract



Do you need to target p75 receptors in mouse, human or rat tissue?
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Sincerely,
 
Tina!

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