5 Key Publications In MND/ALS from Biosensis!
May 2009
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IN THIS ISSUE
New genes linked to MND/ALS
Importance of glia in ALS
Prefrontal dementias linked to MND
Important MND/ALS review
New genes linked to MND/ALS

1. Kwiatkowski TJ, Bosco DA, LeClerc AL et al (2009) Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis. Science 323: 1205 - 1208 Abstract

Importance of glia in ALS

2.  Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland DW (2008) Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 11:251-253  Abstract

3. Cassina P, Cassina A, Pehar M, Castellanos R, Gandelman M, de Leon A, Robinson KM, Mason RP, Beckman JS, Barbeito L, Radi R (2008) Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci 28:4115-4122  Abstract


Prefrontal dementias linked to MND

4. Foulds P, McAuley E, Gibbons L et al (2008) TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration. Acta Neuropathol 116: 141-146.  Abstract


Important MND/ALS review

5. Polymenidou M, Cleveland DW (2008) Motor neuron disease: The curious ways of ALS. Nature 454:284-2854.  Abstract
 
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