Trk Title Final
 Greetings!

Trk's are a family of membrane-bound receptors that undergo phosphorylation following binding to neurotrophin ligands. During development Trk signaling leads to neurogenesis, differentiation and survival of many neuronal subpopulations. In adults, Trk's have a central role in a range of physiological processes both within the nervous system, and more extensively in  the immune and endocrine systems. In disease, particularly Azheimers, Amyotrophic Lateral Sclerosis and brain tumors, Trk's have proved important as diagnostics and potential therapeutic targets. Biosensis offers an extensive range of monoclonal and polyclonal antibodies that have been well characterized in published studies for use in western blotting, immunohistochemistry, receptor trafficking and biological function assays.
 
TrkA R152-100 TrkA antibodies
Immunohistochemical staining of Tyrosine Kinase Receptor A (TrkA) in the dorsal horn of adult rat spinal cord using rabbit antibody (R-152-100) at a dilution of 1:2000, followed by anti rabbit HRP secondary antibody staining. (Courtesy of Xin Fu Zhou, Flinders University).

      TrkA monoclonal (enquire here)

      TrkA polyclonal (click here)
 
Trk B R-149-100_tri_g_150 TrkB antibodies
Immunohistochemical staining of Tyrosine Kinase Receptor B (TrkB) in adult rat trigeminal nerve using rabbit antibody (R-149-100) at a dilution of 1: 3000, followed by secondary detection with anti-rabbit HRP.

      TrkB polyclonal (click here)

      TrkB (23-36) polyclonal (click here)
Trk C_151-100_tri-g_150 TrkC antibodies
Immunohistochemical staining of Tyrosine Kinase Receptor C (TrkC) in adult rat trigeminal nerves using rabbit antibody (R-151-100) at a dilution of 1:3000 and counter stained with anti-rabbit HRP.

      TrkC Monoclonal (enquire here)

      TrkC Polyclonal (click here)
 
Available Feb '09!
Trk_C_monoclonal
2B7: a monoclonal antibody to TrkC and  5C3: a monoclonal antibody to TrkA. Produced by researchers at McGill University, these antibodies are structural and functional mimics of nerve growth factor (NGF) and neurotrophin-3 (NT-3) respectively, and act as artificial receptor agonists!

Ref:
Esteban PF, et al., (2006) J. Cell Biol. 173: 291-299


LeSauteur L, et al.,(1996) J Neuroscience 16: 1308-1316 
Quick Links

TrkA (poly)
TrkB (poly)
TrkB 23-36 (poly)
TrkC (poly)



Please do not hesitate to contact us with any questions regarding our range of antibodies and custom conjugates.
 
Sincerely,
 
Tina


Contact Information
Email: marketing@avibiomail.com
Phone: + 61-43-166-5519
Web: www.biosensis.com