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Trk's are a family of membrane-bound receptors that undergo phosphorylation following binding to neurotrophin ligands. During development Trk signaling leads to neurogenesis, differentiation and survival of many neuronal subpopulations. In adults, Trk's have a central role in a range of physiological processes both within the nervous system, and more extensively in the immune and endocrine systems. In disease, particularly Azheimers, Amyotrophic Lateral Sclerosis and brain tumors, Trk's have proved important as diagnostics and potential therapeutic targets. Biosensis offers an extensive range of monoclonal and polyclonal antibodies that have been well characterized in published studies for use in western blotting, immunohistochemistry, receptor trafficking and biological function assays.
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