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VIDEO form PBS News Hour 8/22/2012: As Whooping Cough Rebounds in U.S., Infants at Greatest Risk |
Pertussis is a very serious disease with a high risk of damaging complications. The pertussis vaccine is very safe and effective. Dr. McAllister agrees with the expert recommendations that all children receive a DTaP vaccine at 2-months, 4-months, 6-months, 15-months and 4-years, and all adolescents should receive a Tdap vaccine at 11. In addition any older adolescent or adult who has not had a Tdap vaccine should also get one.
Whooping cough, another name for pertussis, is a very contagious disease caused by the bacteria
Bordetella pertussis. It can be serious for anyone, but life-threatening for newborns and infants.
Whooping cough in infants is very concerning because infants suffer the most serious complications. In infants younger than 1 year old who get whooping cough, more than half must be hospitalized. For infants who are hospitalized, 1 out of 5 develops pneumonia (lung infection), and, sadly, about 1 out of 100 dies.
Disease DescriptionWhooping cough begins like a common cold-runny nose, low-grade fever, and coughing. Unlike the common cold, which lasts 7-10 days, the pertussis cough continues past day 10 and may get worse. For adolescents and for older children, coughing can last up to 10 weeks or more. That's why this disease is called the 100-day cough.
Coughing can come in violent fits. The name "whooping cough" comes from the high-pitched noise-a "whoop"-that infants and children make when they gasp for air after a fit of coughing. Very young infants may not actually cough as the disease gets worse. Instead, they may have hard time breathing, or even stop breathing for short periods. Adolescents and adults usually do not whoop.
Neurologic complications such as seizures and
encephalopathy (a diffuse disorder of the brain) may occur as a result of hypoxia (reduction of oxygen supply) from coughing, or possibly from bacterial toxin. Neurologic complications of pertussis are more common among infants. Other less serious complications of pertussis include otitis media, anorexia, and dehydration. Complications resulting from pressure effects of severe paroxysms include pneumothorax, epistaxis, subdural hematomas, hernias, and rectal prolapse.
Effectiveness of VaccineBefore the availability of vaccine, pertussis was common among children. During the period from 1940 through 1945, more than 1 million cases of pertussis were reported, an average of 175,000 cases per year (incidence of approximately 150 cases per 100,000 population). Following introduction of whole-cell pertussis vaccine in the 1940s, pertussis incidence gradually declined with 15,000 reported cases in 1960 (approximately 8 per 100,000 population). By 1970, annual incidence was fewer than 5,000 cases per year, and during 1980-1990, an average of 2,900 cases per year were reported (approximately 1 per 100,000 population).
What's concerning is that pertussis incidence has been gradually increasing since the early 1980s. During 2001-2003, the highest average annual pertussis incidence was among infants younger than 1 year of age (55.2 cases per 100,000 population), and particularly among children younger than 6 months of age (98.2 per 100,000 population). In 2002, 24% of all reported cases were in this age group. However, in recent years, adolescents (11-18 years of age) and adults (19 years and older) have accounted for an increasing proportion of cases. In 2004 and 2005, approximately 60% of reported cases were among persons 11 years of age and older. Increased recognition and diagnosis of pertussis in older age groups probably contributed to this increase of reported cases among adolescents and adults.
There are two vaccines available to protect against pertussis, DTaP and Tdap. Both vaccines provide protection against three diseases (diphtheria, tetanus, and pertussis) there are no vaccines which protect only against pertussis. DTaP is approved for children under 7. Tdap, which has a reduced dose of the diphtheria and pertussis vaccines, is approved as a booster for adolescents starting at the age of 11 and adults ages 19 to 64.
Risk of vaccineAll immunizations have a risk of side effects, but most of them are mild and serious side effects are very rare.
The most common side effects are usually mild and occur in about 1 out of 4 children. They include the following:
- Redness, swelling, and pain from the shot
- Fever
- Vomiting
More serious side effects include:
- Nonstop crying for 3 hours or more occurs in about 1 out of 1,000 children
- Seizures (jerking or staring) occur in about 1 out of 14,000 children; the seizures do not cause long-term harm
- A fever over 105 degrees occurs in about 1 out of 16,000 children
Severe reactions have been reported but are very rare, less than 1 out of 1,000,000 children. These reactions are so rare it is impossible to tell if they are caused by the vaccine or just occurred coincidentally to the vaccine administration. These reactions include:
- Serious allergic reaction
- Long-term seizures
- Coma, or lowered consciousness
- Permanent brain damage