Greetings !
Welcome to the November edition
of our Discover More newsletter.
We have been pleased to see the positive response from the release of our version 7 of Chenomx NMR Suite. The single biggest improvement is automatic fitting of individual metabolite signatures to the experimental spectrum. This offers much faster fitting of all the peaks in the signature at once at the click of a mouse. Our software license now includes use of all the metabolite libraries that we have
available, including 400 through 700 MHz NMR spectrometers.
This year we have exhibited and sponsored conferences in Munich (Metabolomics-and-more), Amsterdam (Metabolomics society), University of Florida (Metabolomics workshop) and Melbourne (Australasian Metabolomics 2010). One of the key things we are seeing from these conferences is an
increase in valuable biological applications of metabolomics. Presentations at previous conferences tended to focus on methods development and validation. This is a good sign for our industry and shows a maturation of the technology and methods in our field.
Neil Taylor
President
|
 | Sales and Marketing Contact
|
Introducing... Margo Klimowicz.
Margo has taken on the role of account manager at Chenomx and would be pleased to answer any of your questions regarding our products and services.
Her contact information is listed below:
Margo Klimowicz
Account Management
Office: 1-780-432-0033 ext. 2228
Email:mklimowicz@chenomx.com
|
| Publications Using Chenomx NMR Suite |
In the September 2010 issue of Metabolomics, there was a study published by Dewer et al. entitled Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by 1H NMR spectroscopy. Resistance to the cancer therapy drug imatinib is a current problem in the treatment of chronic myelogenous leukemia (CML). In this study, 1H NMR spectroscopy was used to compare the metabolic phenotypes of a CML line and an imatinib-resistant CML line. The patented "Targeted Profiling" technology of NMR Suite was used to identify and quantify metabolites in cell extract samples, and the results showed major differences in the glycolytic profiles and total creatine pools of the two cultures. Furthermore, 31P NMR was used to confirm the high levels of phosphocreatine in the imatinib-resistant cells. This study demonstrates the utility of NMR spectroscopy for discerning metabolic profiles between different cell lines.To see the abstract and sign-in to read this paper click here.
If you have published any material using Chenomx NMR Suite, please do not hesitate to let us know so that we can mention it in this newsletter. We would love to see it!
For other publications, case studies, archived newsletters, news, and application notes using Chenomx NMR Suite click here.Anyone can benefit from this powerful technology by using Chenomx metabolite profiling services or software. |
| Chenomx NMR Suite 7.0 Tips |
 You can have Profiler suggest concentration and transform values for the currently selected compound by clicking Compound > Selected Compound > Fit Automatically, or by pressing the space bar. The maximum allowed concentration in Profiler for any compound is 5000 mM (5 M). When you select mg/dL as the concentration unit, the maximum value varies per compound, since the units incorporate the molecular weight of the compound. However, the maximum value is always equivalent to 5000 mM. More FAQs. |
| Did You Know? |
|
The fingerprints of koala bears are virtually indistinguishable from those of humans, so much so that they could be confused at a crime scene.
|
