"To raise new questions, new possibilities, to regard old problems from a new angle, requires creative imagination and marks real advance in science."

In the June 2009 issue of Molecular Vision, there was a study published by Young et al. entitled Metabolomic analysis of human vitreous humor differentiates ocular inflammatory disease.

In this study, NMR-based metabolomic analysis of human vitreous humor was used to assess the potential for specific biomarkers that define either disease type or response to treatment for ocular disease. Vitreous samples from patients with a range of vitreoretinal disorders were subjected to high-resolution 1Hnuclear magnetic resonance spectroscopy (NMR). Provisional assignment of the major peaks in the spectra was done using the patented "Targeted Profiling" technology of Chenomx NMR Suite. The discrimination observed based on PCA, PLS-DA, and multivariate variable selection analysis of the NMR spectra suggests that a complex mix of metabolites are present in vitreous fluid of different uveitic conditions as a result of the disease process. Collectively the data demonstrates the efficacy of metabolomic analysis to distinguish between ocular inflammatory diseases.

To see a pdf copy of this paper click here.

If you have published any material using Chenomx NMR Suite, please do not hesitate to let us know so that we can mention it in this newsletter. We would love to see it!

For other publications, case studies, news, and application notes using Chenomx NMR Suite click here.

Anyone can benefit from this powerful technology by using Chenomx metabolite profiling services or software.

It is only ten days until the 2010 Metabolomics Society conference! Chenomx is sponsoring and attending this conference taking place June 27th to July 1st, 2010, in Amsterdam, The Netherlands.

This is the first joint meeting linking the activities of a number of different organizations. The program will cover all the main scientific areas where metabolomics is already playing a key role including plants, humans, microbes, ecosystems, biomarkers, nutrition and more.

You can get more information by clicking here. Remember to drop by to see us! We look forward to meeting you there.

When using the Profiler module in Chenomx NMR Suite 6.1, you can export the 'starred' status of all compounds to a file using Export Profiled Data.

 

For a list of some Frequently Asked Questions click here.