In the November 2009 issue of the Journal of Proteome Research, there was a study published by Joyner et al. entitled Probing the Metabolic Aberrations Underlying Mutant Huntingtin Toxicity in Yeast and Assessing Their Degree of Preservation in Humans and Mice.

This paper used the patented "Targeted Profiling" technology of Chenomx NMR Suite to help find conserved metabolic biomarkers that are associated with mutant huntingtin gene expression. The mutant huntingtin protein is responsible for causing Huntington's disease; however, its mode of action is unknown. Moreover, the problem is further complicated due to a combination of loss-of-function effects (due to the gene's mutation) and gain-of-toxic-function properties attributable to the protein. In this comparative study, the researchers looked at data from yeast, mice, and humans in order to gain insight as to which metabolic disruptions arise from these two phenomena.  This allowed them to use that information in a follow-up metabolomics study that has just been completed to design new drugs to combat mutant huntingtin toxicity.
 
Here is what Dr. Robert Cichewicz (one of the authors of the above study) from the University of Oklahoma had to say about his experience with Chenomx NMR Suite: "The Chenomx software was instrumental to the success of the project and we were very happy with its performance.  I now am putting a new student to work using the metabolomics software to address other biochemical questions."
 
To see the abstract and sign-in to read this paper click here.

If you have published any material using Chenomx NMR Suite, please do not hesitate to let us know so that we can mention it in this newsletter. We would love to see it!

For other publications, case studies, news, and application notes using Chenomx NMR Suite click here.

Chenomx is proud to be a silver sponsor at the first International Metabolomics Symposium taking place March 10-12, 2010, in Freising-Weihenstephanin, Germany.

This informative conference will focus on new analytic methods, late-breaking discoveries, as well as challenges and pitfalls in metabolomics studies. Leading scientists will discuss the value of Metabolomics in basic science applications, in diagnostics and in nutrition and food research.  

You can register for this 2-1/2 day conference and get more information by clicking here.

When using the Library Manager module in Chenomx NMR Suite 6.0, you can edit a compound in the Compound Table by right-clicking on its entry and selecting Send to Compound Builder. As soon as you save your changes in Compound Builder, they are available in all Compound Sets containing the compound.

In 10 minutes, a hurricane releases more energy than all of the world's nuclear weapons combined.