Coming Soon: Chenomx NMR Suite 6.0!

The best is coming!  We are almost ready to release our latest Chenomx NMR Suite 6.0 version.  This new and powerful version will have many advanced features that allow you to fit spectra much faster and more efficiently than our past versions.  This is accomplished by the development of our "next generation" pH sensitive libraries.  It is now much easier to profile ("fit") spectra in Profiler, because our compound libraries will automatically calibrate many aspects of their own shapes to match each spectrum that is profiled.  You can save a lot of time and work through your data quicker with this latest edition!

Some other major improvements include:

• Processor now lets you specify a "pH Uncertainty" for each CNX file.  This allows you tell the software how "confident" you are about the pH value that you are assigning to a given spectrum.  So, for example, instead of telling it that a spectrum has a pH of "4.4", you could now tell it that the spectrum's pH is "4.4, plus or minus 0.3".   This new uncertainty amount (i.e. 0.3 in the previous example) is used each time the shapes of the new compounds are calibrated before fitting with them. The more confidence you have in a spectrum's pH, the more accurately each compound can be calibrated to match that spectrum.

• Compound Builder has been improved to allow Professional Edition users to create these "next generation" pH sensitive compounds. This way you can easily add new pH sensitive compounds to your own personalized libraries.
  

• Profiler now allows you to completely ignore transform windows when profiling compounds giving you greater flexibility while fitting.
  

This is just a summary of a few new features, but we will be sending you more information with all the details once it is released.  If you are a current customer and want to benefit from using the latest edition, be sure to renew your maintenance contract if it is not currently up to date.  If you have been considering purchasing a license of Chenomx NMR Suite for your metabolic profiling, then this latest edition might be exactly what you need! 

Remember, we also offer contract services if you would like to outsource you metabolic profiling research!
 
Please contact us today for pricing and more details.

In the May 2009 issue of the Journal of Proteome Research, there was a new study published by Hughes et al. entitled The Metabolomic Responses of Caenorhabditis elegans to Cadmium Are Largely Independent of Metallothionein Status, but Dominated by Changes in Cystathionine and Phytochelatins.  This paper used Chenomx NMR Suite for metabolite profiling and quantification using the patented "Targeted Profiling" technique. This was a study of cadmium exposure in C. elegans, and is still one of only a handful of metabolomic studies with this model organism. Using proton NMR spectroscopy and UPLC-MS, metabolic profiles were obtained from the model organism Caenorhabditis elegans exposed to sublethal concentrations of cadmium. The results suggest that a primary response to low levels of cadmium is the differential regulation of the C. elegans trans-sulfuration pathway, which channels the flux from methionine through cysteine into phytochelatin synthesis.

To see the abstract and sign-in to read this paper click here.

If you have published any material using Chenomx NMR Suite please let us know and we'll mention it in this newsletter!

For other publications, posters, and application notes using Chenomx NMR Suite click here.

The Fifth Annual International Conference of the Metabolomics Society will be held in Chenomx's hometown of Edmonton, Alberta, Canada from August 31-September 2, 2009.

When using the Profiler module in Chenomx NMR Suite 5.1 and you Export Profiled Concentrations, compounds with unknown concentrations (--) are not exported unless other spectra in the exported set have those compounds profiled, or you have chose to include compounds with no concentrations

No word in the English language rhymes with month, orange, silver or purple.

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