Both Chenomx metabolic profiling contract services and licensed software use Nuclear Magnetic Resonance (NMR) Spectroscopy to acquire the spectra.  Did you know NMR technology offers some unique advantages over the alternative Mass Spectrometry (MS) method?  Some of which include:

· Fully quantitative - NMR has a significant advantage in simultaneously identifying and quantifying metabolites of interest.

· Non-destructive testing - NMR is inherently non-destructive so samples can be used again for further analysis.

· Sample preparation is minimized - NMR requires little sample preparation before acquisition so time and money are saved.  Furthermore, easier sample preparation ensures more reproducible results since fewer variables are at risk.

· Within-lab and cross-lab reproducible results -  Results are reproducible within and across labs, as well as across different field strengths, making NMR a perfect choice for multi-lab collaborations and long term studies.

· Non-selective - NMR is an unbiased universal detector ensuring that the integrity of your results is not compromised.  There are also certain metabolites that are only identifiable using NMR technology such as GTP, ADP, AMP, ATP, NAD+, Acetic acid, Ethanol, Formate, Pyruvate, Guanosine, Taurine, Choline, Creatine, Creatinine, and more!

· Cost effective solution - Not only are our services a fraction of the cost of MS technology, but we also offer metabolic profiling on small studies with few samples so you don't have to spend a fortune trying it out. 

Our patented "Targeted Profiling" technology combined with NMR spectroscopy ensures a powerful tool that can be used to provide a fast and non-selective view of the contents of a fluid sample. NMR has also been used extensively in biomarker discovery studies.  For a comprehensive list of publications using Chenomx NMR Suite technology please visit our publications page.

Sending samples for analysis or purchasing an in-house license of Chenomx NMR Suite is an easy process!  Contact us today to learn more about how we can help you discover more from your research.

 In January 2009, a new study published in PLoS ONE by Tiziani et al. entitled Metabolomic Profiling of Drug Responses in Acute Myeloid Leukaemia Cell Lines.  This paper used Chenomx NMR Suite to assign NMR resonances which examined the effect of bezafibrate (BEZ)and medroxyprogesterone acetate (MPA) on three acute myeloid leukaemia (AML) cell lines and shed light on the underlying mechanism of action. Drug treatments engendered common metabolic changes, most markedly in the response to the combination of BEZ and MPA. The findings demonstrated that metabolite profiles represent highly sensitive markers for genomic differences between cells and their responses to external stimuli. This opens new perspectives to use metabolic profiling as a tool to study the rational redeployment of drugs in new disease settings.

To see the abstract and sign-in to read this paper click here.

If you have published any material using Chenomx NMR Suite please let us know and we'll mention it in this newsletter!

For other publications, posters, and application notes using Chenomx NMR Suite click here.

When using the Profiler module in Chenomx NMR Suite 5.1, you can adjust the display of compound lines through the Legend view in the Sidebar, including setting custom colors, pinning compounds and selecting a compound for use in profiling.

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