The Chenomx MetaProfile is a
cost-effective method for measuring concentrations of many metabolites found in
cell extract samples. The Chenomx MetaProfile is designed for repeatability and
reproducibility, and can be used for both large and small studies. Results are fully
quantitative, allowing data to be compared across long-term
studies.
Using Chenomx's patented
targeted profiling technique, NMR spectra can be
easily translated into compound information relevant to
the underlying biology. Customers using MetaProfiles obtained from Chenomx
technology include some of the world's largest life sciences companies, as well
as leading universities in the United States, Europe, and Asia.
Chenomx has experience with
various cell types, including E.coli, CHO (Chinese Hamster Ovary
cells), and insect cells. Chenomx
services will offer a wide range of sample preparation options, including full cell lysis
protocols from pellets (whole cells) to NMR ready samples. The Chenomx
MetaProfile produces a metabolic
profile, which can be used to monitor the
effects of disease, diet, toxins or pharmaceuticals on an organism. The
Chenomx MetaProfile is particularly valuable in understanding effects on
metabolic pathways since it is an inherently quantitative method providing a
global view of the metabolites. Applications include:
· Toxicology and safety assessment
- early identification of toxic effects
· Drug metabolism studies -
metabolic pathway analysis, pharmacokinetics
· Biologics Process Development -
including bioreactor media formulation to cellular metabolism and
monitoring
The Chenomx platform is also ideal for many other sample types including
urine, plasma/
serum,
saliva,
CSF, and more.
Contact us to learn more about our patented
services and
software.
