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New Book: 
Your Drug-Free Guide to Healthy Weight Loss
Drug Free Guide to Healthy Weight Loss

  Wisdom + Wit = Wonderful!  Heather Caruso's latest book, "Your Drug Free Guide to Healthy Weight Loss" is a book packed with information and hilarity and is a guaranteed path to a slimmer, healthier you. From how to psyche yourself up to begin the process, to finding delicious foods to eat, providing recipes and appropriate homeopathic remedies to take, this book is an easy-to-read guide with fun anecdotes and friendly motivation to take you to that level of health and fitness you dream of but never quite get to! Everyone needs a good friend like Heather - with this book, you have that friend - and before you know it, you'll also have that weight loss goal sheet marked "Completed"!
~Sandra Lewis, Life Coach, Advanced EFT Practitioner, Homeopath and author of "Getting It Right: Cutting to the Chase and Creating the Life Your Want
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 April 2010 Volume 1 

Welcome to Homeopathic Times, read our next part on how to lose weight and feel great for 2010. Are you ready to get your  body in shape for shorts and t-shirt weather this summer?  
Lose Weight, Feel Great!
Summer Body Here We Come!  

bikingI have been researching the many healthy ways that people can lose weight and keep it off. I have culminated this research as well my clinical experience into a new book which is now available as an ebook called "Your Drug Free Guide to Healthy Weight Loss". (Softcover can be pre-ordered today and will arrive in 2 weeks)
If you have been following each monthly newsletter I have been highlighting the many reasons for weight gain and how we can improve our health so that we can achieve a healthy body weight. Last month we highlighted how to move your body to maintain a normal body weight. 
 My new book is finally out and you can tailor suit your healthy weight loss goals to your own specific needs. For more information click here 
Buy two books (softcover copy) called Your Drug Free Guide to Digestive Health and Your Drug Free Guide to Healthy Weight Loss and save $10.00 off the regular price. Buy it now
(Cost $47.74)
Buy two digital e-books called Your Drug Free Guide to Digestive Health and Your Drug Free Guide to Healthy Weight Loss and save $10.00 off the regular price. Buy it now (Cost $24.97)


We have been working hard on getting our online e-store up and running. Have a look at it online. It is functional however we are adding inventory daily. In our newsletters we be highlighting the cream of the crop supplements for optimal health  Click here to view our online store.

      Here is our first supplement spotlight:
Learn Why There is all the Buzz about Resveratrol; AOR ACTA RESVERATROL Click here for more info on this supplement from AOR 
Acta Resveratrol    There is no doubt that many among us, in the context of dinner-party banter or some other setting conducive to the transfer of anecdotal wisdom, have heard that a glass of wine a day is good for your health. 'A healthy heart and a long life' is usually the jist of this particular nugget of scientifically secular populist enlightenment. The long life that is inferred is attributable to a substance that the scientifically observant elite have identified as resveratrol, a phytonutrient originating -in this case - in the vinyards. Resveratrol, in turn, elicits this wondrous effect largely by mimicking many of the biological chain of events seen in the practice of Calorie Restriction Optimum Nutrition (CRON), or simply Caloric Restriction (CR).
       Caloric Restriction (CR) is the only proven method of increasing life span in numerous and diverse species, from yeast, worms, fruit flies, spiders, rodents, all the way up to primates. Calorie restriction refers to an approximately 40% reduction in caloric intake, usually accompanied by a maintenance level of nutrients. The institutions that have conducted this research include Cornell and Harvard University, as well as the prestigious Massachusetts Institute of Technology (MIT) - testimony to the credibility behind Caloric Restriction. This research has branched out to encompass the study of 'caloric restriction mimetics'. These are compounds that enable organisms to parallel many of the beneficial biological effects of a caloric restriction diet, and among the most prominent of these is a substance known as resveratrol. Resveratrol is a naturally occurring polyphenolic compound found in various berries (cranberry, blueberry, grapes), peanuts, rhubarb and a number of oriental herbs including the Japanese Giant Knotweed (Polygunum cuspidatum).
     Studies with resveratrol have reported a diverse range of physiological and biochemical effects, particularly in the areas of heart health, cancer, immunity and inflammation. Other beneficial cardiovascular effects include the reduction of cholesterol and triglycerides, dilation of blood vessels (hence a blood pressure lowering effect), platelets being less "sticky" (anti-aggregatory effect) - and consequently a lower incidence of atheroma or plaque formation and a reduced rate of strokes and heart attacks. Resveratrol exerts anti-oxidant effects by quenching free radicals (including reactive oxygen species) that act as cellular terrorists, reducing the oxidation of LDL particles, which many believe to be the initiating event in atherosclerosis or hardening of the arteries. Resveratrol also inhibits unfavourable cellular proliferation and up-regulates apoptosis or programmed cell death. 
      Resveratrol has been shown to down-regulate the production of chemicals (cytokines) involved in the cause, signaling and amplification of inflammation. Resveratrol's anti-cancer effects have been shown to occur at all three stages of cancer - initiation, promotion and progression. Prevention of blood flow to the tumour (angiogenesis) restricting the growth and spread of the cancer cells and inhibition of various enzymes involved (e.g. cyclooxygenses or ornithine decarboxylase) have been attributed to resveratrol. Finally, the modulation of the activity of the two groups of enzymes - Phase 1 and Phase 2 - also plays an important role in the detoxification and anti-cancer effects of resveratrol. The Phase 1 family of enzymes normally makes compounds more carcinogenic or toxic and resveratrol has an inhibiting effect on them, thereby preventing carcinogen formation. Alternatively, stimulation of the Phase 2 class of enzymes help facilitate the removal of toxins and carcinogens from the body by making these compounds even more soluble and easier for excretion.
The plants that produce resveratrol do so as a response to stressors such as fungal infection or ultra violet exposure. Resveratrol has been shown to enhance life extension much like caloric restriction in yeast (70%), worms (18%), fruit flies (30%), and fish (60%). The mechanism may be similar to sirtuin activation. There is considerable excitement regarding the use of resveratrol as a CR Mimetic. A recent study published in the prestigious journal Nature jointly by Harvard University and the National Institute of Aging demonstrated that resveratrol in high doses offset the effects of an unhealthy high-calorie diet in mice. Resveratrol is a molecule that occurs in nature in two forms or as mirror-images, namely the trans and cis forms. It is the trans version of the resveratrol that is the active form that has been used in all the investigations. The cis form may be at best inactive or at worst inhibit the activity of its mirror image - the trans form. There are high quality, naturally extracted sources that yield 98% plus trans activity.
As we conclude, we are reminded of the 'one glass of wine a day for longer life' anecdote. In order to obtain the substance identified as responsible for this effect in amounts that are commensurate with even the most conservative trials, one needs to consume approximately 1,000 glasses of red wine each day! A noble goal for some, but perhaps one capsule containing enough resveratrol to equal that found in approximately 450 glasses of red wine might be a more practical start.

Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Front Biosci. 2007 Sep 1;12:4839-54.
Shankar S, Singh G, Srivastava RK.
Resveratrol, a polyphenol found in numerous plant species, including mulberries, peanuts and grapes, has shown to possess chemopreventive properties against several cancers, and cardiovascular diseases. Recently, resveratrol has been shown to have positive effects on age longevity, lipid levels and a preventative quality against certain cancers and viral infections. Resveratrol induces apoptosis by up-regulating the expression of Bax, Bak, PUMA, Noxa, Bim, p53, TRAIL, TRAIL-R1/DR4 and TRAIL-R2/DR5 and simultaneously down-regulating the expression of Bcl-2, Bcl-XL, Mcl-1 and survivin. Resveratrol causes growth arrest at G1 and G1/S phases of cell cycle by inducing the expression of CDK inhibitors p21/WAF1/CIP1 and p27/KIP1. Resveratrol has also been shown to reduce inflammation via inhibition of prostaglandin production, cyclooxygenase-2 activity, and nuclear factor-kappaB activity. Modulation of cell signaling pathway by resveratrol explains its diverse bioactivities related with human health. Resveratrol also potentiates the apoptotic effects of cytokines, chemotherapeutic agents and gamma-radiation. Pharmacokinetic and pharmacodynamic studies demonstrated that the main target organs of resveratrol are liver and kidney, and it is metabolized by hydroxylation, glucuronidation, sulfation and hydrogenation. As a chemoprevention agent, resveratrol has been shown to inhibit tumor initiation, promotion, and progression. There is growing evidence that resveratrol can prevent or delay the onset of various cancers, heart diseases, ischemic and chemically induced injuries, pathological inflammation and viral infections. This review summarizes the molecular mechanisms of resveratrol and its clinical benefits for human diseases.
Effects of resveratrol in inflammatory arthritis. Inflammation. 2007 Apr;30(1-2):1-6.
Elmali N, Baysal O, Harma A, Esenkaya I, Mizrak B.
Nuclear factor kappa B (NF-kappaB), is a pivotal transcription factor involved in the activation of the TNF-alpha and IL-1beta genes. Activation of NF-kappaB in synovial cells is a feature seen in arthritis patients. Resveratrol, a polyphenolic, natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-alpha and IL-1beta induced NF-kappaB activation. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental rabbit inflammatory arthritis model. MATERIALS AND METHODS: Arthritis was induced by intra-articular injection of three times of 50 mug lipopolysaccharide (LPS) at day 0, 4 and 8 at 4-day intervals into the knee joints of rabbits. To the test group, 10 muMol/kg resveratrol in the DMSO was injected in the knees at day 0 and then it was continued once daily for 2 weeks. To the control group the same time and amount of DMSO was injected the knees of rabbits. All rabbits were killed 1 week after the last injection and cartilage tissue and synovium were evaluated with semiquantitative scoring histologically. RESULTS: According to control group in the resveratrol group, significantly decreased cartilage destruction was determined by H&E staining (p = 0.04). Loss of matrix proteoglycan content in the cartilage was much lower, as determined by safranin O staining (p = 0.03). We also observed marked synovial inflammation after intra-articular injection to control knees, but not in the resveratrol treated group knees (p = 0.01). CONCLUSION: This study suggests that intra-articular injection of resveratrol may protect cartilage against the development of experimentally induced IA.
Resveratrol inhibits pancreatic cancer cell proliferation through transcriptional induction of macrophage inhibitory cytokine-1.
J Surg Res. 2007 Apr;138(2):163-9. Epub 2007 Jan 25.
Golkar L, Ding XZ, Ujiki MB, Salabat MR, Kelly DL, Scholtens D, Fought AJ, Bentrem DJ, Talamonti MS, Bell RH, Adrian TE.
INTRODUCTION: Resveratrol is a phenolic compound found in grape skins, mulberries, and certain nuts that has been shown to have antitumorigenic and anti-inflammatory properties. Macrophage inhibitory cytokine (MIC-1) is a member of the transforming growth factor beta (TGF-beta) superfamily that has been shown to have antitumorigenic activity and is up-regulated in resveratrol-treated cancer cells. Resveratrol inhibits proliferation of human pancreatic cancer cells; however, the exact mechanism of action is not known. In this study, we investigated the role of MIC-1 in resveratrol-induced growth inhibition of human pancreatic cancer cell lines.
METHODS AND RESULTS: Proliferation assays conducted with resveratrol-treated human pancreatic cancer cell lines (CD18 and S2-013) at 24, 48, and 72 h revealed inhibition of cell proliferation compared to controls. Using oligonucleotide microarray analysis, we identified marked up-regulation of MIC-1 gene expression in resveratrol-treated human pancreatic cancer S2-013 cells. Real-time RT-PCR performed in CD18 and S2-013 cells treated with resveratrol (0-100 mum) for 24 h confirmed concentration and time-dependent up-regulation of expression of one particular gene, MIC-1. Both cell lines pretreated with actinomycin D (a transcriptional inhibitor) and then resveratrol had reduced up-regulation of MIC-1 gene expression compared to those treated with resveratrol alone. Finally, resveratrol-induced growth inhibition was abolished in CD18 cells transfected with MIC-1 short interfering RNA.
CONCLUSIONS: Resveratrol up-regulates MIC-1 gene expression in part at the transcriptional level in pancreatic cancer cells. Furthermore, MIC-1 appears to play a key role in resveratrol-induced growth inhibition in these cells.

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.
Copyright 2005, Advanced Orthomolecular Research
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