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Spacedoc Newsletter April 23, 2011
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| Statin Associated Myopathy and Exercise | |
 by Duane Graveline, MD, MPH
Not only can statin drugs cause myopathy ( muscle disease ) of varying degrees but this myopathy is greatly exacerbated by exercise. The effect of exercise is such that most experienced athletes will not use statins for fear of predisposition to muscle side effects of all kinds.
The severity of the muscle side effects from statins vary widely from relatively benign CPK elevation without symptoms, to muscle tenderness, aching, soreness and pain, and rarely, even to death from rhabdomyolysis.
Read the full 'Statin Associated Myopathy and Exercise' article here:
Statin Associated Myopathy and Exercise
Duane Graveline MD MPH
Former USAF Flight Surgeon
Former NASA Astronaut
Retired Family Doctor
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Forgetfulness, Disorientation, Confusion and Statins
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by Duane Graveline, MD, MPH
The advent of the stronger statin drugs in the past decade has contributed to a flood of reports of impaired cognition. These complaints range from transient global amnesia, to aggravation of pre-existing senility to forgetfulness, disorientation and confusion.
The mechanism of this side effect is clearly rooted in the biosynthesis of cholesterol and fundamental to neurophysiologic mechanisms. Only in the past several years have we learned the importance of cholesterol in brain function.
Imagine, cholesterol, the same cholesterol we have been led by the pharmaceutical industry to be public health enemy number one, now proven to be absolutely vital in the formation and function of the trillions of synapses in our brains.
Read the full 'Forgetfulness, Disorientation, Confusion and Statins' article here:
Forgetfulness, Disorientation, Confusion and Statins
Duane Graveline MD MPH
Former USAF Flight Surgeon
Former NASA Astronaut
Retired Family Doctor
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| Causes of Statin Side Effects | |
by Duane Graveline, MD, MPH
I often refer to the mevalonate pathway ( also known as the HMG-CoA reductase pathway ) as all statins are reductase inhibitors and therefore exert their effect at the very beginning of the mevalonate pathway, the location of this key reductase step.
When statin drug manufacturers make the claim of reduction of cholesterol synthesis, it is based upon inhibition of the mevalonate pathway, shared by the other major elements such as CoQ10 and dolichols.
This diagram helps to explain the mevalonate pathway and what inhibition by statins can lead to.
View 'Causes of Statin Side Effects' here:
Causes of Statin Side Effects
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| e-Books by Dr Duane Graveline, M.D. | |
e-Books offer a lower cost way to get the same information as in the print versions, allow readers from all over the world instant access, and now you do not even need an electronic bookreader as these Kindle editions can be read on any computer device like smart phones including the iPhone, tablet computers including the iPad, laptops and desktop PCs and Macs.
The Statin Damage Crisis
Statin Drugs Side Effects and the Misguided War on Cholesterol
LipitorŪ Thief of Memory
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| Books by Dr Duane Graveline, MD MPH | | Advertisement | The Statin Damage Crisis by Duane Graveline MD MPH Paperback  Buy Now
Statin Drugs Side Effects and the Misguided War on Cholesterol by Duane Graveline MD MPH Paperback
 Lipitor Thief of Memory by Duane Graveline by Duane Graveline, M.D. Paperback |
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