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Spacedoc Newsletter
February 24, 2009
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| Causes of Statin Side Effects |
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 This article contains a chart and comprehensive listing of major statin side effects.
All statins are reductase inhibitors and therefore exert their effect at the very beginning of the mevalonate pathway, the location of this key reductase step. Cholesterol inhibition is just one of the effects of statin drugs. Added to this are interruptions to five other critical metabolic functions. Each of these are identified along with the potential side effects that could occur when they are inhibited or disrupted. Read about the Causes of Statin Drug Side Effects here
Duane Graveline MD MPHFormer USAF Flight Surgeon, Former NASA Astronaut, Retired Family Doctor
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| Pitavastatin |
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Pitavastatin is just another statin drug, meaning it is a reductase inhibitor, designed to reduce cholesterol by the blocking of the mevalonate pathway. It was developed in Japan in 2003 at about the same time Crestor was being developed and marketed in the United States. Because pitavastatin was developed based partially upon a slight variation from other statins in how it is metabolized in the human body, the original expectations were that it might be a useful alternative when certain side effects preclude the use of other statins. Read the full article here
Duane Graveline MD MPH
Former USAF Flight Surgeon, Former NASA Astronaut, Retired Family Doctor |
| Books by Dr Duane Graveline MD MPH |
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"The Statin Damage Crisis" by Dr Duane Graveline
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 Dr Graveline's third book on statins called "The Statin Damage Crisis" will be available in March.
Originally planned as a new edition to "Statin Drugs Side Effects," it will instead be released as a stand alone title so that the highly relevant material in "SDSE" will still be available.
Dr Graveline wrote the following introduction to this latest title:
Early on my NASA doctors told me my amnesia response to statins was nothing but a coincidence but I persevered to write my first book, "Lipitor, Thief of Memory" and now find that over 1,000 cases of amnesia and memory loss have been reported to the FDA, just from Lipitor alone.
Then, I learned of statin damage to nerves and muscles and profound behavioral and personality changes, demanding I write a second book, "Statin Drugs Side Effects." Even this broadly encompassing book was insufficient to describe what I have learned more recently of the truly dark side of statins - their ability to alter the very fabric of our makeup.
I had long wondered why our muscle and nerve damage seemed permanent and even progressive like my own ALS-like condition. Now I have found that the ultimate effect of statins on CoQ10 and dolichols is to damage the DNA of the mitochondrial life-force within our cells - mitochondrial mutation masquerading as premature old age.
Duane Graveline MD MPH
Former USAF Flight Surgeon, Former NASA Astronaut, Retired Family Doctor Visit the books page |
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Duane Graveline MD MPH
Former USAF Flight Surgeon, Former NASA Astronaut, Retired Family Doctor
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