Issue: #5January 2012



- Expediting a Pre-Clinical Component of Drug Discovery, Production of Key Metabolites via Ex vivo Syntheses  
- 3 Easy Ways to Search the Adesis Catalog
- Visit Adesis at Informex 2012-Now Scheduling Meetings
- New Compounds for January -  Always In Stock!


In This Issue
Production of Metabolites via ex vivo syntheses
3 Easy Ways to Search Our Online Catalog
Informex 2012
Compounds of the Month
January Promotion


catalog e-news



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Adesis Whitepaper

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Efficient Methods for Regioselective 

Functionalization of 

6-Substituted Furo[3,2-b] pyridines for Indole Isosteres.  



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Expediting a Pre-Clinical

Component of Drug

Discovery, Production of 

Key Metabolites via Ex vivo Syntheses



 As an adjunct to standard organic synthetic approaches, Adesis scientists have developed expedient scale-up routes for metabolites by the use of porcine liver homogenates or perfused livers as an ex vivo reactor system.  The rationale to use porcine hepatic components is based on i) high metabolic homology to human metabolism, ii) ready availability of fresh porcine hepatic components and iii) direct use of an experimental agent.  This approach is not intended to substitute for total syntheses approaches, as much as it facilitates isolation of adequate quantities of key metabolites (milligrams to grams) for unambiguous structure determination and for initial in vitro and in vivo bioprofiling. Ex vivo synthesis is another research offering in the Adesis armamentarium of specialized chemistry tools.


Metabolism of a drug is an obligatory process after it has reached the primary site of pharmacological action. Depending on the metabolic process(es) involved, the duration of a drug's primary action may be enhanced and/or untoward toxicities can occur.  Thus, an orderly elimination process for foreign molecules is necessary.  Mammalian drug and xenobiotic metabolism is primarily mediated by metabolic enzymes in the liver, and lesser degree in the kidneys, lungs and gastro-intestinal tract [1].  Such processes are defined as Phase I (functionalization processes involving cytochrome P450 oxidases[2,3]) and Phase II (conjugation reactions of aqueous solubilization moieties involving UDP-glucuronosyltransfer-ases[4] and glutathione S-transferases). The Phase II processes provide conjugates that facilitate elimination of the drugs.




3 Easy Ways to Search Our Online Catalog 



Informex 2012



Informex New Orleans - February 14-17, 2012 

Come meet the Adesis team (Booth #946) or schedule a meeting prior to the show Schedule Meeting


Compounds of the Month

Hot New Heterocycles 

Our catalog currently contains almost 50 novel substituted pyrido-dioxanes.  Have you explored these yet?   What is the impact of the ethylene bridge?  We also have move than 40 ortho dimethoxy substituted pyridines.  Be sure to explore our full catalog for all your structure-activity relationship needs.   




To see all of our new heterocycles Click here 




About Adesis

Adesis, Inc. is a contract research organization (CRO) supporting the pharmaceutical and biopharmaceutical industry, biomaterials and catalysts industry. 


The life science industry has embraced the philosophy of outsourcing reference standards (competitor's drugs), targets, scaffolds, building blocks and advanced intermediates. Outsourcing allows medicinal chemists to focus on design and assembly of new targets for pharmacological evaluation and streamlines the early stage drug discovery process. Similarly, other chemistry-based research organizations (catalysts, biomaterials and fragrances) have accepted similar modus of operendi in order to maximize cost controls, while having timely project successes.


The core foundation of Adesis, Inc. is attributed to our experienced chemists with the expertise to conduct complex multi-step synthetic sequences (typical range of 2 - 20 steps).



Buy 3 Get 1 Free

January Promotion: 

Buy any 3 one (1) gram  catalog compounds in January, mention this coupon at time of purchase, and get one (1 ) gram of any compound of equal or lesser value free...It's that easy.


Please call Jack Church to place your order: 302-323-6305 or email

Offer Expires: February 15th 2012 
Only one offer per person 

We hope you have enjoyed reading our Adesis newsletter.  We welcome your comments.


With Best Wishes,


Paul Beard


If you are interested in how your company can do business with Adesis or to learn more about our capabilities, please contact one of the members of our business development team.


Ronald G. Yarger, PhD

Director, Business Development 

Ph. 302-261-3383; Mobile 302-358-8837 



Paul Beard, MBA BS 

Business Development Associate 

Ph. 302-323-6314; Mobile 302-383-5918