September, 2012
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Society of Biological Psychiatry
"Scientists collaborating to eliminate the suffering of mental illness."
In This Issue
SOBP Vision Statement
Message from the Editor
2013 Meeting Announcement
2013 Awards
2013 Membership Renewals
Journal Updates
Welcome New Members
Other Meetings of Interest
Get Involved
Add SOBP to your Contacts
SOBP Contact Information
SOBP Vision Statement

The vision of the Society of Biological Psychiatry is to integrate, advance, and promulgate science relevant to psychiatric disorders, in order to reduce or prevent the suffering of people with these conditions.



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In This Issue 

(A brief summary of articles in current issue)

Message from the Editor

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Let's Leave our Developing Brains in San Francisco


As recently announced, the theme for this year's annual SOBP meeting in San Francisco is "Neuroplasticity and the Changing Brain: Development, Pathobiology and Therapeutics." I couldn't imagine a more timely discussion, given my repeated call in this newsletter (and the goal of SOBP conferences) to develop new paradigms for understanding mental illness in order to improve approaches to treatment development. We, as a field, have often approached the disorders we study as if they are static - i.e., that how they exist today is how they have always existed. Consequently, most of our models and clinical neuroscience research has not examined how changes in brain development and plasticity may underlie the illnesses we are trying to understand. Longitudinal human studies are relatively rare. This shortcoming is surprising when one considers that most (if not all) of the major illnesses we study arise during critical developmental periods (e.g., bipolar disorder, schizophrenia, Alzheimer's disease) or result from plastic brain changes to environmental events (e.g., PTSD, major depression). How can an annual meeting address this shortcoming?

          The first way to use the meeting most successfully is to truly focus the science we submit around the theme. In the end, the program committee cannot craft poster sessions and symposia from anything other than what is submitted. I would like to challenge attendees to truly move out of their typical comfort zone (unless it actually involves developmental or plasticity research) and provide examples of truly novel analyses or interpretations of existing or evolving datasets that meet the theme. Second, we need to expose ourselves to new ideas. To do so, we need to attract additional individuals to our meeting. Invite to the meeting a child psychiatrist, developmental neurobiologist, learning investigator or other individuals with interests in our thematic area who typically would not attend the meeting. If we can add new people, we can add new ideas that might help us advance our science. Think about interesting people at your institution that might add to this discussion and send them an annual meeting announcement or even this newsletter.

          Annual meetings are useful as places to sit and learn about other's work in our areas of interest, socialize with old friends or visit a new city, but the real value is if connections made at the meeting lead to new science and better discovery. It is truly time to place the illnesses we study within the context of the neurodevelopmental trajectories that almost certainly contribute to disease onset and expression. Our patients deserve nothing less.  

          Thanks and see you in San Francisco.


Best Wishes

Steve Strakowski, MD
Senior Associate Dean for Research

UC Health Vice President for Research

Professor and Chair, Department of Psychiatry & Behavioral Neuroscience    

2013 Meeting Announcement

Society of Biological Psychiatry's 68th Annual Meeting

May 16-18, 2013 

Hilton San Francisco - Union Square 

San Francisco, California 




A Message from...

  Ressler                                         Scott Rauch

Kerry Ressler, MD, PhD                           and            Scott Rauch, MD

Chair, Scientific Program Committee                      President, Society of Biological Psychiatry


It is clearly an exciting time for the Society of Biological Psychiatry and its members. Soon after our remarkably successful meeting in Philadelphia in 2012, the Program Committee has been hard at work putting together what promises to be an outstanding and stimulating program for 2013 in San Francisco. At the 2012 meeting, the program focused on Systems Neurosciences approaches, from basic to clinical that help shape current thinking in mental illness. For 2013, the Program committee will continue this trend of integrative thinking, focusing on neuroplasticity, the ability to change synaptic strength and circuit connectivity, which is critical for normal brain development, mental health and recovery. Thus, our integrative theme for 2013 is: Neuroplasticity & the Changing Brain: Development, Pathobiology &Therapeutics.  We look forward to a thrilling 2013 meeting in San Francisco to examine and discuss cutting edge work on how our growing understanding of neuroplasticity is leading to novel and potentially transformational ways to 'change the brain' to improve mental health.   Plasticity and the dynamic aspects of brain structure and function hold the keys to understanding the pathogenesis of disease, as well as normal development and innovative therapies. The theme of plasticity spans molecular, synaptic, cellular, neurocircuitry, and behavioral levels of analyses, and it traverses the lifespan from early development to geriatric aging, as well as intergenerational mechanisms of transmission.
          We already have commitments from outstanding world-renown plenary speakers who will focus on aspects of neuroplasticity that are most relevant to improving mental health and for understanding the concepts of plasticity across circuits and systems. The first session will focus on Developmental Plasticity & Intergenerational Transmission. A second session will focus on Plasticity & Pathology, and the final session will discuss The Future of Therapy and Recovery: Leveraging Plasticity.    
          The Program Committee is in full swing, and we expect our shared passion and enthusiasm to spread to all members of the Society as you plan your symposia and presentations and begin to focus on a trip to the marvelous city of San Francisco, CA. San Francisco is always a beautiful and engaging city to visit, particularly in May. Famous for scenic vistas, cultural attractions, diverse communities and world-class cuisine, San Francisco's landmarks include the Golden Gate Bridge, cable cars, Fisherman's Wharf, Alcatraz, Chinatown, Union Square, North Beach, the Castro district and Mission Dolores. The city and our convention hotel, Hilton Union Square, are looking forward to hosting SOBP next May.
          It is most important now
to start planning symposia submissions. While we all look forward to the plenary sessions, the symposia represent the heart of the Society's meeting, where members and other scientists present their most recent research findings as springboards for vibrant discussion. The diversity of presentations at each year's meeting, focused on a broad range of illnesses and modes of inquiry, is the lifeblood of the meeting. As a result, the Program Committee is eagerly anticipating the upcoming wave of submissions. The deadline for symposia proposals is October 25th. After the symposium proposal has been entered, the deadline for the individual abstracts within a symposium is November 1st. The deadline for oral and poster abstracts is December 13th.   Submission instructions are available at
          With every day, we are more excited about the coming meeting. Please do plan on joining our colleagues in preparing a symposium, oral or poster submission for this exciting meeting of progress and discovery!


Mark Your Calendars - Important Deadlines


September 1, 2012                           Call for Abstracts Opens

October 25, 2012                              Symposia Overall Proposal Due

November 1, 2012                            Symposia Individual Abstracts Due

December 13, 2012                          Oral and Poster Abstracts Due


Visit SOBP.ORG frequently for updated program information. 
Questions?  Email or call 904-953-2842.   


2013 Awards - Deadline November 30th

  2013 Travel Fellowships & Other Awards - Deadline November 30th 

 Apply for one of these prestigious awards 


Domestic Travel Fellowship Award - $1500 Travel Fellowship Award 

For promising young investigators (within North America) who would benefit from attending the meeting

International Travel Fellowship Award - $1500 Travel Fellowship Award
For promising young investigators (outside of North America) who would benefit from attending the meeting
Humanitarian Award
          For service and advocacy to mental illness

Gold Medal Award

          To honor pioneering contributions in the field of Biological Psychiatry

George N. Thompson Award          
          To honor members of the Society who have given outstanding service to the organization

A. E. Bennett Research Award

          To stimulate research in biological psychiatry by young investigators

 Ziskind-Somerfeld Research Award- $5,000 Award 

          To stimulate research in biological psychiatry 

2013 Mentor/Mentee Program - Apply Now

The 2012 Education Program was a wonderful success based on feedback from both the Junior Investigators (JIs) involved and SOBP members who participated as mentors alike.   Using the program for the travel awardees as a springboard, the Education Committee (formerly Education Taskforce), chaired by Linda Carpenter and Maria Oquendo, implemented several novel features. All self identified JIs were assigned a mentor based on their requests for matching and mentors and mentees all met at least once during the meeting.  Mentors were provided a "drink voucher" to encourage "offline" conversations over coffee or cocktails while at the meeting. However, mentors were able to not only counsel JIs, but also helped them network by introducing them to other senior members.  JIs were also welcomed and recognized at the President's Reception on Wednesday evening. Of note, Council approved an expansion of the travel award program to extend access for potential JIs and several strategies for improving visibility of the program are being implemented. The 2013 meeting promises to have an even more extensive program geared towards JIs to enhance interest in the Society and feed the pipeline of new investigators so critical to the field.

Annual Membership Dues Decreased

The Society is pleased to announce the 2013 annual membership dues (for Members and Associate Members) decreased from $250 to $195.  Student membership fees decreased from $125 to $95. 


This decrease was approved by your council for two reasons.  First and most important, the Society realizes many members pay their membership dues out of their own pockets, not out of their grants or by their institutions. Council listened to the concerns expressed by members about rising costs and decreased budgets. Second, sound financial investments along with lean and efficient operations have allowed the Society to achieve its targeted endowment, allowing the Society to invest those earnings back into the members and programs by decreasing your dues.


The Society understands you have a choice when deciding which professional membership to renew each year.  This decrease is a "thank you" to our members who are working hard to eliminate the suffering of mental illness and demonstrates our commitment to the Society's members' success.


Stay connected and engaged - Renew your membership for 2013 by December 15th and continue to receive your member benefits: 
  • Subscription, print and on-line, to our top-rated journal, Biological Psychiatry
  • Reduced registration fees for the annual meeting
  • No abstract submission fee ($40 for non-members)
  • Sponsor abstracts and membership applications
  • Access to members-only on-line tools
  • Leadership opportunities
  • Recognition and affiliation with a premier organization
  • Networking and professional development

Renew on-line today at 

Invoices will be emailed to all members starting in September.  If you need your login information or a hard copy of your invoice for payment, email
Journal Updates


Journal Cover

Important Findings Published in Biological Psychiatry

By Caleb M. Adler, MD.  


July 1, 2012


Commentary by Shigeto Yamamoto, Shigeru Morinobu, Yosuke Fujita, and Shigeto Yamawaki

Stafford JM, Raybuck JD, Ryabinin AE, et al (2012). Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction. Biol Psychiatry 72: 25-33.

Dr. Stafford and colleagues address the hypothesis that increased histone acetylation enhances memory consolidation. They use a mouse model in which intrahippocampal and intra-medial prefrontal administrations of the histone deacetylase inhibitor, sodium butyrate (NaB) were applied after contextual fear conditioning and extinction. They found NaB administration in the hippocampus was more closely associated with memory extinction than memory consolidation. In the commentary, Dr. Yamamoto and colleagues review the background of this work and compare these findings with other recent studies, suggesting potential clinical directions for future research.


Commentary by Patrick O. McGowan

Labonte B, Yerko V, Gross J, et al (2012). Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry 72: 41-48.

In this paper, Dr. Labonte and colleagues follow up previous observations of epigenetic influences in the glucocorticoid receptor (GR). They find evidence for region-specific changes in in the hippocampal GR of suicide completers with a history of abuse, compared with individual without an abuse history who completed suicide, and other controls. In contrast, no group differences were observed in anterior cingulate GR. The commentary discusses the role of epigenetics in regulating long-term response to early life events, while high-lighting potential complications inherent in studies of this kind.


Commentary by Kelimer Lebron-Milad, Bronwyn M. Graham, and Mohammed R. Milad

Glover EM, Jovanovic T, Mercer KB, et al (2012). Estrogen levels are associated with extinction deficits in women with posttraumatic stress disorder. Biol Psychiatry 72: 19-24.

Several lines of evidence have suggested the potential influence of estrogen levels in fear extinction, and potentially post-traumatic stress disorder (PTSD). In this paper, the authors observed that women with PTSD and low estrogen levels showed greater fear-potentiated startle responses during fear extinction training than did women without PTSD. This difference was not observed in women with PTSD and high estrogen levels. The commentary notes how these findings compare with previous work by these authors and others; and discusses the potential implications of these findings, both for studying PTSD and for clinical interventions in this patient population.


 July 15, 2012


Commentary by P. Read Montegue

"The Scylla and Charybdis of neuroeconomic approaches to psychopathology"

In this commentary directed at the contents of this special issue of Biological Psychiatry, the author discusses the application of neuroeconomics to understanding psychiatric disorders. He lays out important criteria for the approach and reviews the ways in which papers in this issue address the use of neuroeconomics; connecting neurocircuitry with psychopathology, studying social interaction, and utilizing neuroeconomics to gain insights into defined disorders. The commentary further discussed potential challenges facing the field in further applying these techniques to the understanding and treatment of psychiatric disorders.


Commentary by Cameron S. Carter

"Neuroeconomics: Sharpened tools of value for clinical cognitive and affective neuroscience"

The commentary discusses the application of neuroeconomics to studying the cognitive and neural underpinnings of psychopathology. Dr. Carter reviews the paradigmatic components of neuroeconomics and concludes that the approach may be best considered to be a rapidly developing area within cognitive, affective, and social neuroscience. The commentary further described ways in which this approach has contributed to conceptualizing psychiatric disorders and suggests ways to optimize the application of neuroeconomics to psychiatry in the future.


Commentary by Monique Ernst

"The usefulness of neuroeconomics for the study of depression across adolescence into adulthood"

This commentary focuses on the utility of pairing prospect theory with prediction error theory to study neural changes that reflect valuation processes. Dr. Ernst notes that depression in particular, involves changes in patterns of valuation and choice that appear to implement networks involved in emotional expression and regulation, motivation and elements of executive function. Further, changes in these networks with maturation may be related to the onset and development of mood symptoms in adolescence and through adulthood. Future experimental approaches building on current findings are discussed in some detail.


August 1, 2012


Commentary by Eric J. Nestler and John H. Krystal

"Planning the new national institute on substance use and addiction disorders"

The commentary discusses the recent decision by the National Institutes of Health (NIH) to consolidate addiction research into a new institute, the National Institute on Substance Use and Addiction Disorders (NISUAD). This change would involve the incorporation of the National Institutes on Drug Abuse (NIDA) and Alcohol Abuse and Alcoholism (NIAAA) into the NISUAD, as well as the potential adoption of other addiction related research from institutes across the NIH. Drs. Nestler and Krystal discuss the potential benefits of these changes, as well as the potential risks to the already under-funded study of addictive disorders.


Commentary by Enrico Brunetti and Fabio Malavasi

Feldman R, Zagoory-Sharon O, Weisman O, et al (2012). Sensitive Parenting Is Associated with Plasma Oxytocin and Polymorphisms in the OXTR and CD38 Genes. Biol Psychiatry 72:175-181.

A broad range of studies have implicated oxytocin (OT) in maternal behaviors. More recently variations in the OT receptor (OXTR) have also been implicated in social interactions, as has the CD38 ectoenzyme that has been found to mediate the release of OT in the brain. Furthermore, OXTR and CD38 risk alleles for autism spectrum disorders have been associated with deficits in social behaviors. In this paper, Dr. Feldman and colleagues examined a group of parents with four to six month-old infants. They report their findings that OXTR and CD38 risk alleles were associated with lower plasma levels of OT; and that both the presence of risk alleles and lower levels of OT were associated with less parental touch. In contrast, the combination of low-risk alleles and higher OT was associated with increased gaze synchrony between parents and off-spring. In addition, they found that individuals who reported having received greater parental care in childhood had higher levels of plasma OT in the present, and were more likely to possess lower-risk CD38 alleles-as well as to demonstrate greater infant touch. In the commentary, Drs. Brunette and Malavasi summarize current thoughts around the role of OT pathways in psychiatric disorders, including the many remaining unknowns.


Commentary by Anissa Abi-Dargham

Love TM, Enoch MA, Hodgkinson CA, et al (2012). Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner. Biol Psychiatry 72: 198-206.

In this study, Dr. Love and colleagues report on their finding an association between genetic variation within the oxytocin gene (OXT) and dopamine release in response to stress. They found that specific alleles in a group of healthy women correlated with increased dopamine release after a pain-stress stimulus, in a portion of the right ventromedial caudate. These findings were sex-specific; no such correlation was observed in the men tested. In addition, specific genetic variations and dopamine release were associated with at least some behavioral findings in the women tested. Only an association between stress-induced dopamine release and trait anxiety was seen in men. In the commentary, these findings are placed in the larger context of recent oxytocin research. Limitations of this study are discussed, as are potential follow-up studies.


Commentary by Detlef H. Heck and Lu Lu

Kaphzan H, Hernandez P, Jung JI, et al (2012). Reversal of Impaired Hippocampal Long-Term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors. Biol Psychiatry 72: 182-190.

Angelman syndrome (AS) is an autism spectrum disorder most commonly caused by chromosome 15 deletions encompassing the UBE3A gene. The authors have previously created a mouse model of AS which shares many features of the syndrome. The UBE3A gene has also been linked to schizophrenia, which includes some clinical elements in common with AS. In this study, Dr. Kaphzan and colleagues extended previous observations of alterations in the NRG1-ErbB4 pathway in patients with schizophrenia by measuring expression of neuregulin 1 and ErbB4 receptors in their AS model mice. They found evidence of increased neuregulin-ErbB4 signaling in the hippocampus of these mice; and further noted that ErbB4 inhibitors could both reverse changes in long-term potentiation, and enhance long-term contextual fear memory in the AS model mice. In the commentary, Drs. Heck and Lu note that these findings suggest a common deficit in synaptic communication across disparate psychiatric disorders. They expand on these findings by noting evidence for relationships between some of the genes involved. The commentary further elaborates on the support provided both for suggestions that synaptic changes may be a critical component of normal learning, and that related pathology might play a role in psychiatric illness.



August 15, 2012


Commentary by Mark A. Smith and Sanjeev Pathak

"The promise of rapidly acting antidepressants: Challenges and Opportunities"

The commentary addresses the recent increased interest in rapidly acting antidepressants, sparked by findings that ketamine infusion appears to be associated with rapid antidepressant response. Drs. Smith and Pathak discuss measurement parameters that need to be considered in evaluation prospective agents, as well as the lack of data with regard to longer-term treatment. Directions for future research are explored.


Commentary by Cortney A. Turner, Stanley J. Watson, and Huda Akil

Elsayed M, Banasr M, Duric V, et al (2012). Antidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depression. Biol Psychiatry 72: 258-265.

Fibroblast growth factor-2 (FGF-2) has been found to both respond to anxiety and depression in rodent stress models, and to mediate the effects of antidepressant and anxiolytic interventions. In this paper, previous findings were extended by exposing groups of rodents to chronic, unpredictable stress (CUS) paradigms. The authors found chronic FGF-2 intracerebroventricular infusions blocked some effects of CUS exposure. Further, the mitigating influence of antidepressants on the effects of CUS was vitiated by an inhibitor of FGF-2 receptor signaling. The authors also found that FGF-2 demonstrated direct antidepressant and anxiolytic action when infused into the prefrontal cortex. In the commentary, these findings are placed in the larger context of recent FGF-2 findings, and future research directions are explored.


Commentary by Mounira Banasr and Ronald S. Duman

Koehl M, van der Veen R, Gonzales D, et al (2012). Interplay of maternal care and genetic influences in programming adult hippocampal neurogenesis. Biol Psychiatry 72: 282-289.

In this paper, the authors strove to disentangle the effects of maternal behavior from genetic influences on hippocampal neurogenesis. Inbred mice were fostered by unrelated mothers from mouse strains known to exhibit differing pup-oriented behavior. Dr. Koehl and colleagues found that maternal environment impacted features of newborn granule cells in the dentate gyrus of the hippocampus only in the more genetically vulnerable mouse strain. The commentary describes the study at length, and notes congruent and disparate findings from other recent studies by this group and others. Drs. Banasr and Duman further describe the further questions now raised by these findings.


September 1, 2012


Commentary by Marco Koch and Tamas L. Horvath

Davis JF, Schurdak JD, Magrisso IJ, et al (2012). Gastric bypass surgery attenuates ethanol consumption in ethanol-preferring rats. Biol Psychiatry 72: 354-360.

Recent studies have suggested that in addition to promoting weight loss, Roux-en-Y gastric bypass (RYGB) surgery may decrease some reward-related behaviors. In this paper, the investigators used a review of human patients coupled with a pre-clinical study in rats to investigate the impact of RYGB on ethanol consumption. Dr. Davis and colleagues observed that ethanol consumption declined over an average of ~190 weeks in post-operative patients who reported frequent pre-operative consumption. In rats, the RYGB was similarly associated with decreased ethanol intake, and these effects correlated with ethanol-induced increases in glucagon-like peptide-1 (GLP-1), an anorexigenic gut hormone. Further, administration of GLP-1 agonists decreased ethanol consumption in those rats who did not receive the RYGB procedure, while the orexigenic gut hormone ghrelin inhibited the effects of the RYGB on ethanol intake.


Perelló M, Zigman JM (2012). The role of ghrelin in reward-based eating. Biol Psychiatry 72: 347-353.

In this review article, Drs. Perelló and Zigman discuss recent research into the orexigenic hormone, ghrelin. In addition to its effects on body weight homeostasis, ghrelin has been found to be involved in aspects of appetite and eating, as well as related reward circuitry. Further, they note links between the actions of ghrelin and eating-related stress-induced behaviors. The commentary, uses these two papers as the basis for a wide-ranging discussion of the roles of GLP-1 and ghrelin on energy use; alcohol consumption; and more expansively, reward-based behaviors.


Commentary by Aude Belin-Rauscent, Barry J. Everitt, and David Belin

Corbit LH, Nie H, Janak PH (2012). Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum. Biol Psychiatry 72: 389-395.

In this paper, the authors sought to examine the period of time over which use of alcohol switched from a pattern of use that is reliant on outcome, to habitual usage in groups of male Long-Evans rats. They found that while devaluation of ethanol by prior exposure resulted in fewer button presses early in the process of operant training, after eight weeks devaluation no longer resulted in significantly less response. Early in this process, inactivation of the dorsomedial striatum (DMS) attenuated ethanol seeking while inactivation of the dorsolateral striatum (DLS) had no effect. Later however, when rats had become desensitized to ethanol devaluation, this pattern was reversed-ethanol seeking was affected by inactivation of the DLS but not the DMS, suggesting disparate roles for these complementary striatal pathways. The commentary lays out more of the background for this study and summarizes the results in a particularly lucid manner. In addition, some possible physiological underpinnings for these findings are discussed.


Commentary by Charles P. O'Brien

Loland CJ, Mereu M, Okunola OM, et al (2012). R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biol Psychiatry 72: 405-413.

In this paper, Dr. Loland and colleagues report that both enantiomers of modafinil bind to the dopamine transporter (DAT) and inhibit dopamine uptake, albeit less strongly than does cocaine; they found that R-modafinil was more potent than S-modafinil. Nonetheless administration of both R- and S-modafinil was associated with increased extracellular dopamine concentrations in the nucleus accumbens. Disparate effects of substituting different strains of DAT mutant mice for wild-type suggest differences in binding sites between the enantiomers. In his commentary, Dr. O'Brien discusses potential clinical implications of these findings.


September 15, 2012


Commentary by Marion Joëls and E. Ronald de Kloet

Bagot RC, Tse YC, Nguyen HB, et al (2012). Maternal care influences hippocampal N-methyl-d-aspartate receptor function and dynamic regulation by corticosterone in adulthood. Biol Psychiatry 72: 491-498.

Previous research has demonstrated wide spread effects of maternal care on hippocampal function in rodents, including effects on the N-methyl-d-aspartate (NMDA) receptor. In this paper, the authors describe the effects of early grooming on NMDA receptor function and expression in adult rats, as well as grooming-related differences in long-term potentiation (LTP). In contrast with studies suggesting that NMDA receptor activity might be decreased with less maternal attention, Dr. Bagot and colleagues found that NMDA receptor expression and function was enhanced in rats who had received less grooming (LG) as pups. These findings were coupled with evidence of decreased LTP. Corticosterone administration raised NMDA receptor activity only in rats who had received more grooming (HG). The authors test their suggestion that this increased NMDA receptor activity in LG rats might be related to decreased LTP in this group-administration of a partial NMDA receptor antagonist did improve LTP in LG rats while impairing LTP in those rats who had received more grooming as pups. In the commentary, these findings are discussed in detail and placed in the context of previous studies of environment-related neuronal plasticity.


Commentary by Neill Epperson and Tracy L. Bale

Bath KG, Chuang J, Spencer-Segal JL, et al (2012). Variant Brain-Derived Neurotrophic Factor (Valine66Methionine) Polymorphism Contributes to Developmental and Estrous Stage-Specific Expression of Anxiety-Like Behavior in Female Mice. Biol Psychiatry 72: 499-504.

Sex differences in mood and anxiety disorders have been well established. In particular, connections have been widely observed between mood and anxiety symptoms, and life-cycle events associated with hormonal changes in women (e.g. menstrual, post-partum, and peri-menopausal periods). In this paper, Dr. Bath and colleagues use a "knock-in" mouse model in which the human brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism (SNP) was inserted into the BDNF gene, to test the interaction of BDNF changes with hormonal fluctuations. As previously observed, mice with the SNP showed increased anxiety-like behaviors; in addition, these mice exhibited greater anxiety than wild-type mice during the estrous phase, and greater correlation of anxiety-like behaviors with age. While the commentary counsels caution in generalizing these results to human patients, the potential clinical implications of these findings are discussed at length.


Members of SOBP receive Biological Psychiatry as part of their membership     Click here to learn more about this prestigious journal.


Top 6 Reasons to Publish in Biological Psychiatry  
1.  High Impact Factor - 8.674
2.  4th of 126 Psychiatry Journals
3.  15th of 237 Neuroscience Journals
4.  1st Decision - 30 Days
5.  ePubs - 6 Weeks
6.  In Print - 4 Months
Welcome New Members
Please welcome the following new members to the Society, effective October 1, 2012:  
Joanna Bakas Georgelas   
Ian Cook
Dept. of Human Services - Tasmania
UCLA Semel Institute for Neuroscience & Human Behavior
Walter DoegePrivate Practice  
Sobia HaqqiZiauddin Medical University
Kenji HashimotoChiba University
Jared MoreinesUniversity of Pittsburgh School of Medicine
Lisa PanUniversity of Pittsburgh
Mohamed SherifSUNY Downstate Medical Center
Sarah ShortUniversity of North Carolina - Chapel Hill
Thomas WeickertUniversity of New South Wales
If you are interested in joining the Society please visit or email  We will be happy to answer any questions you may have regarding the Society or find a sponsor for your application. 
Other Meetings of Interest

XXth World Congress of Psychiatric Genetics: Confronting the Complexity of Brain and Behavior 

October 14-18, 2012

Hamburg, Germany


A Joint Congress of Psychiatry 

November 29 - December 2, 2012

Athens, Greece

  • World Psychiatric Association Thematic Conference on Intersectional Collaboration: The Multidisciplinary Facets of Psychiatry
  • Fourth European Congress of the International Neuropsychiatric Association: Overlap and Integration in Neuropsychiatry
  • First Interdisciplinary Congress on Psychiatry and Related Sciences

ACNP Annual Meeting 

December 2-6, 2012
The Westin Diplomat

Hollywood, Florida


June 23-27, 2013
Kyoto, Japan

February 27 - March 2, 2013
The Hyatt Regency
Bethesda, MD


April 6-9, 2013
Nice, France

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Visit SOBP's Career Center  today to explore employment opportunities.  Post an anonymous resume for employers or recruiters to view.
Links to other resources are available for your convenience.
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Society of Biological Psychiatry Business Office
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Society of Biological Psychiatry Newsletter Editorial Staff 

Stephen M. Strakowski, MD, Editor

Editorial Board
Helen Mayberg, MD
William B. Lawson, MD, PhD, DLFAPA 
Alan H. Young, MD, PhD
Caleb M. Adler, MD
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