The Agnes Flanagan Chapel is one of the first buildings that visitors to Lewis & Clark College see as they drive up Palatine Hill Road and approach the main campus. The chapel is named in honor and memory of college trustee Agnes Flanagan whose vision, enthusiasm and generosity made its construction possible. Completed in the fall of 1968, the chapel was officially dedicated in February of 1969.

The chapel's impressive contemporary lines and distinctive conical shape incorporate a strong Northwest Coast Native American influence, and are the design of architect Paul Thiry. The Wallace Howe Lee Memorial Bridge, leading from the roadway to the chapel entrance, is flanked by sculpted figures of the four evangelists (Matthew, Mark, Luke and John). Chief Lelooska of the Cherokee tribe designed these figures which combine ancient Christian symbolism with the symbolism of the Northwest Coast Native American people.

The beautiful interior of the chapel features a magnificent Casavant organ.