NanoImaging Services specializes in nanoparticle characterization using transmission electron microscopy. We focus on soft biological materials including antibodies, liposomes, VLPs, viruses and other proteins that are used for vaccines, drug delivery and therapeutics for the Pharmaceutical and Biotechnology industries. Our technology is uniquely capable of distinguishing morphology on a particle by particle basis.

 

  



NanoImaging Services can provide high magnification images of antibody and antibody complexes.  The technique uses specialized negative stain and automated TEM methods to acquire thousands of images of the individual particles.  The particle images are then computationally aligned and sorted into unique classes. Above is an example of a set of 2D class averages computed from images of an antiErbB2 mAb.

 

 

Recent academic papers that have used similar techniques include:

 

Pejchal R, et al., A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science. 2011;334(6059):1097-103.

 

McLellan JS, et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 2011;480(7377):336-43.

 

Westfield GH, et al., Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A. 2011;108(38):16086-91.

 

 
 

NanoImaging Services will be attending the following upcoming meetings.  We would welcome the chance to meet with you.

 

 March 17-20 ABRF Annual Meeting, Orlando, FL

Anke Mulder, Director of Research and Development, will give a talk on "Cryo Transmission Electron Microscopy as an orthogonal tool for characterization of biopharmaceuticals"

 

 March 25-29 Spring American Chemical Society Meeting, San Diego, CA

NanoImaging Services will be exhibiting at booth number 208.



May 20-25 Vaccine Technology IV, Albufeira, Portugal

NanoImaging Services will participate in the meeting

 

May 21-23 AAPS Biotech, San Diego, CA

NanoImaging Services will be exhibiting at booth number 208. 
 

July 15-18, Controlled Release Society Annual Meeting, Quebec City, Canada

NanoImaging Services will be exhibiting at booth number 407.

 

 

Contact Information:
 
NanoImaging Services 
11099 North Torrey Pines Rd., #250 
San Diego, CA 92037 
Ph: 888-675-8261 

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