Featured Article
Where Can Big Pharma Turn When You Need To "Just Look At The Thing"?
There are times when a picture conveys far more than the proverbial thousand words. For the R&D efforts of the pharmaceutical industry it can mean the difference between confusing data and statistically valid evidence, which translates directly to saved time and dollars on the bottom line. Such is the case for pharmaceutical process development or formulation functions requiring biomolecule characterization. Clear visual evidence of morphology, size, shape, and 3D structure, speak volumes to researchers and regulators. So where can the pharmaceutical industry turn when they just want to look at the thing? The answer is the commercial cryoTEM service provider, NanoImaging Services, who routinely provide transmission electron microscopy (TEM) characterization services to directly visualize nanoscale biomolecules such as liposomes, virus like particles, or protein complexes, in their native hydrated state. Learn more...
|
|
| Greetings!
Welcome to the spring issue of NanoImaging Services Inc. quarterly newsletter. NanoImaging Services is exclusively focused on reliable, accurate nanoparticle characterization methods for the pharmaceutical and biotechnology industry. Take a minute to see how NanoImaging Services can help your research. |
|
Accurate Nanoparticle Characterization in Drug Delivery
The development of nanoparticles as drug delivery vehicles is one of the fastest growing sectors of the biopharmaceutical industry. Nanoparticles being developed for drug delivery, including liposomes, dendrimers, and colloids, are complex structures and often polydisperse. There is considerable evidence that the physical properties of nanoparticles are tightly linked to their functional behavior and may thus be a determining factor in the biodistribution, safety, and efficacy of the pharmaceutical product. The physical characterization of the product includes properties such as the size, shape, morphology (e.g., lamellarity, crystallinity, porosity, surface roughness), and aggregation state of the particles. Furthermore, these properties are often dependent on the specific environment of the particles and thus should ideally be assessed in the native form of the pharmaceutical. Learn more ...
NanoImaging Services provides a unique method of nanoparticle characterization, employing cryoTEM and specialized sample prep to visualize the native morphology of nanoparticles in a fully hydrated state. Characterization services include a detailed analysis report, rapid turnaround times, and direct secure online access to archival imaging data to ensure timely and distributed access to results. To learn more about this and other services provided by NanoImaging Services visit http://www.nanoimagingservices.com |
|
NanoImaging Services' Founders Contribute to Research and Development of Nanoparticles for Biomedical Applications
Clint Potter and Bridget Carragher, founders of NanoImaging Services, also have dual careers as academic researchers at the Scripps Research Institute, La Jolla , California, where they direct the National Resource for Automated Molecular Microscopy (NRAMM). In this role they have recently contributed to several projects related to the design of nanoparticles for biomedical applications:
"Copolypeptide-Stabilized Double Nanoemulsions as Innovative Drug Delivery Platforms"
The Deming lab at UCLA is working in the field of self-assembling polypeptides for potential applications in medicine. Samples analyzed at the National Resource for Automated Molecular Microscopy, included oil emulsions stabilized by polypeptides. These are remarkable samples in that they spontaneously form double emulsions (a droplet of water inside a droplet of oil dispersed in a water phase), something that has not been seen with any other type of surfactant. Learn more...
"New Highly Transfecting Hexagonal Phases for Gene Delivery"
Newly designed multivalent lipids have been synthesized and investigated as DNA delivery vectors. The Safinya lab, University of California at Santa Barbara, has discovered new vesicle phases formed in mixtures of novel lipids, phospho-lipids and water. Structural studies of this phase were carried out using differential contrast microscopy (DIC) and cryo transmission electron microscopy cryo-TEM. Learn more... "DNA 3D Molecular Cages" The laboratory of Hao Yan, Arizona State University, aims to tackle a grand challenge in nanotechnology, which is to engineer three-dimensional (3D) nanostructures. The goal is to develop self-assembling 3D DNA nanoscaffolds to organize nanoparticles (NPs) into rationally designed, spatially addressable 3D architectures, with long-term prospects in nanophotonics, nanoelectronics and biological/chemical sensing. By attaching single strands of DNA to gold nanoparticles, the Yan lab has created DNA nanotubes in a variety of architectures that may lead to innovations in biomedical design. Learn more... |
|
|
New and High Volume Customer Discounts!
Thinking about how NanoImaging Services can help your research? For starters, your first imaging project can take advantage of a one time introductory discount available only to new customers. Substantial discounts are also available for high volume and repeat customers. Contact us at info@nanoimagingservices.com or call toll free 888.675.8261 to learn more about NanoImaging Services capabilities. |
|
|
