News from Chronic Illness Recovery

Patient News

Annual Patient Workshop

Save the date:

Sunday

February 17, 2013

Hilton Dallas-Fort Worth Lakes Executive Conference Center

Therapy Tip

Identification of specific pathogens isn't necessary to begin Inflammation Therapy. Trying to pinpoint a specific organism and testing for antibodies is futile and unnecessary because bacteria living within the monocytes and macrophages can't be detected by routine lab tests.

Recovery Reports

We are contacted daily by people with chronic illnesses who are looking for an effective treatment. Many ask us to provide evidence of efficacy in the form of statistics or stories. If you have recovered your health or had significant symptom improvement with Inflammation Therapy (or a similar treatment), please help us 'pay it forward' by telling your story. We will post it in the public section of our website to encourage others. Any report, short or long, with or without objective data (e.g., lab results, imaging reports) would be helpful. Please

send your story to

our email .

Thank you!

To see the latest recovery reports,

click here.

CIR Library Access

Access to our free, extensive, easy-to-read Library of Information

(see this sample page)

and Physicians' Reference Library is available to anyone, without enrollment in our counseling program. If you're interested in using this resource, please send a request to our email

address along with your doctor's name and fax number (in the US or Canada) or his/her email address, so we can notify your doctor that you have access to this information.

A list of the articles in our libraries is available at this link.

Physicians may use CIR libraries even if they don't have a patient enrolled in our counseling program. Interested medical practitioners should contact CIR and ask to register.

Survey

Volunteers who have a diagnosis of autoimmune or inflammatory disease or are chronically ill but who are not being treated with Inflammation Therapy, the Marshall Protocol or the Stillpoint Protocol are needed to be in the control group of our clinical study. If you meet these criteria and would like to take part in this project (which will only take a few minutes

each month), please

email address.

"Thanks for the effort to track (data via survey),

it will be the underpinnings of this treatment at some time." ~James Graves

CIR is an IRS-recognized 501(c)3 non-profit charitable organization.

Donate to CIR

in support of our educational and research efforts.

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Contact Us

email address here

you may phone us toll free from anywhere in the US and Canada

1-888-846-2474

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Chronic.Illness.Recovery

Have you enjoyed this newsletter?

We are happy to report that our website has been extended with HONcode another year. The HONcode certification is an ethical standard aimed at offering quality health information.

Issue: 32

June 2012

Greetings!

We're very proud to be celebrating the three year anniversary of our website/forum. It's exciting to look back and realize all that we've accomplished in such a short time.

Our incredibly talented staff deserves a big round of applause for their dedication and devotion to our mission of informing medical practitioners about Inflammation Therapy.

We hope you've had a chance to be instrumental in our efforts to inform physicians about this effective treatment. It's easy to do - just enroll in our counseling program. You get the benefit of professional counseling and your doctor learns how to manage Inflammation Therapy. You'll be helping to increase awareness of treatment efficacy which may spark an interest in the research community so the resources to conduct clinical studies will become available.

Warm regards,

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About Inflammation Therapy

How to Diagnose Dysregulated Vitamin D Metabolism

Chronic inflammatory diseases develop in reaction to the invasion of nucleated cells by pleomorphic bacteria (L-forms). The intracellular bacterial processes disable a crucial part of the innate immune system, the VDR (Vitamin D Receptor), which results in dysregulated vitamin D metabolism.

Dysregulated vitamin D metabolism is diagnosed by measuring the D-metabolites: 25 hydroxyvitamin-D (25-D) and 1,25 dihydroxyvitamin-D (1,25-D).

It's essential to measure both 25-D and 1,25-D because the level of 25-D doesn't directly reflect the level of 1,25-D. The key vitamin D level is 1,25-D because it is the active metabolite.

Current 25-D lab ranges have been skewed high by dietary supplementation and flawed thinking in response to epidemiological studies showing low levels of 25-D in many chronic diseases. This represents a failure to recognize that low 25-D is caused by the disease process.

The Merck Manual (Oct 2006) states that in healthy persons, the 25-D level is 25 to 40 ng/mL.

Patients with dysregulated vitamin D metabolism (who have not been supplementing with vitamin D) often have a low level of 25-D.

Many labs list inappropriately high ranges for 1,25-D; current ranges are skewed high because a large percentage of patients getting this unusual test are ill with undiagnosed Th1/Th17 inflammation. Therefore, a 1,25-D result that is within current normal lab ranges may still indicate dysregulated vitamin D metabolism.

The Merck Manual (Oct 2006) states that in healthy persons 1,25-D levels are 20 to 45 pg/mL. A large Danish study found that the mean value for 1,25-D in a normal population was 29 pg/ml with a standard deviation of 9.5.

The 1,25-D measurement is a sensitive assay and results can be falsely low if the sample isn't handled correctly. High values of 1,25-D, however, are always reliable and diagnostic of dysregulated vitamin D metabolism.

Elevated 1,25-D (hypervitaminosis-D) can have many negative consequences. For example, at levels above about 42 pg/mL 1,25-D begins to stimulate bone osteoclasts, causing bone to be resorbed (dissolved) back into the bloodstream. Not only does this lead to osteoporosis, but also to calcium being deposited into soft tissues of the body; including lungs, breasts and kidneys (where it may form kidney stones). See this study: Vitamin D Antagonist, TEI-9647, Inhibits Osteoclast Formation Induced by 1alpha,25-dihydroxyvitamin D3 from Pagetic Bone Marrow Cells.

Patients on Inflammation Therapy (IT) take Benicar (olmesartan medoxomil) to up-regulate the VDR so anti-microbial peptides are produced which kill the intracellular bacteria and restore normal vitamin D metabolism. This is evidenced by the eventual reduction in serum 1,25-D to normal levels and resolution of inflammatory symptoms.

Scientific Articles

Hiding from the World - Scientists Sequence the Elusive Whipple Genome "Most microbes on the planet cannot be cultivated and are therefore difficult to study."

Dr. Wilmore Webley on Chlamydia Pneumonia & Biofilms

A video interview with a University of Massachusetts, Amherst biofilm expert who explains how polymicrobial species cause chronic health issues by evading the immune system, resulting in chronicity.

Antibiotic Penetration of and Bactericidal Activity Within Endothelial Cells The concept of intracellular organisms may be protected from the host's immune response was first proposed by Ross and Jones in 1916.

Mysteries of the Bacterial L-Form: Can Some of Them Be Unveiled?
"L-forms were discovered in 1935 by Emmy Klieneberger and subsequently described by many authors. Much interest in L-forms arose from their assumed but still unconfirmed roles as concealed pathogens and as survivors of antibiotic action. Yet, as justly deplored in a recent review, L-forms are still "unfamiliar to many microbiologists" and are often regarded "with skepticism." One hears complaints about the unusually labor-intensive and time-consuming process of L-form isolation and cultivation, and the uncertain outcome. However, in my experience, this can be overcome by patient determination."

Invasion of the Central Nervous System by Intracellular Bacteria

"Infection of the central nervous system (CNS) is a severe and frequently fatal event during the course of many diseases caused by microbes with predominantly intracellular life cycles."

Breakthrough in Tracking a Cause of Chronic Infections

Northeastern University researchers have identified a protein that enables bacterial cells to survive antibiotic treatment. This discovery by biology professor Kim Lewis and his team, published in the February 22, 2010 issue of the journal PloS Biology, reveals for the first time the mechanism by which bacteria maintain a chronic infection in spite of aggressive therapy with antibiotics.

About CIR

How do I enroll in your counseling program?

To enroll in the Chronic Illness Recovery counseling program, send us an email and ask for an Enrollment Form. You will be asked for your doctor's email address or fax number so we send him/her a letter of explanation about the CIR counseling program and the professional forms to sign. When we've received all the necessary documents, any applicable fee and reviewed the enrollment form, you'll be notified of acceptance and registered at the Website/Forum where you will post progress reports and ask questions.

How long does this process take?

The enrollment process can be accomplished very quickly - it all depends on the length of time it takes for the four necessary documents to be returned (and any applicable fee to be made). Some patients and doctors return the forms the same day they're received and others need more time to accomplish this task.

Should I wait to enroll before starting Inflammation Therapy?

Because it's important to get off to a good start we recommend completing the enrollment process before starting therapy so that you can ask questions about the medications and we can determine that you understand the process. Then if you have problems initially you'll be able to turn to the CIR Nurses for help.

Quotes

"Thanks so much for your steady guidance...I would really be lost without your insights into the program." Pat

"The most significant change during the last few months has been cognitive ~ improvement in my ability to think clearly and retain recently learned information (especially info gathered from reading). The mental fogginess lifts considerably for extended amounts of time. It's reassuring to know that my previous capabilities (reading, writing, arithmetic, etc...) are still possible... sort of like discovering there has been no permanent damage to the information super-highway in my brain." Cindra