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Annual Patient Workshop
Save the date:
Sunday
February 17, 2013
Hilton Dallas-Fort Worth Lakes Executive Conference Center | |
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Therapy Tip
It's essential to measure both 25-D and 1,25-D to rule out a vitamin D deficiency and diagnose vitamin D dysregulation. The level of 25-D doesn't directly reflect the level of 1,25-D. Patients with Th1/Th17 inflammation (who have not been supplementing with vitamin D) often have a low level of 25-D while the level of 1,25-D is elevated. Testing only 25-D, as is usually done, may result in a false diagnosis of vitamin D deficiency. The key result is the level of 1,25-D because it is the vitamin D metabolite that affects biologic function. | |
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Recovery Reports
We are contacted daily by people with chronic illnesses who are looking for an effective treatment. Many ask us to provide evidence of efficacy in the form of statistics or stories. If you have recovered your health or had significant symptom improvement with Inflammation Therapy (or a similar treatment), please help us 'pay it forward' by telling your story. We will post it in the public section of our website to encourage others. Any report, short or long, with or without objective data (e.g., lab results, imaging reports) would be helpful. Please
send your story to
our email .
Thank you!
To see the latest recovery reports,
click here. | |
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CIR Library Access
Access to our free, extensive, easy-to-read Library of Information
(see this sample page)
and Physicians' Reference Library is available to anyone, without enrollment in our counseling program. If you're interested in using this resource, please send a request to our email
address along with your doctor's name and fax number (in the US or Canada) or his/her email address, so we can notify your doctor that you have access to this information.
A list of the articles in our libraries is available at this link.
Physicians may use CIR libraries even if they don't have a patient enrolled in our counseling program. Interested medical practitioners should contact CIR and ask to register. | |
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Survey
Volunteers who have a diagnosis of autoimmune or inflammatory disease or are chronically ill but who are not being treated with Inflammation Therapy, the Marshall Protocol or the Stillpoint Protocol are needed to be in the control group of our clinical study. If you meet these criteria and would like to take part in this project (which will only take a few minutes
each month), please
contact us at our
email address.
"Thanks for the effort to track (data via survey),
it will be the underpinnings of this treatment at some time." ~James Graves | |
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CIR is an IRS-recognized 501(c)3 non-profit charitable organization.
Donate to CIR
in support of our educational and research efforts.
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Contact Us | |
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you may phone us toll free from anywhere in the US and Canada
1-888-846-2474
Skype
Chronic.Illness.Recovery
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Have you enjoyed this newsletter?
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We are happy to report that our website has been extended with HONcode another year. The HONcode certification is an ethical standard aimed at offering quality health information. | |
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Greetings!
Many of you are gearing up for the challenges of light and heat avoidance that the summer season brings. At the same time, our friends on the other side of the world are breathing a sigh of relief that Fall and cooler temperatures have arrived.
Wherever you are in the world, we're delighted you're part of our growing community. You may be an enrolled patient, a library subscriber, one of our donors or an interested observer.
Whatever your role, we're grateful for your participation and hope you will continue to spread the word that CIR is helping medical practitioners understand the management of Inflammation Therapy by counseling their patients.
Cheerful regards,
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About Inflammation Therapy |
The role of vitamin D
The vitamin D axis includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP, also known as Gc-globulin).
25-hydroxyvitamin-D (25-D) is escorted into cells where it's converted into 1,25-dihydroxyvitamin-D (1,25-D), the active vitamin D metabolite.
1,25-D has many important functions. It circulates as a hormone in the blood to maintain normal blood levels of calcium and phosphorus, which promotes the healthy growth and remodeling of bone.
1,25-D has other essential purposes, such as the proliferation, differentiation and apoptosis of cells. It also modulates the immune system and down-regulates the renin-angiotensin system (RAS).
1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.
The majority of circulating vitamin D is bound to the VDBP which has immunomodulatory functions and acts as a scavenger protein to clear extracellular debris released from necrotic cells.
VDBP is the precursor of GcMAF (group-specific component macrophage activating factor). GcMAF (the Gc protein is also known as the VDR) is a powerful molecule for immune activation.
Normally, production of 1,25-D is tightly controlled by the kidneys in response to a complex system of hormonal regulation. But if nucleated cells are infected with bacterial pathogens, 1,25-D is generated by the inflammatory response.
This study states "It has been demonstrated that macrophages can produce 1α,25(OH)2D3 on activation with interferon γ (IFN-γ), although little is understood about the biologic significance of this response."
1,25-Dihydroxyvitamin D3 is a potent suppressor of inteferon mediated macrophage activation.
Elevations in 1,25-D are created by the immune system (activated macrophages) in an attempt to activate the VDR in order to transcribe anti-microbial peptides to eliminate L-form bacteria. However, the VDR is blocked by proteins secreted by these intracellular bacteria as a strategy to avoid destruction. This causes the level of 1,25-D to exceed the upper limit normally controlled by the kidneys. The result is dysregulated vitamin D metabolism and persistent chronic inflammation.
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About CIR | |
A steadily increasing number of medical practitioners are using Inflammation Therapy (IT) to treat chronic illness.
Because this unique medical regime causes a temporary exacerbation of symptoms which can be intolerable, physicians have been asking for help to understand the nuances of the recovery process and keep the expected immune system reactions under control.
Working with patients who are on Inflammation Therapy has been the most effective means of gaining an understanding of how to introduce and adjust the therapy medications to maintain tolerable symptoms and ensure patient safety. To that end, Chronic Illness Recovery has created a secure, private interactive Forum to provide a vehicle for RNs to counsel patients while working closely with their physicians.
Professional nurses, experienced with counseling patients on IT, monitor and advise patients through the recovery process while keeping their doctor informed each step of the way. Interested patients should send an email to ask for an Enrollment Form.
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Quotes | |
"I have been doing more and been feeling more like my old self and am enjoying life so much more and don't feel as disabled by the disease." Emmley
"My husband and I are going to take a break on our own for a couple of weeks, something we have not been able to do in years. It is good to feel that I can now cope with things and I am so grateful to Inflammation Therapy and all the advisers who have helped me get this far." Safeharbour
"...my IT doctor is most enthusiastic than ever about this IT protocol and the possibility for my recovery. With their support, your encouragement and the recovery stories I read, I am getting through the most difficult days."
Cindra
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