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From the Circle
A Newsletter from Chronic Illness Recovery

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What's New?
Quotable Quotes
Inflammation Therapy
Therapy Tip
Scientific Article
Educational Resources
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About Our Services

Who May Use Our Services

CIR's Unique Service

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Please Save the Date!

Sunday, Feb, 20, 2011
Our first-ever
Patient Workshop
in
Fort Worth - Dallas,
Texas

If you can arrange to be there, we would love to see you!

What's New?
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Access to our Library of Information with the details of therapy prescription management is available to patients, without enrollment in our counseling program, for a suggested annual donation of $25. Interested patients should send a request, along with their doctor's name and fax number or email address to: info@chronicillnessrecovery.org

Your doctor will be notified that you have access to this information. Click here for a list of articles available in our Library of Information and Physicians' Reference Library.
Physicians may use CIR libraries, even if they don't have a patient enrolled in our counseling program....simply contact us and ask to register. There is no fee for doctors.

 
Quotable Quotes
"You guys were right - lowering the dose of olmesartan has improved kidney function by far. Potassium is normal and Creatinine has dropped substantially." ~ Simon Shepherd

"Thank you for the information regarding my questions. It's great to have your advice, direction and assistance." ~ Deborah

"I am looking forward to starting the antibiotics and feel fairly confident. Perhaps because I have found an incredible amount of support in the pages of this forum." ~ Cindra

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Issue: 8    May 2010
Greetings! 

computer_friendsMay marks the end of a school year, and many will be putting education on hold for a few months. At CIR, we continue our focus on reaching out to physicians interested in learning about inflammation therapy (IT). Patients are asking their doctors to authorize their enrollment in CIR's counseling program in order to facilitate their understanding of this treatment. Their weekly reports and the Nurse responses are faxed to their physicians to inform them about managing IT and to ensure they agree with the advice given.

We're excited to report an extension of our educational services with a Physicians' Seminar to be held Feb. 18-19 at the Hilton Executive Conference Center near Dallas, Texas. A Patient Workshop will be held the following day.

Thanks to everyone who has informed their physician about CIR. We expect our efforts will result in a lower therapy failure rate and increase the likelihood that this effective treatment will be offered to more patients.

Cheers,
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About Inflammation Therapy
The importance of antibiotics and the correct Benicar dose

In the past couple of years, no new scientific research has come to light to change the understanding of how Benicar affects the immune system and how therapy antibiotics contribute to the recovery process. However, the CIR Health Team has discovered new medication adjustment strategies to manage Herxheimer reactions and increase the likelihood of  treatment effectiveness.

Benicar has two opposite actions, and for some patients, Benicar's ability to activate the VDR (immune system functions better>bacterial die-off>inflammation increased>Herxheimer reaction>increased symptoms) overrides its ability to stop activation of the Nuclear Factor-kappa-B cytokine pathway (anti-inflammatory) and dock into other receptors (e.g. opioid) to reduce pain and other symptoms.

Activating the VDR can occur at relatively low doses. If this action predominates, we have seen that a lower dose of Benicar reduces intolerable symptoms and resolves abnormal lab work. See Benicar Dosing to Prevent Organ Damage During Therapy.

Antibiotics play a key role during inflammation therapy. All of the antibiotics used with inflammation therapy can be anti-bacterial and immuno-modulatory at the same time, in differing degrees, based upon dose and individual physiology.

We're convinced VDR activation AND the weakening and removal of L-form bacteria with bacteriostatic antibiotics are essential to recovery. The immuno-modulation of the correct antibiotic dose can also be essential to ensure that Herxheimer actions are tolerable.

Each patient will react a little differently to different doses of antibiotics, probably depending on the bacterial species, bacterial load and the function of the immune system at that time. Individual response to treatment precludes a simplistic, one-size-fits-all model of inflammation therapy. Patients need guidance from experienced medical professionals to help them learn how to adjust therapy antibiotics as needed to maintain tolerable herxing and ensure a safe recovery. See The Importance of Antibiotics During Inflammation Therapy.
Therapy Tip
Anecdotal reports indicate the routine use of sublingual Benicar is safe and effective at activating the VDR and providing a palliative, anti- inflammatory effect. There is no evidence that Benicar cannot be taken sublingually on a long-term basis and patients with gastrointestinal symptoms may benefit by using this route for each dose.
New Research
Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial.   *

In a clinical study of elderly women given high dose vitamin D, participants in the high-dose vitamin D group had 26% more fractures and an increased risk of falls, compared to women in the placebo group. The study followed participants for 3-5 years.

The study authors wrote, "Our study used the largest total annual dose of vitamin D (500,000 IU) reported in any large randomized controlled trial, raising the possibility that the adverse outcome is dose-related."

They concluded, "the outcome of this study suggests that safety of high-dose vitamin D supplementation warrants further study."

PDF with full text from JAMA 2010 May 12;303(18):1815-22.

Related article: Vitamin D and Calcium: Systematic Review of Health Outcomes

*The link available by clicking-through the title above requires registration or log in with Medscape.
About Chronic Illness Recovery
Why have you felt it necessary to add educational resources at your site when they are available at the MP site?

CIR added educational resources to our CIRCLE website because the information on other websites is a lay-person revision of copyrighted material written by Meg Mangin R.N., P. Bear R.N. and Belinda Fenter. We recognized the need to provide accurate information, kept current by medical professionals. Our library is designed to provide easy access to our attractively-formatted and easily-understood articles.

Our Physicians' Reference Library is unique in that it contains documents written by physicians to help streamline the clinical management of inflammation therapy.

Over 50 of our library articles have recently been made available to the general public, to provide the same high quality information about the basics of inflammation therapy. You will find them at this link.