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Chuck Fulmer, R.Ph., FIACP 672 Lanier Park Dr.
Gainesville, GA 30501
770-536-CARE (2273)
Fax: 770-536-2635
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Pregnenolone: The "Parent Hormone"
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· Pregnenolone is the "parent hormone" from which neurosteroids and sex hormones are formed, and affects learning, memory, mood, sleep, and many other functions.
· Pregnenolone may relieve anxiety, help to fight depression, and reduce symptoms of withdrawal from nicotine and alcohol addiction.
· Pregnenolone and other neuroactive steroids can protect brain cells against the long-term damage that can lead to Alzheimer's disease and other forms of dementia.
· Hormone levels naturally decline with advancing age. People with lower pregnenolone levels are more likely to suffer from memory deficits, mood disorders, and even some mental illnesses.
The conversion of cholesterol to pregnenolone constitutes the first of many steps in making some of the body's key hormones, including dehydroepiandrosterone (DHEA), testosterone, progesterone, estrogen, and cortisol. Pregnenolone's active metabolites (breakdown products) fulfill a myriad of essential roles in the body, from stimulating memory to easing anxiety.
Pregnenolone has vast potential for maintaining healthy mental function and may be the most potent memory enhancer yet reported. Alzheimer's disease patients have lower levels of pregnenolone, allopregnanolone (a pregnenolone metabolite) and DHEA-sulfate (DHEAS) in all the main memory-related areas of their brains, compared with control patients. Furthermore, the brains of patients with the highest neurosteroid levels display the lowest collections of destructive amyloid-beta proteins. Researchers have also shown that pregnenolone increases brain levels of acetylcholine, a key neurotransmitter required for optimal brain function, which is deficient in patients with Alzheimer's disease.
Neurosteroids are known to affect anxiety in humans. Researchers from the University of California in San Francisco performed two studies of pregnenolone and anti-anxiety medications and concluded that pregnenolone, taken as a supplement while using an anti-anxiety medication, could reduce many adverse effects of the anti-anxiety medication, such as sedation and memory impairment. One study revealed that schizophrenic patients with the lowest levels of pregnenolone were also most likely to have high levels of anxiety. Pregnenolone and other neurosteroids have also been shown to counteract the anxiety-like behavior that is associated with nicotine or morphine withdrawal, and may offer relief to individuals seeking to overcome these addictions. |
Vitamin D
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Vitamin D deficiency has reached epidemic proportions. Common advice - which often includes taking cholesterol-lowering drugs (because cholesterol is needed to make vitamin D), avoiding the sun or always wearing sunscreen, and a low-cholesterol diet, combined with a recommended daily intake of vitamin D that is far below what researchers now believe to be sufficient - has led to widespread vitamin D deficiency.
Vitamin D is best known for its role in calcium metabolism and bone health, but new roles are continually being discovered for mental health, blood sugar regulation, maintenance of the immune system, and cancer prevention. At the 2006 annual meeting of the American Association for Cancer Research, a study was presented suggesting that adequate vitamin D early in life may be important to lower breast cancer risk in later years. Vitamin D deficiency is a known risk factor for cancer, type 1 and type 2 diabetes, and hypertension.
Recent evidence suggests that vitamin D intakes above current recommendations may be associated with better health outcomes. Researchers from the Department of Nutrition, Harvard School of Public Health, summarized evidence from studies that evaluated thresholds for serum vitamin D concentrations in relation to bone mineral density (BMD), lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer. They found that the most advantageous serum concentrations of vitamin D are between 90 and 100 nmol/L (36-40 ng/mL), and concluded: "... the amount of vitamin D required for optimal benefit may be much higher than would be provided by current recommendations (200-600 IU per day), especially in those with minimal sun exposure." In no less than 50% of the population, a daily intake for all adults of at least 1000 IU (25 micrograms) vitamin D-3 (cholecalciferol) is needed to achieve optimal vitamin D concentrations.
It is important to supplement with the active form, vitamin D-3 (cholecalciferol), which is more effective than vitamin D-2. Ask our professionals to recommend a quality Vitamin D supplement. |
As compounding pharmacists, we are
problem solvers. If you have friends with problems (hormones, chronic
pain, foot, nail, gynecologic, etc.) that are not being solved with
conventional therapy, forward this email to them for FREE confidential
consultations on their problems. If we can help, they will each
receive $15.00 off their first prescription and you will receive a
$15.00 credit on your next refill.
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Partners in Care, Inc.
Compounding Pharmacy
672 Lanier Park Dr.
Gainesville, GA 30501
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Bring us your medication problem, and if we can help, you will receive a
$15 CREDIT on your first new compounded prescription.
Print this email
and present at Partners in Care, and add the name of the friend who
referred you to receive this credit.
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Offer Expires: 06/30/09 Friend's Name _________________________________________________
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We offer private consultations in Pain Management and Bio-Identical Hormone Replacement Therapy. Please call to schedule an appointment.
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Order your prescription refills online 24 hours per day at http://picrx.com/refillrequest.htm! |
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