Every time we choose not to obey His Word, not to trust Him our heart becomes hardened or becomes like stone.   When ever we hold onto a hurt, resentment, anger, jeoulousy, pride and refuse to forgive, our heart becomes hardened.  Rejection of His Torah and Yeshua His Annointed brings hardness of heart.   Turning from His Ways, His Truth to go our own way brings hardness of heart.

 

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 Isa 63:7 I will recall the grace of Adonai and the praises of Adonai, because of all that Adonai has granted us and his great goodness toward the house of Isra'el, which he bestowed on them in keeping with his mercy, in keeping with the greatness of his grace.
Isa 63:8 For he said, "They are indeed my people, children who are not disloyal." So he became their Savior.
Isa 63:9 In all their troubles he was troubled; then the Angel of His Presence saved them; in his love and pity he redeemed them. He had lifted them up and carried them throughout the days of old.
Isa 63:10 However, they rebelled, they grieved his Holy Spirit; so he became their enemy and himself fought against them.
Isa 63:11 But then his people remembered the days of old, the days of Moshe: "Where is he who brought them up from the sea with the shepherds of his flock? Where is he who put his Holy Spirit right there among them,
Isa 63:12 who caused his glorious arm to go at Moshe's right hand? He divided the water ahead of them, to make himself an eternal name;
Isa 63:13 he led them through the deep like a sure-footed horse through the desert;
Isa 63:14 like cattle going down into a valley the Spirit of Adonai had them rest. This is how you led your people, to make yourself a glorious name."
Isa 63:15 Look down from heaven; and see from your holy, glorious dwelling. Where are your zeal and your mighty deeds, your inner concern and compassion? Don't hold back,
Isa 63:16 for you are our father. Even if Avraham were not to know us, and Isra'el were not to acknowledge us, you, Adonai, are our father, Our Redeemer of Old is your name.
Isa 63:17 Adonai, why do you let us wander from your ways and harden our hearts, so that we do not fear you? Return, for the sake of your servants, the tribes who are your possession.
Isa 63:18 Your holy people held your sanctuary such a short time, before our adversaries trampled it down.
Isa 63:19 For so long we have been like those you never ruled, like those who were not called by your name!

 

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Commentary;

Isa 63:17 O Lord, why hast thou made us to err from thy ways, and hardened our heart from thy fear?.... These are the words, not of wicked men among Israel, charging all their errors, hardness of heart, and wickedness they were guilty of, upon the Lord, as if he was the author and occasion of them, and led them into them; but of the truly godly, lamenting and confessing their wandering from the ways, commands, and ordinances of God, the hardness of their hearts; their want of devotion and affection for God; and their neglect of his worship; not blaming him for these things, or complaining of him as having done anything amiss or wrong; but expostulating with him, and wondering at it, that he, who was their loving and tender Father, that he should suffer them to err from his ways, and to wander from his worship, by withholding his grace and withdrawing his presence from them; by leaving them to the corruptions and hardness of their hearts; by chastising them sorely, and suffering the enemy to afflict them in such a severe manner as laid them under temptation to desert the worship of God, and cast off the fear of him. The Jews (f) interpret this of their being hardened from the fear of God, and made to err from his ways by seeing the prosperity of the wicked, and their own long captivity, troubles, and distresses:
return for thy servants' sake, the tribes of thine inheritance; or turn (g); turn from thine anger and displeasure to thy people; or, as the Targum,
"return thy Shechinah to thy people;''
thy gracious and glorious presence, which has been so long withdrawn; or "return" thy people from their captivity, the twelve tribes, thy portion and "inheritance"; and do this "for thy servants' sake"; for the sake of Abraham, Isaac, and Jacob: or because of the covenant made with them; or for the sake of all thy people, who are thy servants, and which also are the tribes of thine inheritance, return unto them.
(f) So Kimchi, Ben Melech, and R. Sol. Urbin. Ohel Moed, fol. 85. 2. (g)שוב "convertere", V. L. Pagninus, Montanus, Calvin, Forerius. (John Gill Exposition of the entire Bible)

 

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He is calling us to return to HIS WAYS,  with understanding and revelation from the Ruach HaKodesh comes t'shuvah, repentance and healing. 

Pride is the biggest reason our heart gets hardened and God allows it to happen because we made the choice not to obey.  When we reject the move of God and hold onto our traditions even though we are shown the truth in His Word, our heart becomes hardened.    The only way to be healed of this 'Heart Disease" is to repent and humble yourself before Him.