Hospital-acquired infections, such as MRSA, kill an estimated 5,000 a year.
The Manchester study was triggered when complementary medicine specialists at Christie Cancer Hospital asked university researchers to test essential oils.
They wanted to ensure they could not harm the patients, whose immune systems are weakened by the treatments.
Dr Peter Warn, who carried out the research, said: "When I tested the oils in the lab, absolutely nothing grew. Rather than stimulating bacteria and fungi, the oils killed them off."
"Our research shows a very practical application which could be of enormous benefit to the NHS and its patients"
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The team then tested 40 essential oils against 10 of the most infectious agents found in hospitals, including MRSA (methicillin-resistant staphylococcus aureus).
Two of the oils were found to kill MRSA and E.coli almost instantly, while a third was found to act over a longer period of time.
However, the researchers say they are unable to reveal which oils carry benefits because of commercial sensitivities.
MRSA is often carried in patients' nostrils, and is currently treated by putting disinfectant on the area to kill the bacterium - which many patients often find unpleasant.
Dr Warn says the essential oils could be used to create much more pleasant inhalation therapies - which he said were likely to have a much higher success rate than the current treatment, which is only effective in around 50% of cases."
Dr Warn said: "We believe that our discovery could revolutionise the fight to combat MRSA and other superbugs."
But he said the team now needed around £30,000 in order to continue its research.
Jacqui Stringer, clinical leader of complementary therapies at Christie Hospital in Manchester, instigated the oils research.
She said: "Our research shows a very practical application which could be of enormous benefit to the NHS and its patients.
The Department of Health evaluates products which are claimed to prevent or treat HAIs before it permits them to be used across the NHS.
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