Eastwoods Consulting
Notes from the East Woods

musings on opportunities in the life science marketplace

        September 2010
  
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Greetings!

This very strange creature can help us think about new directions for business growth.  Please have a read and feel free to let me know what you think. 


Regards,

Paul Danis
Founder and Principal

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This Month's Features
- Cecropia and Business Growth
- Life Science Market Update
- About Eastwoods Consulting
Cecropia and Business Growth

Cecropia
The other day I came across the most ornery looking creature I have ever seen. It was 4 inches long, green and covered in blue, yellow, and orange knobs with little black spikes sticking out of each one - absolutely bizarre like some sci-fi genetics experiment gone wrong.  This cecropia caterpillar is, however, a well-known bug, and eventually will change into a very large and beautiful moth.  The incredible metamorphosis of this guy is similar to how life science companies often evolve their growth strategies.  

After struggling with a certain direction or having market conditions radically change, many companies come face to face with very unpleasant possibilities for growth.  Some of these companies wilt away, but many re-invent/reposition their business or entire companies to get to where the action is.  Here are some examples of metamorphosis in the life sciences.
  • Helicos BioSciences is a pioneer in next generation DNA sequencing and moved from a purveyor of instruments to become a molecular diagnostics company, offering their own tests as well as services.
  • Pfenex had initially offered its bacterial-based protein expression system for production of biotherapeutics, but now has repositioned it to express a large variety of proteins for early stage and preclinical work.
  • Biocept was focused on providing technology for cell isolation but now is developing assays for personalized medicine in early detection, diagnosis and monitoring of cancer
  • Similarly OncoMethylome Sciences moved from out-licensing cancer biomarkers to developing their own diagnostic tests for early cancer detection
  • The most famous repositioning of all is probably the failed heart medicine turned lifestyle hero - Viagra.  This drug repositioning concept is currently a popular approach in the pharmaceutical industry, even having its own dedicated conferences
And it is not just emerging and growth stage companies that change their tune.  Companies such as IBM, PerkinElmer, and GE have all evolved their life science strategies, both through acquisitions as well as internal repositioning.

What are the benefits of changing direction and redefining their strategy?  Surely one has to first admit that things are not going well (or could go much better).  Since wholesale change is not easy there must be a big payback on this:
  • Move up the food chain to higher value/margin products
  • Get away from crowded segments with vicious competition
  • Access larger segments that will continue to grow in size and breadth
  • Reduce internal expenses and leverage current technology in new ways
  • Make shareholders more optimistic about the future
What can you do next:  acknowledge there must be a better way, find the greener grass, and get ready for a big change.   Like the knobby, spiky cecropia that will soon become the biggest moth in North America, changing your business or company direction can be a very healthy metamorphosis leading to a much brighter future.




Life Science Market Update

Index

July Value

Change 12mo.

12 mo. High

12 mo. Low

EC BioTools

609

-1%

738

609

EC BigPharma

724

-2%

801

699

EC Biotech

552

5%

642

484


With the exception of Perkin Elmer, all Tools companies were down for the month, and with Accelrys, Affymetrix, Bruker, Caliper and Luminex down over 10%.  The BioTools Index also notched a 12 month low.  BigPharma was mixed with most companies up or down a few percent on the month.  Biotech retreated from last month with declines leading advances 3 to 1.  Cepheid, Human Genome Sciences, Sangamo and Theravance were all down over 10% for the month.


EC BioIndex August 2010

EC BioIndex


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Many of the life science indices currently available are a mixture of various types of companies. In order to better assess the situation in the different segments, Eastwoods Consulting has created these price-weighted indices for the sectors of large pharmaceutical companies, biotech companies, and life science research tools companies.
  • EC BioTools Index - A, ACCL, AFFX, BEC, BIO, BRKR, CALP, DNEX, HBIO, HLCS, ILMN, LIFE, LMNX, PKI, QGEN, SIAL, TECH, TMO, WAT
  • EC BigPharma Index - JNJ, PFE, GSK, NVS, SNY, LUN, ABT, LLY, AZN, WYE, BMY, NVO, BAX, TEVA, KG, ROG.VX
  • EB Biotech Index - AMGN, GENZ, BIIB, CEPH, GILD, BMRN, AMLN, IDXX, ITMN, SEPR, PDLI, CPHD, ALKS, REGN, VRTX, THRX, HGSI, SGMO, NKTR
  • Prices are taken at the close of each month.
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About Eastwoods Consulting
Eastwoods Consulting

Translating Innovations into Profits for the Life Science Industrysm

Eastwoods Consulting helps life science companies grow their businesses.  Please visit our web site or contact us to learn more about how we help companies succeed in competitive markets.
 


Copyright © 2010, Eastwoods Consulting. This publication may be freely redistributed in full or in part as long as full attribution including our contact information and web address, are included.  Eastwoods is a registered servicemark of Eastwoods Consultng.