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Introducing the Cogent Diamond-Hydride HPLC columns with great separation powers. 

"Nothing Else Like it."
The recently released Cogent Diamond Hydride HPLC columns are part of the very popular TYPE-C silica product line. The Diamond Hydride columns are unmodified TYPE-C Silica but with (patent pending) small amounts of carbon incorporated onto the surface of the silica hydride. This small amount of carbon is a key factor in the unique selectivity and peak shapes for a column that can produce Reverse Phase, Normal Phase or Aqueous Normal Phase chromatography.
One of the many amazing features of this column is that you can retain amino acids directly on the column without derivatizing them before analysis. This announcement shows two more of the many uses of these columns. There is nothing else like this column and it could be a great tool for your lab.
 
Applicaton Example:
Separate Creatine from Creatinine in synthetic urine
          Extracted Ion Chromatogram.
 
Syntheitc Urine LCMS
 
 
 
 
 
 
 
 
 
 
 
 
 
Creatine and Creatinine are typically very difficult to separate from each other. A simple gradient with an MS friendly mobile phase was used to resolve these two compounds. In addition 4-hydroxyproline which has a very similar mass weight as creatine was also easily separated. A powerful combination of an Agilent MSD-TOF instrument (4 digit mass accuracy) and a Cogent Diamond Hydride™ LCMS column takes away guessing from the analysis of metabolites in a complex mixture as shown.
 
Click here for more information on:
 
Application Example:
Very polar metabolites are easily retained
 
Purine bases and nucleosides are separated in this LCMS friendly method. Click on the image for conditions.
 
Metabolites on Diamond Hydride

 
Both guanine and adenosine are polar compounds which elute at the void volume on many leading (excellent) C18 columns. Using a simple mobile phase and the Cogent Diamond Hydride™ column it is possible to retain guanine and adenosine, as well as many other polar compounds. Mixture of the two samples were prepared: 100 µL of each sample and 800 µL of the mobile phase
Diamond Hydride 
 
 
Click here to Learn about these new HPLC columns
Download Our Poster from
ASMS 2007
Click Below:
There are many uses for these columns and if you would like to know more about them, send us an email at
technical.service@mtc-usa.com, phone us or visit our website.
 
Sincerely,
Bill Ciccone
President
MicroSolv Technology Corporation
HPLC Column Connectors
Did you Know that MicroSolv offers great productivity tools for HPLC? Like Sure-Fit column connectors that automatically adjust the pilot length of tubing leading into a colum; it is easy to achieve zero dead volume connections without cutting any tubing.
 
Click on the image or here to check out this time saving laboratory tool and many others.