Did you know that One C18 Column can be used for RP, NP and ANP (HILIC Type)

MicroSolv Technology Corporation Since 1992

HPLC, CE, CEC & BioAnalytical Technology

Yes, one C18 HPLC Column can work in Reverse Phase, Normal Phase and Aqueous Normal Phase...efficiently and reversibly.

Many of our customers were surprised to learn that there are HPLC Columns that can give them such a wide range of selectivity and usefulness. The Cogent TYPE-C brand of columns (first in class) are the only HPLC columns that can do this. What is even better is that there is no hysteresis when changing from mode to mode. This can be accomplished very fast.

Click on one of the links below and see how these columns are different from what you already have and what they can do for you today or in one of your future methods.

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Application Notes

Click here to visit our website for other Application Notes for TYPE-C Columns

Also Available in:

Bidentate C8

Cholesterol

Silica-C (unmodified)

Click on the above logo for Frequently Asked Questions about TYPE-C Silica HPLC Columns

	Reverse Phase- 100% Aqueous Mobile Phase without any loss of RT with many uses. Retain Oxalic, Formic & Acetic Acid then Na Azide and other analytes.
With our Cogent Bidentate C18, you can use 100% Water as the mobile phase or other standard RP mobile phase combinations and get wonderful retention and separation of difficult compounds. Click below to view application note and Peak ID: Total Aqueous Mobile Phase

	Normal Phase- Separation by Functional Groups using Hexane in MP.
*C18-Normal Phase without drying your solvents!* In this application of our Cogent Bidentate C18 column you can see how our customers used the same column as shown above to separate these prodrugs. Easy and reproducibly. Click below to view Application Note and see the structures of these compounds: Normal Phase on C18

Aqueous Normal Phase-

Retain in Normal Phase with Reverse Phase Solvents.

Better than a HILIC mode, Aqueous Normal Phase (ANP) will retain polar and non polar compounds in the same run; Isocratically.

Glyburide is very non polar (logP >3) and Metformin is highly polar (logP <-1.0) but both are retained in two different isocratic runs.

Vary the concentration and change the RT.

Click below to see structures and mobile phase conditions.

Polar and Non Polar on Same C18

There are many uses for these columns and if you would like to know more about them, send us an email at technicalservice@mtc-usa.com, phone us or visit our website.

Sincerely,

Bill Ciccone

President

MicroSolv Technology Corporation

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