BenaGene, composed of equal portions of the metabolite "oxaloacetate" and Vitamin C has been gaining interest among physicians as more and more scientific data comes in.  One of the reasons for the "buzz" is a series of articles showing that disabling a metabolic enzyme, "Pyruvate Carboxylase", prevents glucose-stimulated insulin secretion and proliferation of the beta-cells that make insulin; while conversely, increasing Pyruvate Carboxylase activity increased insulin sensitivity, production and allowed the growth of the beta cells that make insulin. (Farfari, 2000; Liu 2002, 2005; Hasan 2008).  Additionally, Palmer (2006) found that an alteration in the Pyruvate Carboxylase gene was significantly associated with an acute insulin response.

New work from the "Research Institute for Children" in New Orleans (Han, Journal of Endocrinology, 2010) now suggest that the functionality of Pyruvate Carboxylase is inhibited by high glucose levels, and that this inhibition may be tied directly to the development of Type II diabetes.

The work of Han in suggesting that decreases in Pyruvate Carboxylase activity may play a part in the causation of diabetes is supported by a report from MacDonald (Diabetologia, 2009), which shows a 65% reduction in Pyruvate Carboxylase activity in Type II diabetics.

Can the restoration of Pyruvate Carboxylase activity restore insulin functionality, and perhaps more importantly, allow the body to regenerate the critical beta cells needed for insulin secretion?  While successful in animals, this concept has not been proven in humans.  But it is very exciting.

So why the "buzz" about benaGene oxaloacetate?  It's because the enzyme "Pyruvate Carboxylase" participates in only one molecular reaction in the body:  The conversion of pyruvate into oxaloacetate  (See: http://www.ncbi.nlm.nih.gov/gene/5091 )

Interestingly, Sodium Oxaloacetate was identified many years ago in Japan as a viable method to support glucose system functioning - See "Studies on the Anti-Diabetic Effect of Sodium Oxaloacetate".  The results show an average drop in fasting glucose levels of 24% in diabetic patients within 45 days.  No side effects were noted.

So what does this all mean for oral supplementation with benaGene brand oxaloacetate?  We can't be sure without several long and expensive clinical trials, which will probably never be performed, as oxaloacetate is a natural compound, and patenting of natural compounds is difficult.  Without the patent rights, pharmaceutical companies are understandably reluctant to spend an average $800 Million in pushing a compound through the US FDA approval process.   But it is interesting, and the "Buzz" is increasing.....

benaGene brand oxaloacetate provides 100 times the normal amount of oxaloacetate that is received in a typical diet.  Supplementation with this natural human metabolite provides a mechanism to positively modify enzyme response to mimic a calorie restricted metabolic state.  

benaGene is available from your anti-aging doctor or from our website store at www.benaGene.com

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