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| Weight Management |
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Learn how Calorie Restriction mimetics such as benaGene can help you keep the excess pounds from coming back after your successful diet.
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Quote of the Day Wrinkles should merely indicate where smiles have been. --Mark Twain |
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Oxaloacetate and Tissue Protection
Greetings!
At times it seems like everything is trying to wear us down. The good news is that some compounds actually protect us from damage-- and we can all use that. Oxaloacetate (a key ingredient in benaGene) is one of those protective compounds.
Independent research has shown oxaloacetate protects tissues on a molecular and cellular basis. These protections result in increases in average and maximal lifespan when oxaloacetate is supplemented into the diet (animal data-- human data on lifespan will take 130 years to fully evaluate.......). Consider some of the specifics:
- Oxaloacetate has been shown to protect pancreatic beta cells (the ones that produce insulin) and inhibit type II diabetes caused by zinc toxicity.
- Oxaloacetate has been shown to protect RPE tissues in the eye (again due to over-exposure to zinc).
- New research now shows that oxaloacetate may now be effective in reducing or eliminating brain damage from acute head injury, epilepsy or stoke if given within 2 hours of the incident. The mechanism is the reduction of excess glutamate (that leads to neurological damage) through the creation of alpha-ketoglutarate via the enzyme Glutamate-Oxaloacetate Transanimase GOT).
- Oxaloacetate protects cells from aluminum and mercury toxicity by creating an intercellular reductive environment. Some bacteria actually shift their metabolism to overproduce oxaloacetate in order to live in heavy-metal-rich environments.
- Oxaloacetate has been shown to protect mitochondrial DNA from damage from toxins such as kianic acid.
- Oxaloacetate has been shown to protect tissues from hydrogen peroxide damage.
- Oxaloacetate has been shown to protect tissues from organic toxins such as hydrazine.
- Oxaloacetate is a powerful anti-oxidant and inhibits TBARS production in the brain.
It's nice to know there is some protection on your side-- especially from a human metabolite-- one that is central to energy production. If you would like to read more information on all these tissue protections, drop us an email and ask for the physician's reference sheet.
benaGene brand oxaloacetate provides 100 times the normal amount of oxaloacetate that is received in a typical diet. Supplementation with this natural human metabolite provides a mechanism to positively modify enzyme response to mimic a calorie restricted metabolic state.
benaGene is available from your anti-aging doctor or from our website store at www.benaGene.com
benaGene. "Time Enough for Life" TM |
| May I send you our latest research? |
We have had several recent peer-reviewed publications.
The most recent is
"Modification of the NAD+/NADH Ratio Via Oxaloacetic Acid Supplementation to Mimic Calorie Restriction Metabolic Pathways and Increase Lifespan"
Alan Cash, Anti-Aging Therapeutics Volume XII, American Academy of Anti-Aging Medicine, December 2010
"Oxaloacetate Enhances Resistance to Fatigue in In vitro Mouse Soleus Muscle"
Daniel Hogan, Leonardo Nogueira, Michael C. Hogan, FACSM Division of Physiology, Department of Medicine, UCSD, La Jolla, CA presented at the American College of Sports Medicine, 2010
Also check out " Oxaloacetic Acid Supplementation as a Mimic of Calorie Restriction". To down-load this free paper, go to http://www.bentham.org/open/tolsj/openaccess2.htm click on "Hot Topic" calorie restriction mimetics, and download full article. Alternately, you can send me an e-mail at acash@benaGene.org and I will send you the paper. Thanks for your interest !
Our previous paper "Oxaloacetate Increases Lifespan", which documented a 25% increase in lifespan using oxaloacetate supplementation is available here: http://www.ncbi.nlm.nih.gov/pubmed/19793063 |
| About benaGene | |
benaGene is a new concept in nutritional supplements. Composed of Vitamin C and the natural human metabolite oxaloacetate in order to mimic a calorie restricted state, benaGene positively affects gene expression. benaGene has been proven to increase the lifespan of laboratory animals by 25% (p << 0.001).
You can benefit with benaGene by providing glucose system support in addition to receiving the anti-aging benefits. A powerful natural AMPK activator, oxaloacetate has been shown to lower fasting glucose levels in a clinical trial. Additionally, benaGene is an excellent choice after a diet in order to reduce weight rebound as benaGene down-regulates the genes that produce and store fat (by approximately 50%, animal studies).
benaGene is available from your anti-aging doctor or from our website store at www.benaGene.com |
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Thank you for your interest in benaGene. For more information, go to our information web site at www.benaGene.com. If you have any questions concerning this dietary supplement, please do not hesitate to contact me directly. Whereas we do not provide medical advice, we can provide you with the references and research we have done in regards to oxaloacetic acid supplementation. We have tremendous science behind benaGene, but the science will not help anyone if benaGene is not used. Please help us to spread the word about this unique dietary supplement.
Sincerely,
Alan Cash Terra Biological LLC |
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