IonSense, Inc
  December 2011  
What's New with DART? 
The latest developments and news on DART Mass Spectrometry


We would like to wish all of you a very happy Holiday Season and all the best for the New Year.  We also would like to thank you for your support and interest in DART.  Many of you have given us valuable feedback this year on the applications as well the new products, and we appreciate this very much.

Below are a few recent publications from your DART colleagues on counterfeits, PEG's and nerve agents.  Also if you have a new publication, please let me know, and we would be happy to feature it in future newsletters.

Please have a look and contact me if you have any questions or comments. Thanks.


BM signature

Brian Musselman
President and CEO
IonSense, Inc.
Latest Publications on DART   

Here are some recent publications that you may find interesting.  If you would like more information, just go to the abstract and send the author a note.


E. S. Chernetsova , P. O. Bochkov, G. V. Zatonskii, R. A. Abramovich 

Shared Equipment Usage Research and Education Center, People's Friendship University of Russian, Moscow, 117198 Russia; Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, 125315 Russia; Tokyo Boeki (Moscow Office), Moscow, Russia 


Pharmaceutical Chemistry Journal, Volume 45, Number 5, 306-308, DOI: 10.1007/s11094-011-0622-y


The possibility of using DART mass spectrometry for the identification of active ingredients in tableted drugs has been studied. Analytical results for some drugs such as glycin, nootropyl, anaprilin, mexidol, and biseptol are presented. The benefits and limitations of DART mass spectrometry as applied to fast screening of tableted pharmaceuticals for detecting counterfeits are discussed.

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA

Presented here are findings describing the spatial-dependence of sensitivity and ion suppression effects observed with direct analysis in real time (DART). Continuous liquid infusion of dimethyl methyl phosphonate (DMMP) revealed that ion yield "hot spots" did not always correspond with the highest temperature regions within the ionization space. For instance, at lower concentrations (50 and 100 μM), the highest sensitivities were in the middle of the ionization region at 200 °C where there was a shorter ion transport distance, and the heat available to thermally desorb neutrals was moderate. Conversely, at higher DMMP concentrations (500 μM), the highest ion yield was directly in front of the DART source at 200 °C where it was exposed to the highest temperature for thermal desorption. In matching experiments, differential analyte volatility was observed to play a smaller role in relative ion suppression than differences in proton affinity and the relative sampling positions of analytes. At equimolar concentrations sampled at the same position, suppression was as high as 26× between isoquinoline (proton affinity 952 kJ mol-1, boiling point 242 °C) and p-anisidine (proton affinity 900 kJ mol-1, boiling point 243 °C). This effect was exacerbated when sampling positions of the two analytes differed, reaching levels of relative suppression as high as 4543.0 +/-1406.0. To mitigate this level of relative ion suppression, sampling positions and molar ratios of the analytes were modified to create conditions in which ion suppression was negligible.




E. S. Chernetsova, M. V. Ovcharov, G. V. Zatonskii, R. A. Abramovich and I. A. Revelskii  

Peoples Friendship University of Russia, ul. Miklukho-Maklaya 6, Moscow, 117198 Russia, National Research Centre "Kurchatov Institute", pl. Akademika Kurchatova 1, Moscow, 123182 Russia, State Institute of Biological Instrument Design (GosNIIBP), State Science Center of the Russian Federation, Volokolamskoe sh. 75/1, Moscow, 123424 Russia, Chemistry Department, Lomonosov Moscow State University, Moscow, 119991 Russia 


Journal of Analytical Chemistry Volume 66, Number 13, 1348-1351, DOI: 10.1134/S1061934811130016





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About IonSense  
IonSense, Inc. provides open-air mass spectrometry solutions to the fields of food safety, forensics, drug development, and chemical analysis. They manufacture and develop direct analysis in real time (DART®) technology licensed from JEOL USA, Inc. and atmospheric solids analysis probe (ASAP™) licensed from M&M Consulting.

DART and ASAP Sources are available for most commercial LC/MS systems.  Look here to see if your system is DART-ready.  And  check here to see if your system is ASAP-ready.