IonSense


December
2008 		What's New with DART?
The latest developments and news on DART Mass Spectrometry
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Greetings!
 
We'd like to let you know about a couple recent articles -  removing some of the mystery of DART as well as application in ADME.

The first gives us insight into the mechanisms of DART for negative ions.  The folks at UT have shown it to have similarities with APPI, albeit easier to do.

The second paper further develops the utility of DART for rapid, simple quantification of compounds in ADME applications.

Please have a look and let us know what you think.  Thanks.

Regards,

Brian Musselman
COO, IonSense
How DART Works - Negative Ions

PFBRecent work by John Bartmess and Liguo Song at the University of Tennessee has shed light on the mechanisms of DART when used to produce negative ions.

They examined a wide range of compounds and found that four ionization mechanisms are active, including electron capture, dissociative electron capture, proton transfer, and anion attachment.  In comparison with negative Ion atmospheric pressure photoionization, DART was found to be easier to operate.  Using the DART they also investigated the production of background ions from LC solvents and APPI dopants.

Please take a look at the abstract and if you would like more information on this, please contact us.
Easy ADME - No Sample Cleanup or Chromatography


ADMEShaoxia Yu and Jing-Tao Wu from Millennium Pharmaceuticals have collaborated with IonSense to develop automated DART - triple quadrupole mass spectrometer methods for the rapid quantification of compounds in biological matrices. This paper is available from Analytical Chemistry Online and will be published in March.

"Bioanalysis without Sample Cleanup or Chromatography: The Evaluation and Initial Implementation of Direct Analysis in Real Time Ionization Mass Spectrometry for the Quantification of Drugs in Biological Matrixes"

They demonstrated a dynamic range of four orders of magnitude, and analyzed biological samples from both in vivo pharmacokinetic studies and in vitro microsomal/S9 stability studies.  They concluded that the results are similar to those obtained with conventional LC/MS/MS methods, and that this method has "demonstrated significant potential for high-throughput bioanalysis."

Click here to view the abstract, and please let us know if you would like any additional information.
About IonSense
 
IonSense, Inc. is developing technology for the analysis of materials by direct analysis in real time or DART mass spectrometry. DART MS provides rapid qualitative and quantitative sample analysis of bioanalytical, medicinal, forensic, and chemical synthesis products by ambient mass spectrometry.

DART Sources are available for most commercial LC/MS systems.  Look here to see if your system is DART-ready.



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