What's New with DART?
The latest developments and news on DART Mass Spectrometry

We'd like to let you know about two recent articles demonstrating the rapid analysis of real as well as fake drugs.

The first shows how DART could be an alternative to typical LC/MS/MS of drugs in plasma providing the same information in a fraction of the time

The second provides a report on how fake malaria drugs in South East Asia are quickly ascertained using DART.   Please have a look and let us know what you think.  Thanks.


Brian Musselman
COO, IonSense
Rapid Quant of Drugs in Plasma

WarfarinThe folks at Roche in Palo Alto, CA have shown how DART can be a viable alternative to LC/MS/MS of drugs in plasma.  Their paper in RCMS showed that reasonable precision and accuracy were achieved, and that the limit of detection for 80% of the tested compounds is sufficient for pharmaceutical drug discovery support.

As they said, "Because of its simplicity, fast data acquisition (3-5 s) and low cost, DART has the potential to significantly impact quantitative pharmaceutical analysis in biological matrices."

Please take a look at the abstract and if you would like more information on this, please contact us.
Rapid Determination of API's -- What's in Your Pill?

TylenolA collaboration across 4 continents has given us a view into DART's ability to affect public health issues. 

"Characterization of "Yaa Chud" Medicine on the Thailand-Myanmar Border: Selecting for Drug-resistant Malaria and Threatening Public Health"

This study published in the American Journal of Tropical Medicine and Hygiene shows how the tablets' active ingredients were rapidly determined using DART as well as LC/MS.   A variety of active ingredients were found including acetaminophen, chlorpheniramine, chloroquine, tetracycline/doxycycline, and quinine. Less than a quarter of the samples contained potentially curative medicine for malaria, and a majority had medicines potential harmful in pregnancy.

Click here to view the results with DART, and this link will bring you to the complete paper.
About IonSense
IonSense, Inc. is developing technology for the analysis of materials by direct analysis in real time or DART mass spectrometry. DART MS provides rapid qualitative and quantitative sample analysis of bioanalytical, medicinal, forensic, and chemical synthesis products by ambient mass spectrometry.

DART Sources are available for most commercial LC/MS systems.  Look here to see if your system is DART-ready.

Join our mailing list!