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Rapid Quant of Drugs in Plasma
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 The folks at Roche in Palo Alto, CA have shown how DART can be a viable alternative to LC/MS/MS of drugs in plasma. Their paper in RCMS showed that reasonable precision and accuracy were achieved, and that the limit of detection for 80% of the tested compounds is sufficient for pharmaceutical drug discovery support.
As they said, "Because of its simplicity, fast data acquisition (3-5 s) and low cost, DART has the potential to significantly impact quantitative pharmaceutical analysis in biological matrices."
Please take a look at the abstract and if you would like more information on this, please contact us.
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Rapid Determination of API's -- What's in Your Pill?
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 A collaboration
across 4 continents has given us a view into DART's ability to affect
public health issues. " Characterization of "Yaa Chud" Medicine on the
Thailand-Myanmar Border: Selecting for Drug-resistant Malaria and
Threatening Public Health" This study published in the American Journal of Tropical Medicine and Hygiene shows how the tablets' active ingredients
were rapidly determined using DART as well as LC/MS. A variety of active ingredients were found including acetaminophen, chlorpheniramine, chloroquine, tetracycline/doxycycline, and quinine. Less than a quarter of the samples contained potentially curative medicine for malaria, and a majority had medicines potential harmful in pregnancy. Click here to view the results with DART, and this link will bring you to the complete paper. |
