New Products
Applied BioPhysics is proud to introduce two new instruments: the ECIS Z and the ECIS Z Theta
The ECIS Z system replaces the 1600 instrument that measures impedance and the
ECIS Z Theta replaces the 1600R system that measures impedance, resistance and
capacitance. Both systems can monitor 8,
16 or 96 well tissue culture arrays. A new software program, based on the matlab software engine,
uses an integral mathematical model that can report time course changes in the
barrier function of confluent cell layers as well as other cell parameters (see article below for more details on the software update).
Multi-Pump Flow System
We now offer a flow option providing the ability to
measure cell changes under dynamic flow conditions. The pump is controlled by the ECIS
software. Up to 8 pumps can be
simultaneously controlled. The pump system includes the controller, pump, bottles, tubing and a starting supply of flow arrays.
Company News
Dr. Charles Keese has assumed responsibility of company President and Dr. Ivar Giaever is now Chief Technical Officer (CTO).
Applied BioPhysics has hired two new employees:
Dr. Christian Renken is our new Applications Scientist. He
received his Ph.D. in Biology from UCSD and his BS in Physics from UCLA.
Christian has broad experience in cell biology with publications in the fields
of apoptosis, calcium signaling, membrane thermodynamics, mitochondrial
physiology and structural biology. He will be developing new applications for
ECIS and reaching out to customers to learn how current ECIS techniques
may be improved or developed to better serve the ECIS community. Researchers
interested in collaborating with Christian can reach him directly at renken@biophysics.com
Ms. Nancy Vlahos is our new Technical Sales Associate. She
received her MS in Environmental Science from Yale University and her BS in
Chemistry from SUNY Purchase. Nancy will
be serving the North American market consulting with researchers to match ECIS
technology with their individual needs and goals. To begin a conversation with Nancy please
contact her at vlahos@biophysics.com.
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| Software Update v.1.2.8
Last year Applied BioPhysics
began a project to develop a software platform that consolidates all
instrument control and data analysis into a single package. The new
software is based on the Matlab engine which provides an advanced user
interface, graphing capabilities and data analysis.
The new ECIS software provides a more user-friendly interface, the ability to load
multiple files, quick modeling, easy export of data and graphs, and many more
features that make data acquisition and analysis intuitive for all ECIS users.
The software is available for both Windows (XP Vista) and Mac OSX (Intel) and
supports the following ECIS systems:
- Models 1600 and 1600R (Windows
only for acquisition)
- ECIS Z and Z-Theta (Windows or
Mac OSX for acquisition)
- 16 and 96 well array stations
- Heidolph and Applied BioPhysics flow systems
Existing data files from Models
1600 and 1600R can be readily imported and analyzed with the new software. The software is available as a free upgrade to all ECIS
instruments owners and any users who wish to analyze their ECIS data
off-line.
Please contact info@biophysics.com for details on how to
get the latest version (v.1.2.8).
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ECIS Webinar Schedule 2009
ECIS Application Webinars review the topics listed below in 20 minute, web-based, interactive seminars presented by Dr. Charles Keese. All webinars will be held at 11:00am ESDT. To register for a webinar, please email info@biophysicis.com. -ECIS Theory - Tuesday, July 7 -Cell Invasion/Extravasation - Tuesday, July 21 -ECM Measurements/Cell Wounding - Tuesday, August 4 -Barrier Function - Tuesday, August 18 -Electroporation - Tuesday, September 8 -Cell Migration - Tuesday, September 22 -Signal Transduction - Tuesday, October 6 -Toxicology with ECIS - Tuesday, October 20 For more information, please visit: http://www.appliedbiophysics.com/contactUs/webinar.html
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New Publications
Irina Gorshkova, Donghong He, Evgeny Berdyshev, Peter Usatuyk, Michael Burns,
Satish Kalari, Yutong Zhao, Srikanth Pendyala, Joe G. N. Garcia, Nigel J. Pyne,
David N. Brindley,and Viswanathan Natarajan, Protein Kinase C-Regulates Sphingosine1-Phosphate-mediated Migration of Human LungEndothelial Cells through Activation of Phospholipase D2,Protein Kinase C-, and Rac1. Journal of Biological Chemistry (Vol. 283, No. 17, April 25, 2008). Theresa M. Curtis, Joel
Tabb, Lori Romeo, Steven J. Schwager, Mark W. Widder and William H. van der
Schaliec, Improved cell sensitivity and longevity in a rapid impedance-based toxicity sensor. Journal of Applied Toxicology (January 2009). Theresa M. Curtis, Mark W. Widder, Linda M. Brennan, Steven J. Schwager, William H. van der
Schaliec, Julien Feyand Noe Salazar, A portable cell-based impedance sensor for toxicity testing of drinking water. Lab Chip, 2009, DOI:10.1039/b901314h.
Have you recently published an article that includes the use of ECIS? If so, submit your publications to Applied BioPhysics via email to Nancy Vlahos at vlahos@biophysics.com. We
will announce your article in our newletter, post it on our website and send you 2
FREE 8 well arrays!
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Visit Us at Upcoming Events!
Applied BioPhysics will have ECIS demonstrations and informational
literature at the following events:
 1st ECIS Research Meeting University of Regensburg Regensburg, Germany July 30 - 31st Talks given by ECIS users from different fields of applied and basic research will address a broad range of established ECIS applications including cell
adhesion monitoring, the ECIS-based wounding healing assay and ECIS as a
screening tool in drug and cytotoxicity testing. It will include
presentations by the founders: Dr Ivar Giaever, Nobel Laurette, and Dr
Charles Keese in addition to researchers who will present their recent data and findings.
Drug Discovery & Development 2009
World Trade Center Boston
Boston, MA
August 3-6, 2009
SBS: Screening Stem Cells
Boston Park Plaza Hotel
Boston, MA
September 2-3, 2009
Genetics and Genomics of Vascular Disease
Cape Codder Resort
Hyannis, Cape Cod, MA
September 13-16, 2009
American Society for Cell Biology - 49th Annual Meeting
San Diego Convention Center
San Diego, CA
December 5-9, 2009
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| Tip of the Month - Improving Experiment Repeatability
Before inoculating wells with cells and running ECIS experiments, we
recommend using the new electrical stabilization feature that is part of most ECIS instruments. Following electrical stabilization, we also recommend letting the electrode
equilibrate in medium for at least 15 minutes before inoculation to allow
impedance values to settle. This will minimize impedance drift during an experimental run and establish
good reproducibility from one experiment to another.
For more information on improving experiment repeatability, please visit the ECIS FAQ page of our website.
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| ECIS Humor
Need a good laugh? Visit the ECIS Cartoons page of our website to view cartoons by Catherine, our in-house cartoonist to start your day with a smile.
Are you the creative type? Submit one of your own cartoons; if we post it on our website we will send you a free array!
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