Center for Biophotonics Science & Technology Newsletter  

May Highlights 2010
In This Issue
Science Highlights
Education Highlights
KT Highlights
Awards & Recognitions
Calendar of Events
Grants of Interest
NSF logo 
Work supported by the National Science Foundation
Cooperative Agreement No. PHY-0120999.
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Dr. Dennis MatthewsFor the last few months we have been busy meeting with our UCD Stakeholders and discussing opportunities for our Center's sustainability.  We're looking forward to working with the NSF, UC Davis and our regional partners, such as SARTA MedSTART and the TIRHR, as a means to further our on-going research, education and knowledge transfer programs in the field of Biophotonics and ultimately, to make our Center self-sustaining.

In other exciting news, CBST will be hosting our NSF Site Review Committee on June 2-3, 2010 at UC Davis.  CBST and our affiliates will have the opportunity to update the committee on our accomplishments from 2009-2010, as well as our most recent highlights from 2009-2010.

In closing, we're currently organizing our CBST Annual Retreat (scheduled for July 12-14, 2010), which will focus on "Biophotonics in Pathology".  Currently, we have confirmed 6 invited speakers (Christopher H. Contag, Lydia Howell, Steve Jacques, Richard Levenson, Rupa Rao, and Agim Beshiri).  Please stay tuned for more exciting details to follow within the coming weeks.

~Dennis Matthews, Ph.D. CBST Director
CBST Research Highlights
Fluorescent Probe for Oral Cancer - May 6, 2010
Dr. Laura Marcu, Professor of Biomedical Engineering at UC Davis.
Laura Marcu, PhD
On May 6, 2010 the UC Davis News & Information reported on a new research finding: Fluorescent Probe for Oral CancerDr. Laura Marcu's laboratory collaborated with Dr. Gregory Farwell's group in the Department of Otolaryngology at the UC Davis Cancer Center to develop the fiber-optic probe

Professor Marcu was quoted as saying, "There's a lot out there about breast, prostate and brain cancer, but people are not so aware about oral cancer and its devastating consequences.  People don't think to look for it, and there isn't any routine screening." (

The article mentions the following: "that the probe stimulates molecules in the patient's tissues with a laser and soome of these molecules naturally respond by re-emitting fluorescent light. The device rapidly detects and analyzes this light using a process called time-resolved fluorescence spectroscopy (TR-LIFS), which provides information about the types of molecules present.  By using sensitive measurements of the change in fluorescence over time, surgeons can see the tumor margins even as they are cutting the tissue."

To read more about how Marcu and Farwell's team have recruited nine human volunteers, to view the FLASH VIDEO, and how they are publishing in an upcoming issue of the Journal of Otolaryngology - Head and Neck Surgery, please click on or
Meet the Researcher - Dr. Kelly Nash
Dr. Kelly Nash, Assistant Professor at UTSADr. Kelly Nash is an Assistant Professor in the Department of Physics and Astronomy at the University of Texas at San Antonio.  Dr. Nash received her B.S. in Physics from Dillard University, New Orleans, LA and her M.S. in Applied Physics from the University of Michigan, Ann Arbor, MI.  She attended the University of Texas San Antonio where she received her Ph.D. in Physics in 2009.  During her graduate studies she broadened her physics knowledge to include a more interdisciplinary approach, which included expanding her studies to include chemistry and biology.  

As a newly appointed Assistant Professor her research interest encompasses polymer nanocomposites and dynamical processes in excited states of rare earth materials.  In UTSA's CATALYST The Magazine of The College Sciences Spring 2010, Dr. Nash was quoted in the Ladies First: Three alumnae lead the way for minority women in science article saying, "I always wanted to teach and to do research, and I feel like this is a good place and an exciting time to be at UTSA" (  As a female physicist she "encourages young women to think of themselves as leaders, pioneers taking a nontraditional road".  She says, "You should enjoy the fact that what you're doing is a challenge.  You have to love everything - education and learning overall".  To read more, please visit (an article by Amanda Beck).

Current projects include:
· Multifunctional nanoparticles based on dielectric core/metal shell structures assembled through use of organic polymers. These materials exhibit fluorescent, magnetic and plasmonic behaviors useful for biological and other photonic applications

· Rare earth doped glasses and nanomaterials
o    Radiative and nonradiative processes
o    Anti-Stokes cooling behaviors
o    Magnetic properties

Technical Capabilities and Instrumentation:
· Optical spectroscopy - Absorption, emission, lifetime measurements
· Microscopy : AFM, TEM, SEM
· Various excitation sources including Lasers: Ti:Sapphire, Argon Ion, NdYVO4
· Near infrared imaging for biological applications.

Laboratory member:
Zannatul Yasmin, 1st year graduate student

Abstracts and Presentations: 25 (since 2003, four invited)

Journal Articles: 20 (Abbreviated list below)
1.    John Gruber, Gary Burdick , Uygun Valiev , Kelly L. Nash, Sharof Rakhimov, and Dhiraj Sardar. "Energy Levels and Symmetry Assignments for Stark Components of    Ho3+(4f10)in Yttrium Gallium Garnet (Y3Ga5O12)," J. Appl. Phys. 106, 113110:1-12 (2009).
2.    Kelly L. Nash, Robert C. Dennis, Nathan J. Ray, John B. Gruber and Dhiraj K. Sardar. "Absorption Intensities, Emission Cross Sections and Crystal Field Analysis of Selected Intermanifold Transitions of Ho3+ in Ho3+:Y2O3 Nanocrystals," J. Appl. Phys. 106 063117 (2009).
3.    Kelly L. Nash, Robert C. Dennis, John B. Gruber and Dhiraj K. Sardar. "Intensity Analysis and Energy-Level Modeling of Nd3+ in Nd3+:Y2O3 Nanocrystals in Polymeric Hosts," J. Appl. Phys. 105 033102 (2009).
4.    Gary W. Burdick, John B. Gruber, Kelly L. Nash, and Dhiraj K. Sardar. "Analyses of 4f11 Energy Levels and Transition Intensities Between Stark Levels of Er3+ in Y3Al5O12", Spectroscopy Letters: Spectroscopy of Lanthanide Materials II (in press, 2009).
5.    Gagik Demirkhanyan , Edvard Kokanyan, Radik Kostanyan, John Gruber, Kelly Nash and Dhiraj K. Sardar. "Phonon effects on zero-phonon transitions between Stark Levels in NaBi(WO4)2:Yb3+," J. Appl. Phys. 105, 063106 (2009).

Kelly L. Nash, Ph.D.
Assistant Professor
Department of Physics and Astronomy
University of Texas at San Antonio
One UTSA Circle, San Antonio, TX 78249
Phone: 210-458-6153
E-mail: [email protected]
CBST Education Highlights
Sacramento Regional Science & Engineering Fair - March 2010
Sacramento Regional Science & Engineering FairNine Sacramento High School CURE students presented research projects at the March 2010 Sacramento Regional Science and Engineering Fair.  Of these students, Lillian Williams was awarded 1st place in Environmental Science for her research on "The Effect of Biodegradable and Non-biodegradable Carwash on Pansy Plants" and Victor Reid-Vera was awarded 2nd place in Environmental Science for his research on "The Effect of Heat on Ivy's Ability to Produce O2 and take in CO2". Darius Graham received an Honorable Mention for his research on "The Effect of Vitamin B17 on Blackworm Growth". Lillian  Williams continued on to the 59th Annual California State Science Fair, which was held May 17-18, 2010. 

To read more about the State Science Fair, please click on
News 10 Student Scholar
News 10 Student Scholar for April 2010 - Nicholas Banford
News 10 Student Scholar
Nicholas Banford
, a Sacramento High School Senior who has participated in the CBST program, was selected as the News 10 Student Scholar for April 2010

The interview aired on News 10 at 5 PM on April 8, 2010 and the story can be found online at:

To qualify for the Student Scholar Award, the student must meet two of the three criteria:
1. Must be a member of a group that historically falls into the academic achievement gap (African American, Latino, Southeast Asian immigrant, lower-income family)

2. Volunteers a significant amount of time, effort and/or knowledge to programs intended to help close the academic achievement gap.

3. Enrolled in advanced-thinking classes (AP, Honors, HISP, Baccalaureate) with a minimum GPA of 3.25.
CURE/EOSA/Hiram Johnson Biophotonics Research Symposium - May 20, 2010
On Thursday, May 20, 2010 thirty-five students from East Oakland School of the Arts (EOSA), along with their teacher Sean Tamarisk and Dr. Susan Spiller from Mills College, 6 Sacramento High School CURE students who worked with David Marks, and 2 students from Hiram Johnson who worked with Vlastimil Krbecek all presented their research projects at the Biophotonics Research Symposium at the NSF Center for Biophotonics Science & Technology (CBST) in Sacramento, California. 

EOSA Research Symposium May 2010CBST researchers, graduate students, and teachers served as judges for the posters. 
Awards were given for ten categories:
1. Most Creative Research Question: Jamie Hudson & Trina Germaine, East Oakland School of the Arts. Whose feet will have more bacteria on them: someone who wears sandals all the time or someone who wears shoes?
2. Best Well-Defended Conclusion: Victor Reid-Vera, Sacramento High School. What would happen if global warming continued to escalate? How would it affect us since we so desperately rely on plants to produce O2 for our bodies?
3. Best Representation of Data: Lillian Williams, Sacramento High School. If the biodegradable car wash has less effect than non-biodegradable car wash on plant health, then higher concentrations of non-biodegradable soap will affect plant color and posture more than the biodegradable soap.
4. Best Collaborative Team Project: Wesley Sims and Joshua Scranton, East Oakland School of the Arts. To what extent does lack of sleep affect your hand/eye coordination and reflex response?
5. Best Background Research: Sabrina Shelton, East Oakland School of the Arts. Are students more likely to pass a test if they eat breakfast?
6. Best Experimental Approach: Angelica Wilcher & Thomas Butler, East Oakland School of the Arts. Does playing basketball help you concentrate during a test?
7. Best Ingenuity in a Project: Raven Chambers, Sacramento High School. To see how different light colors affect photosynthesis and determine if geranium plants can survive under different color light filters.
8. Best Attitude Towards Scientific Research: Nkauj Thao, Hiram Johnson High School. What method of hand washing and hand sanitizing works best in reducing bacteria?
9. Best Use of Images on Poster: Shelia Kidd, Tre'Sor Hines, Johnathan Hill & Jamarr McDaniel, East Oakland School of the Arts. Will your heart rate increase as much the second time you watch a scary movie as it did the first time you saw it?
10. Best Overall Presentation: Yen Nguyen, Hiram Johnson High School. Prediction of Tyrosine Sulfation in Voltage-gated Potassium Channels.

The CURE students also judged the students' presentations and an overall first, second and third place was awarded as follows:
1st Place: Yen Nguyen, Hiram Johnson High School. Prediction of Tyrosine Sulfation in Voltage-gated Potassium Channels.

2nd Place: Angelica Wilcher & Thomas Butler, East Oakland School of the Arts. Does playing basketball help you concentrate during a test?

3rd Place: Jamie Hudson & Trina Germaine, East Oakland School of the Arts. Whose feet will have more bacteria on them: someone who wears sandals all the time or someone who wears shoes?
CBST Knowledge Transfer Highlights
CBST Receives Additional Support from The Keaton Raphael Memorial
The Keaton Raphael Memorial (KRM) recently gifted CBST $80,000.  CBST will use the money for two purposes.   First, to re-emphasize our research efforts in applications of Raman spectroscopy to pediatric cancers.  Secondly, to fit the model of what the UC Davis business school students identified as a path to commercialization of this technology (i.e. develop a diagnostic test to run initially as a CLIA lab as a niche product that enables entry of the technology into the market, while continuing to develop clinical applications of the technology that have broader focus, including therapeutics and additional diagnostics).
With the support from the KRM the Center proposes to: (1) demonstrate the value of the Laser Tweezer Raman technology at UCD using CBST facilities; (2) form a commercial entity to make instruments or services more broadly available; and (3) migrate the technology to other medical Centers around the country.

To read more about the Keaton Raphael Memorial, please click on
CBST Visits Abbott Hematology Diagnostics in Santa Clara, CA - April 2010
Dr. Stephen Lane, Chief Scientific Officer at CBST, presenting at Abbott Hematology Diagnostics on
April 20, 2010.
Abbott Hematology Diagnostics Visit April 2010
On Tuesday, April 20, 2010 four researchers (Drs. Stephen Lane, James Chan, Frank Chuang, and Zach Smith) and two members of  CBST's Knowledge Transfer Team (Dr. Amy L. Gryshuk and Mr. Tod Stoltz)  traveled down to Santa Clara, CA where Rupa Rao, PhD (Sr. Systems Engineer) and Tim Buskard, MS (Manager Systems Engineer) organized a visit at Abbott Hematology Diagnostics.  The visit provided an opportunity for Dr. Lane to present an overview of CBST and our portfolio of research projects, as well as an opportunity for Dr. Chan to present a detailed talk on his area of research (e.g. raman spectroscopy).  The CBST talks were followed up by presentations from Abbott, as well as an open discussion session.
CBST Annual Retreat Scheduled for July 2010
CBST is currently organizing their Annual Retreat, which is scheduled to be held at The Resort at Squaw Creek in Lake Tahoe, CA this July 2010.  The Center-wide retreat will be by invitation only, open to CBST faculty, graduate students, postdoctoral researchers and affiliates.  The retreat provides participants ample opportunities to interact through structured as well as open activities: invited talks, project updates, group sessions, and a technology showcase.  The focus of this year's retreat is Biophotonics in Pathology.  We will feature invited talks from 2-3 keynote speakers, CBST graduate students and postdoctoral researchers, as well as exciting activities from CBST Education and Knowledge Transfer programs.  Daily symposia and poster sessions have been arranged for participants, as well as free time for informal discussion and networking.  We're looking forward to another successful retreat! 
Please stay tuned for more updates.
Awards & Recognitions
Rui Liu Receives an Educational Scholarship in Optical Science & Engineering - May 24, 2010
Rui LiuSPIE has awarded a $2000 Educational Scholarship in Optical Science and Engineering to Rui Liu, a PhD candidate at the NSF Center for Biophotonics Science and Technology  under the supervision of Prof. Dennis Matthews and Dr. James Chan.  Mr. Liu's dissertation project is focused on developing a new in-vitro assay based on Raman spectroscopy that enables real-time, label-free monitoring of drug-induced cellular apoptosis at the single cell level. 

"In 2010 SPIE will be awarding $323,000 in scholarships to 137 outstanding students all over the world based on their potential for long-range contribution to optics and photonics, or a related discipline.  Award-winning applicants were evaluated and approved by the SPIE Scholarship Committee."

Medial contact: Stacey Crockett, Media Relations Coordinator,
G.P. McNerney, W. Hübner, B.K. Chen, and T. Huser, "Manipulating CD4+ T cells by optical tweezers for the initiation of cell-cell transfer of HIV-1", J. Biophoton. 3(4), 216 - 223 (2010).
L.J. den Hartigh, J.E. Connolly-Rohrbach, S. Fore, T.R. Huser, J.C. Rutledge, "Fatty acids from Very Low-Density Lipoprotein Lipolysis Products Induce Lipid Droplet Accumulation in Human Monocytes", J. Immunol., 184(7), 3927 - 3936 (2010).
T. Weeks, I. Schie, S. Wachsmann-Hogiu, and T. Huser, "Signal generation and Raman-resonant imaging by non-degenerate four-wave mixing under tight focusing conditions" J. Biophoton. 3(3), 169 - 175 (2010).

T.J. Weeks, and T.R. Huser, "Differential imaging of biological structures with doubly-resonant coherent anti-Stokes Raman scattering (DR-CARS)",  J. Vis. Exp. (2010), in print.

B. Dale, G.P. McNerney, D.L. Thompson, T. Huser, and B.K. Chen, "Visualizing cell-to-cell transfer of HIV using fluorescent clones of HIV and live confocal microscopy",  J. Vis. Exp. (2010), in print
Calendar of Events
June 10 - SARTA's Leadership Series Med Tech Track: Developing a Reimbursement Strategy for Your Medical Device (8:30 - 11:30 AM)
Sponsored by: Drexel University Center for Graduate Studies
Registration, breakfast and networking from  8:30 am - 9:00 am
Location: Drexel University, One Capitol Mall, Suite 260, Sacramento, CA 95814
Who Should Attend: Med Tech Inventors, Engineers, Entrepreneurs, and Decision Makers 
Cost: General Admission: $40 / SARTA Members: $25 
Price includes free parking for 4 hours at the One Capitol Mall Valet Garage on 2nd Street (valued at $8) and a continental breakfast.
For member discount code, please email [email protected].
To read more, please click on 

June 16 - SARTA's Leadership Series: How to Fund Your Small Business or Start-Up (8:30 - 11:30 AM)
Sponsored by: Drexel University Center for Graduate Studies
Registration, breakfast and networking from 8:30-9:00 a.m.
Location:Drexel University, One Capitol Mall, Suite 260, Sacramento, CA 95814
Cost: General Admission: $40 / SARTA Members: $25 
Price includes free parking for 4 hours at the One Capitol Mall Valet Garage on 2nd Street (valued at $8) and a continental breakfast.
For member discount code, please email [email protected]
To read more, please click on

June 17-18 - BioBasics 2010 - 2 Day Class / Industry Knowledge for the Non-Scientist (9:00am - 4:30pm)

Location: Latham & Watkins, 140 Scott Drive, Menlo Park, CA 94025
Cost: BayBio Members: $845; Non-Member: $945
Parking: No cost
To read more, please click on

June 29 - Mission Bay Open House and Panel Discussion (3-7 PM)

Location:UCSF Core Facilities Tours and Poster Sessions:3:00pm - 5:00pm
Panel Discussion: Mission Bay on a Mission: 5:00pm - 6:00pm
Networking Reception: 6:00 - 7:00pm
Location: UCSF Mission Bay, 1700 4th St, Byers Hall, San Francisco, CA
Parking: Garage parking available $3/hr
Attire: Business attire suggested
Cost: Tours Only: $20 BayBio Members | $40 Non-Members
Cost: Tours, Panel Discussion and Reception: $40 Members | $75 Non-Members

To read more, please click on

June 29 - TechSurge Returns - SARTA's summer networking mixer for the technology industry is here! (5 - 8 PM)
Location: M!X Downtown, 1525 L St., Sacramento CA 
Cost: Early Bird Rate - Register by Friday June 25:  General Admission $40 / SARTA Member $20
Cost: After June 25, admission prices go up to General Admission $50 / SARTA Member $25
For SARTA discount information, contact [email protected] or call 916-231-0770

To read more, please click on
Grants and Funding Opportunities
Grants of Interest & UCD Limited Submissions
For inquiries regarding grant opportunities, please contact Gabriela Lee at [email protected] or visit to learn more. 
Thank You - Please Pass Along
We'll be sending out our CBST Newsletters once/month.  Please send your comments and suggestions to [email protected].  We look forward to staying in touch and welcome news/highlights from your organization for inclusion in future newsletters.   
Please forward our CBST Newsletter along by CLICKING on the FORWARD EMAIL hyperlink at the bottom of this newsletter. 
Amy L. Gryshuk, Ph.D.
Director of New Ventures / UC Discovery Fellow
NSF Center for Biophotonics Science & Technology (CBST)
2700 Stockton Blvd., Suite 1400, Sacramento, CA 95817  
TEL (916)734-0785; FAX (916)703-5012