Work supported by the National Science Foundation
Cooperative Agreement No. PHY-0120999.
We're continuing to progress forward with our plans for Biophotonics Week this September 2010 to be held in Quebec City, Canada. Please visit our website, http://www.biophotonicsworld.org/home, for frequent updates. During the end of February we have been preparing for Dr. Arden L. Bement Jr.'s (the Director of the National Science Foundation) visit to the University of California, Davis on Friday, March 5, 2010. As part of his visit he will stop by our Center for Biophotonics for a short presentation and tour of our research laboratories. The Board of the Tahoe Institute for Rural Health Research (TIRHR) will also be visiting UC Davis in early March to discuss rural healthcare needs with the UC Davis Health System as well as spend time at CBST.
~Dennis Matthews, Ph.D. CBST Director
Meet the Researcher - Dr. Matthew Coleman
Dr. Matthew Coleman
is currently an Associate Adjunct Professor at
the University of California, Davis in the Department of Radiation Oncology
and a member of the NIH Cancer Center
within the medical center. Dr. Coleman
also holds a scientific appointment as a Senior Scientist at the Lawrence
Livermore National Laboratory in Livermore, California
Dr. Coleman's research
focuses on understanding the processes involved in genome instability following
genotoxic stresses such as ionizing radiation. Dr. Coleman's research also uses novel approaches in
nanotechnology using nanolipoproteins to help characterize biological
components involved in cell signaling.
Dr. Coleman's training is in molecular biology
where he received his B.A. from the University of Massachusetts, and his Ph.D.
in biophysical studies of membrane proteins from Boston University. He has
authored over 60 publications in peer-reviewed journals, published proceedings
and book chapters covering a diverse breadth of molecular biology and biochemistry.
Coleman has three patents and 6 patents pending related to biomarker discovery
and biotechnology. For his work in the area of nanolipoproteins -membrane
protein complexes Dr. Coleman received a Nanotechnology 50 award for
co-development of his innovative approach to produce and solubilize membrane
proteins using nanoparticles
Research projects in Dr. Coleman's laboratory include radiation biology and applications to point-of-care
detection using biosensors:- Biodosimetry
- Human genetic variation
responses to radiotherapy
His research work has been supported by several agencies including DOE, NIH and LLNL.
1. Martinez, A., Hinz, J., Gomez, L., Molina,
B., Acuna, H., Frias, S. and Coleman, M.A. (2008). Differential expression of
TP53 associated genes in fanconi anemia cells after mitomycin C and hydroxyurea
2. Cappuccio, J.A., Blanchette, C.D.,
E. S. Hinz, A.K. Chromy,
B.A. Fletcher, J., Katzen,
F., Kudlicki, W., Bench, G., Hoeprich, P.D. and
Coleman, M.A. (2008) Self-assembly of solubilized functional
integral-membrane proteins in nanolipoprotein complexes using cell-free
co-expression. Mol. Cell. Proteomics. 7, 2246-2253.
3. KatzenF. Fletcher, J., Kang, D., Peterson, T.,
Cappuccio, J.A., Blanchette, C.D., Shulchek, T., Chromy, B., Hoeprich, P.,
Coleman, M.A. and Kudlicki, W. (2008) Cell-free expression of integral membrane proteins into discoidal
Proteome Res. 7:3535-3542.
4. Narayan, S., Lehmann, J., Coleman,
M.A., Vaughan, A., Yang, C.C., Enepekides, D., Farwell, G., Purdy, J.A.,
Laredo, G. Nolan, K., Pearson, F. and Vijayakumar, S. (2008). Prospective
evaluation to establish a dose response for clinical oral mucositis in patients
undergoing head and neck conformal radiotherapy. Int J Radiat Oncol
Biol Phys. 72:756-62.
L.E. and Coleman, M.A. (2008) Machine
learning-based receiver operating characteristic (ROC) curves for crisp and
fuzzy classification of DNA microarrays in cancer research. Int
J Approx Reason.
6. Beller, H. R., Legler,
F., Letain, T. E., Kane, S.R., and Coleman, M.A. (2009).
Identification of c-type cytochromes
involved in anaerobic, bacterial U(IV) oxidation. Biodegradation. 20:45-53.
7. Blanchette, C.D., Law, R.W., Benner, H., Pesavento, B., Cappuccio, J.A.,
Walsworth, V., Kuhn, E., Corzett, M., Chromy, B., Segelke, S., Coleman, M.A.,
Bench, G., Hoeprich, P., and Sulchek, T. (2009) Quantifying size distributions of
nanolipoprotein particles (NLPs): A combined atomic force microscopy (AFM), ion
mobility spectrometry (IMS) and molecular dynamic (MD) simulation study. J
Lipid Res. 49:1420
8. Blanchette, C.D.,
Kuhn, E.A., Segelke, B.W., Coleman, M.A., Chromy, B.A., Bench, G., Hoeprich,
P.D., Sulchek, T.A. (2009) Atomic Force Microscopy Differentiates Discrete Size
Distributions between Membrane Protein Containing and Empty Nanolipoprotein
Particles. Biochimica et Biophysica Acta
- Biomembranes. 1788:724-31.
9. Thompson, D., Pearson, F., Rao, R.,
Matthews, D. Albala, A., Wachsmann-Hogiu,
S., and Coleman, M.A.
(2009) A portable hand-held microarray reader for biodetection. Sensors. 9: 2524-2537.
10. Blanchette, C.D., Segelke, B.W.,
Fischer, N., Corzett, M., Kuhn, E.A., Cappuccio, J.A., Benner, H., Coleman,
M.A., Chromy, B.A., Bench, G., Hoeprich, P.D. and Sulchek, T.A. (2009) Characterization and purification of
polydispere reconstituted lipoproteins and nanolipoprotein particles. Int J Mol Sci.
11. Baker, S.E., Hopkins, R.C.,
Blanchette, C.D., Walsworth, V.L., Sumbad, R., Fischer, N.O., Kuhn, E.A., Coleman, M.A., Chromy,
B.A., Létant, S.E., Hoeprich, P.D., Adams, M.W., and Henderson, P.T. (2009)
Active Membrane-Bound Hydrogenase Incorporation into Soluble Nanoparticles. J. Am. Chem. Soc. 22:7508-9.
12. Cappuccio, J.A. Hinz,
A.K., Kuhn, E.A. Fletcher, J., Arroyo, E.S., Henderson, P.T., Blanchette, C.D.,
Walsowrth, V.L., Corzett, M.H., Law,
R.J., Pesavento, J.B., Segelke, B.W.,
Sulchek, T.A., Chromy, B.A., Katzen, F., Peterson, T., Bench, G., Kudlicki, W.,
Hoeprich. Craig D., and Coleman, M.A. High Throughput Protein Expression
and Purification, Methods in Molecular Biology , Vol. 498, Doyle, Sharon A. (Ed.),
2009,chapt. 18, Cell-free Expression
for Nanolipoprotein Particles (NLPs): Building a High-Throughput Membrane
Protein Solubility Platform.
13. Peterson, L.E.,
Coleman, M.A. (In press) Logistic Ensembles of Random Spherical Linear
Oracles for Microarray Classification. Int. J. Data Mining and Bioinformatics.
14. Martínez, A., Blanco, B., Carnevale, A., Mora, M.A.,
Coleman, M.A. Romero-Talamás, C.A. and Frías, S. (In Press) Assessment of immediate DNA
damage to workers occupationally exposed to low dose of ionizing radiation
using the Comet Assay.
Radiation Research Society
A. Coleman Ph.D.
Oncology, Cancer Center
University of California
4501 X Street,
Sacramento, CA 95817
and Biotechnology Division
Livermore National Laboratory
|CBST Education Highlights|
CBST represented well at the Sacramento Regional Science & Engineering Fair - March 2010
In the last weekend of March
hundreds of 6th- 12th grade students representing nine Northern California counties will enter the main building of Rosemont High School for the Sacramento Regional Science and Engineering Fair (SRSEF)
. Among the group will be ten Sacramento high school students involved in CBST's Cancer Science and Biophotonics Research Academy. The science fair will be a chance for them to showcase their research in topics raging from Breast and Prostate cancer to Vitamin B17 Toxicology effects on Black worms.
The high school students are part of the Education program at CBST that links local high school students with labs, guest speakers and curriculum focusing on cancer research. The students participate for a full school year followed with a summer cancer research experience.
The Sacramento Regional Science and Engineering Fair
will also offer the students an opportunity to share their experiences with CBST, practice their presentation skills, and win scholarships and prizes. The event is free to students and the public on March 27th (free parking also)
. If you are interested in attending or volunteering please contact the fair website at http://www.srsefair.org.
CC Winter Internship Program
In January 2010
(4th-16th), twenty-four students from thirteen community colleges in Northern California participated in the third cycle of the Winter Research Program for Community College Students at CBST
(program known as 'CCWinter'). This year the program was co-facilitated by Drs. Corbacho and Gurkoff
and co-funded by CBST (NSF funds) and the UC Davis College of Biological Sciences (HHMI funds). Twenty-two of the students plan to transfer to a four-year university in 2010, of which sixteen plan to transfer to UCD as their first choice. The majority of the participants (83%) are working students, with an average of 18 work-hours per week. Participating Community Colleges
with students noted in parentheses: American River College (6), Cañada College (1), Contra Costa College (1), Consumnes River College (3), Hartnell College (1), Mendocino College (1), Merced Community College (1), Mission College (1), Napa Valley College (1), Sacramento City College (2), Skyline College (1), Solano Community College (2), Yuba College (2).
For more comments visit: http://cbst.ucdavis.edu/education/community-college/internship-community-college/2010-ccwinter-internship
Interview with a future researcher - ET-CURE program participant from CBST
Name: Laura Ramirez
Current University/School: Undergraduate
at CSU Sacramento
Lab assignment: Dr. Kit Lam
What does the ETCURE program
The ET-CURE (Engineering Technologies Continuing Umbrella Research Experiences) program is my
opportunity to do research directly related to cancer. The experience developed
from this program will strengthen my research ability and continue my
preparation to contribute to the scientific community in the search for a cure
What sparked your interest in science and specifically
As a child I was always intrigued with science. My parents enrolled me in Saturday classes
and after school programs that almost always involved science. I remember building bottle rockets, volcanoes
that erupted red slough, solar cars and ovens. At the end of those projects I
was always left with questions about the forces related to those reactions.
What are you working on now with your ET-CURE research?
am currently working on imaging bacteriophage on PVA-PEG beads with a
transmission electron microscope and scanning electron microscope in order to
visualize the orientation of binding between both. It is essential to do this in order to verify
that in fact the protein expressed on the head of the phage is actually what is
binding to the ligand on the bead.
If you where invited to talk to your grade school how would you
encourage them to pursue science/research?
I would present
them with as much statistical information showing the health disparities that
exist with minorities and cancer. I
would also present them with the data shown for underrepresented students in
the sciences. I believe this would make
a significant impact on them because the majority of the students at my Jr.
High and High School are underrepresented students.
|CBST Knowledge Transfer Highlights|
SARTA 7th Tech Index Celebration - February 17th, 2010
Members of the CBST Knowledge Transfer team (Tod Stoltz, Gabriela Lee, and Amy L. Gryshuk)
attended the 7th edition of
SARTA's Tech Index Celebration
held at the Hyatt Regency in Sacramento, whose purpose is to honor Sacramento's
leading 50 high-tech companies, foster technology and entrepreneurial
growth, and build an innovation economy. The Tech Index helps measure
and track the state of the region's economic health. Linda Katehi, UC
Davis' sixth Chancellor
, and Kevin Surace, CEO of Serious Materials and
2009 Entrepreneur of the Year
as recognized by Inc. magazine, were the
event's featured speakers.
For more details about Chancellor Katehi's address, visit: http://dateline.ucdavis.edu/dl_detail.lasso?id=12419For more information, contact Gabriela Lee, Director of Partnerships and New Program Development, at Gabriela.Lee@cbst.ucdavis.edu
SARTA MedStart: 1st Annual Sacramento Med Tech Showcase - March 30, 2010 (1:00 to 7:30 PM)
Are you a scientific researcher, a clinician, an engineer, an
entrepreneur, or an
individual interested in translating medical technologies to the market place?
Join SARTA MedStart for their 1st Annual Sacramento Med Tech Showcase - "Transforming
Medicine Through Technology". The March 30th, 2010 event will feature
industry leaders, two keynote speakers, an investor panel, a business plan
competition, the Claire Pomeroy Innovation Awards, and over 50 exhibitors. The Med Tech Showcase will be held at Sacramento State, Grand
the University Union.
find out more, visit http://www.sarta.org/go/sarta/news-events/events/sacramento-med-tech-showcase/.
So, what or who is SARTA? The Sacramento Area Regional Technology
Alliance (SARTA) was established in 2001 as a tech-focused 501(c)(3)
non-profit organization. SARTA's mission is to "accelerate the
growth and development of technology companies and the technology sector in the
Sacramento region as well as attracting venture capital to the region".
MedStart Program is a rapidly growing regional economic development
collaborative, that envisions a thriving medical device and medical technology
industry in the Sacramento region and is serving as a catalyst in making that
happen. The UC Davis Health System
along with Sutter Health Sacramento Sierra Region, Western Blue, Morrison
Foerster, and Pride Industries are MedStart's Founding Sponsors.
March 9 - BayBio's Medical Device Breakfast Series: Strategies to Expedite Revenue (8:00 - 10:00 AM)
Speaker: Jerry Gibson, Chief Executive Officer, Critical Perfusion, Inc.
Cooley Godward Kronish LLP, Palo Alto Campus, 3175 Hanover Street, Palo Alto, CA 94304
Business attire suggested
Early Bird Registration through March 7: $10.00 - BayBio & MDMA Members, Bio2Device and Bio-X Affiliates $20.00 - Non-Members.
On-Site Registration, March 10:
$20.00 - BayBio & MDMA Members, Bio2Device and Bio-X Affiliates $40.00 - Non-Members
To read more, please click on http://www.baybio.org/wt/page/Strategies_to_Expedite_Revenue_3-10-10.
March 17 - BayBio's BioEntrepreneurial Forum: 7th Annual Life Sciences Investor & Entrepreneur Roundtables (5:30-9:00 PM)
Registration: 5:30-6:00 PM
Roundtable Discussion: 6:00-9:00pm
Sheraton Palo Alto Hotel, 625 El Camino Real , Palo Alto, CA 94301
Hotel Parking Available - $2 per hour; $15 valet
Business attire suggested
Early Bird Registration through March 15th - $55
On-Site Registration, March 17th - $70
To read more, please visit http://www.baybio.org/institute/wt/page/7th_Annual_Life_Sciences_Investor___Entrepreneur_Roundtables
March 17 - SARTA's Leadership Series: Grant Writing Basics for Private Industry (8:30 - 11:30 AM)
Time: Registration, breakfast and networking from 8:30-9:00 a.m.
Location: Drexel University, One Capitol Mall, Suite 260, Sacramento, CA 95814
Cost: General Admission: $50; SARTA Members: $25 - Price includes free parking for 4 hours at the One Capitol Mall
Valet Garage on 2nd Street (valued at $8) and a continental breakfast. For member discount code, please email firstname.lastname@example.org.
To read more, please click on http://www.sarta.org/go/sarta/news-events/events/sartas-leadership-series-march-2010/
March 24 - SARTA's Leadership Series Government Tech Track: Tools and Tactics for Navigating the $78B Federal Information Technology Marketplace (8:30 - 11:30 AM)
Time: Registration, breakfast and networking from 8:30-9:00 a.m
Drexel University, One Capitol Mall, Suite 260, Sacramento, CA 95814
Cost: General Admission: $50; SARTA Members: $25 - Price includes free parking for 4 hours at the One Capitol Mall Valet
Garage on 2nd Street (valued at $8) and a continental breakfast. For member discount code, please email email@example.com
To read more, please click on http://www.sarta.org/go/sarta/news-events/events/leadership-series-government-tech-track-march-2010/
March 30 - SARTA's Sacramento Med Tech Showcase (1:00 - 7:30 PM): "Transforming Medicine Through Technology"
Join us for the 1st Annual Sacramento Med Tech Showcase featuring
industry leaders, an investor panel, a business plan competition, the
Claire Pomeroy Innovation Awards, and over 50 exhibitors.
Location: Sacramento State, Grand Ballroom in the University Union
General Admission: $80, SARTA Member $40. Full time Student or
Faculty member: $40. For SARTA discount information, contact
firstname.lastname@example.org or call 916-231-0770
To read more, please click on http://www.sarta.org/go/sarta/news-events/events/sacramento-med-tech-showcase/
|Grants and Funding Opportunities|
Grants of Interest & UCD Limited Submissions
|Thank You - Please Pass Along|
|We'll be sending out our CBST Newsletters once/month. Please send your comments and suggestions to email@example.com. We look forward to staying in touch and welcome news/highlights from your organization for inclusion in future newsletters.
Please forward our CBST Newsletter along by CLICKING on the FORWARD EMAIL hyperlink at the bottom of this newsletter.
Director of New Ventures / UC Discovery Fellow
NSF Center for Biophotonics Science & Technology (CBST)
2700 Stockton Blvd., Suite 1400, Sacramento, CA 95817
TEL (916)734-0785; FAX (916)703-5012