Work supported by the National Science Foundation
Cooperative Agreement No. PHY-0120999.
We're continuing our work to develop a sustainable Institute for biophotonics science & technology, education, and knowledge transfer, which has included discussions with our University stakeholders and the regional medical technology community. The end of January has been quite busy due to the SPIE Photonics West Conference, which was held in San Francisco, CA this year. Throughout the conference I have met with colleagues, attended our students' presentations, and hosted meetings with potential Center collaborators. Most recently this included hosting a brainstorming meeting with Biophotonics Node Leaders that will participate in our new "Biophotonics4Life Worldwide Consortium" initiative (www.biophotonicsworld.org for more information). Many thanks to all of you who paticipated in the events that took place during the month of January. We are looking forward to the activities in the coming months and are especially interested in staying abreast of the updates for "Biophotonics Week", which is scheduled to be held in Quebec City, Canada at the end of September 2010.
~Dennis Matthews, Ph.D. CBST Director
Cell Phone-based Microscopy and Spectroscopy
Modern cell phones are ubiquitous devices that are equipped with many features such as a camera to record high-quality images, the capability of transmitting data, and the ability to run applications that allow performing of complex computations previously specific for much larger computing devices. Scientists from CBST
(Drs. Sebastian Wachsmann-Hogiu, Stephen Lane, and Marco Molinaro
) have developed attachments for cell phones that have demonstrated the ability to record microscopic images with ~2 micrometers resolution.
The premise is to develop hand-held, portable disease detection and treatment monitoring tools. For instance, they have successfully recorded images of unstained and stained pathology specimens with cellular resolution, including blood smears (see image above - unstained blood smear
). These researchers have also utilized the cell phone platform to develop a spectrometer that sorts the detected light by its wavelength components (Dr. Dennis Matthews is also affiliated with this new technology).
Meet the Researcher - Dr. Sebastian Wachsmann-Hogiu
Dr. Sebastian Wachsmann-Hogiu is an Associate Professor in the Department of Pathology & Laboratory Medicine at the University of California, Davis. In addition, he holds a joint appointment as the Facilities Director of the National Science Foundation Center for Biophotonics Science & Technology at the UC Davis Medical Center in Sacramento, CA. His research interests include time-resolved Raman spectroscopy/imaging, nonlinear microscopy, and SERS-based biosensors.
Dr. Wachsmann-Hogiu holds a major in Biophysics from Bucharest University in Romania. In 2000 he received his PhD in Experimental Physics from Humboldt University/Max-Born-Institute, Berlin, where he used time-resolved Raman/CARS spectroscopy to investigate elementary chemical reactions. After two-years of a postdoctoral appointment in the Chemistry Department at Carnegie-Mellon University, where he performed Stark spectroscopy on conductive polymers and biological materials, he moved to Cedars-Sinai Medical Center as a Research Scientist I.
In March 2005, he became faculty (Assistant Professor) within the Surgery Department as well as Director of the Advanced Optical Imaging Laboratory within the Minimally Invasive Surgical Technologies Institute. It was here that Dr. Wachsmann-Hogiu became interested in translating novel optical technologies into viable tools for biomedical applications.
Research projects in Dr. Wachsmann-Hogiu's laboratory include technology development and applications to the biomedical field and renewable energies:
- Time-resolved Raman/fluorescence spectroscopy and imaging
- Plasmonics and Surface Enhanced Raman Spectroscopy (SERS)
- Biosensors and assays
- Fiber-based Raman/fluorescence endoscopes
- Point of care diagnosis
- Nonlinear microscopy
- High-resolution microscopy
- Light conversion and energy storage
His research work has been supported by several agencies including
NSF and NIH.
To read more about Dr. Wachsmann-Hogiu and his current research projects, please click on www.cbst.ucdavis.edu
. Current group members include:
Cynthia Pagba (postdoctoral researcher), Zack Smith (postdoctoral researcher), and Florian Knorr (graduate student).
Abbreviated List of Publications:
1. Wachsmann-Hogiu S. and Farkas D. L., "Nonlinear multi-spectral optical imaging microscopy: concepts, instrumentation and applications", Chapter 19 in the book "Handbook of Biological Nonlinear Optical Microscopy" in press, Oxford University Press, Editors: B. Masters and P. So.
2. S. Wachsmann-Hogiu, T. Weeks, T. Huser, "Chemical analysis in vivo and in vitro Raman spectroscopy - from single cells to humans", Current Opinions in Biotechnology, 2009, March 4-th ahead of print.
3. D. Talavera, D.C. Dafoe, T. Ng, S. Wachsmann-Hogiu, C. Castillo-Henkel, D. L. Farkas, "Enhancement of embryonic stem cell differentiation promoted by avian chorioallantoic membranes", Tissue Engineering, online ahead of print, 2009.
4. D. L. Thompson, F. Pearson, C. Thomas, R. Rao, D. Matthews, J. S. Albala, S. Wachsmann-Hogiu, M. A. Coleman, "An adaptable, portable microarray reader for biodetection", Sensors, Vol. 9, No. 4, 2009, pp. 2524-2537.
5. T. Weeks, S. Wachsmann-Hogiu, T. Huser, "Doubly-Resonant four-wave mixing (DR-FWM) microscopy with two Raman resonances", Opt. Express, Vol. 17, Issue 19, 2009, pp. 17044-17051.
6. C. V. Pagba, S. M. Lane, S. Wachsmann-Hogiu, "Raman and SERS studies of the 15-mer DNA Thrombin Binding Aptamer", Journal of Raman Spectroscopy, online ahead of print, 2009.
7. Moritz T.J., Brunberg J.A, Krol D.M., Wachsmann-Hogiu S., Lane S.M., Chan J.W., Characterization of FXTAS related isolated intranuclear protein inclusions using laser tweezers Raman spectroscopy", Journal of Raman Spectroscopy, online ahead of print, 2009.
8. T. Weeks, S. Wachsmann-Hogiu, T. Huser, "Doubly-Resonant four-wave mixing (DR-FWM) microscopy with two Raman resonances", Opt. Express, Vol. 17, Issue 19, 2009, pp. 17044-17051.
9. T. Weeks, I. Schie, S. Wachsmann-Hogiu, T. Huser, " Non-degenerate coherent anti-Stokes Raman scattering (CARS) microscopy", J. of Biophotonics, 2009, online ahead of print.
American Physical Society
American Chemical Society
NSF Center for Biophotonics Science and Technology
University of California, Davis
2700 Stockton Blvd., Suite 1400
Sacramento, CA 95817
|CBST Education Highlights|
Science Mondays on KCRA Morning News
, Education Program Coordinator for the Center for Biophotonics at UC Davis, has been working with KCRA Morning News on MY58 (Comcast Cable Channel 4) to present science segments for the Sacramento Regional Science & Engineering Fair (to be held on March 26-27, 2010). These TV segments have been presented on Monday mornings starting at 7:45 AM and will be continuing through February 15th.
The intention is that these segments will help students and parents tackle the preparation of student science projects taking them "step-by-step" to prepare a project board. Alisa will also be hosting a free workshop for teachers at the fair that will expand upon the Science Mondays concept.
To watch all the TV segments, please click on www.srsefair.org/science_mondays.htm
. If you'd like to participate or volunteer to be a judge in the Sacramento Regional Science & Engineering Fair this March 26-27th at Rosemont High School please visit www.srsefair.org
. You can also find more information on the application process as well as some of the great prizes that you could possibly win at the Fair!
|CBST Knowledge Transfer Highlights|
Biophotonics4Life Worldwide Consortium Node Leaders Meeting - San Francisco, Jan. 24, 2010
Thought leaders in biophotonics research from 19 nodes around the world met Sunday, January 24th, 2010, for the first Node Leaders Meeting of the Biophotonics4Life (BP4L) Worldwide Consortium. The meeting's main goal was to discuss the Consortium's mission, brainstorm about its goals, objectives and activities, review the Node Leaders' roles and responsibilities, all in order to achieve a consensus vision for the BP4L Worldwide Consortium.
BP4L Consortium's mission
is to connect nodes of biophotonics scientists, clinicians, educators, organizations, companies and other enthusiasts to better harness global scientific talent and resources and focus them on fundamental discovery and important end-user needs. Drs. Dennis Matthews (USA), Brian Wilson (Canada) and Juergen Popp (Europe) co-chair the Consortium; www.biophotonicsworld.org
portal is the knowledge bank for everything biophotonics that will also host social content to create and support a collaborative community.
Development of biophotonics-based standards, information dissemination about practitioners' needs (in healthcare, fundamental discovery, agriculture, and other fields), and continuous improvements of the www.biophotonicsworld.org
portal were a few specific projects important to the community that are likely to be the focus of activity for the coming year. BP4L Node Leaders and other participants will host webinars and moderate Q&A sessions on www.biophotonicsworld.org
; a calendar of events, funding sources, lectures and technical notes are other resources available or being developed on the portal for the biophotonics community worldwide.
Please stay tuned for further updates.
SARTA Leadership Series - Med Tech Track
As part of its Leadership Series, Med Tech Track, SARTA (Sacramento Area Regional Technology Alliance) hosted a seminar titled "FDA Regulatory Affairs: Medical Devices" on January 27, 2010. The seminar was a primar on FDA regulations for inventors of medical devices, focused on Quality Systems Regulations (QSR). Mary Gallup, Co-founder, President and CEO of Hantel Technologies was the main speaker, joined by Lorry Huffman, Senior Director of Regulatory Affairs at Volcano Therapeutics for Q&A at the end of the seminar.
Ana Corbacho Selected for Chancellor's Achievement Award for Diversity and Community
Dr. Ana Corbacho, an accomplished scientist and Assistant Director for Higher Education at CBST, was recently awarded the prestigious 2009-2010 Chancellor's Achievement Award for Diversity and Community. "Ana is being recognized for her achievements that contribute in substantial ways to the development and well-being of our diverse and evolving community" (UCD Press Release). She was recognized for her accomplishments at the Chancellor's reception on January 27, 2010. As an awardee Dr. Corbacho received a $500 prize.
Pictured from L to R:
Rahim Reed (Associate Executive Vice Chancellor for Campus Community Relations), Dr. Ana Corbacho, and UC Davis Chancellor Linda Katehi.
To read more about this event, please click on
Kennedy J. Reed - A Recipient of the Presidential Award for Excellence
On July 9th, 2009 the White House announced that Kennedy J. Reed, one of the original Associate Directors for Education at CBST and a theoretical physicist at Lawrence Livermore National Laboratory, had been selected as one of the winners of the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring. The recognition ceremony was held on Wednesday, January 6th, 2010. President Obama honored Kennedy and others for their role in mentoring the academic and personal development of minority students underrepresented in the studies of science or engineering. As a recipient, Kennedy was also awarded a grant of $10,000 to go towards his continued mentoring efforts. Kennedy is pictured 8th from the left and to the President's right.
*Credit: Official White House Photo by Samantha Appleton
To read more, please click on
Recent CBST Publications
1. T. Weeks, I. Schie, S. Wachsmann-Hogiu, and T. Huser. Signal generation and Raman-resonant imaging by non-degenerate four-wave mixing under tight focusing conditions. J. Biophot., DOI:10.1002/jbio. 10068, in print (2010).
February 9 - BayBio's Medical Device Breakfast Series: Company Valuation for Merger or Acquisition (8:00-10:00 AM)
Location: Cooley Godward Kronish LLP, Palo Alto Campus, 3175 Hanover Street, Palo Alto, CA
Attire: Business attire suggested
Cost: Early Bird Registration through Feb. 7: $10.00 - BayBio & MDMA Members, Bio2Device and Bio-X Affiliates; $20.00 - Non-MembersTo read more, please click on http://www.baybio.org/wt/page/Company_Valuation_For_M_A
February 11- BayBio's NEST Venture Spotlight Series: A Sweet Deal - How to Attract Investors (8:00 - 10:00 AM)
February 17 - SARTA's 2010 Tech Index Celebration Luncheon(10:30 - 1:30 PM)
Location:Hyatt Regency, 1209 L Street, Sacramento in the Regency Ballroom
Cost: Individual tickets
: $90 general, $45 for SARTA & Metro Chamber members
Table seating (table of 8): $700 general; $350 SARTA & Metro Chamber members
Exhibit table for 10:30-11:30 exhibit: $350 general and $250 for SARTA & Metro Chamber members
February 18 - SARTA's Leadership Series February 2010: How to Interest the Media in News About Your Business--featuring local media panel (8:30 - 11:30 AM)
Sponsored by: Drexel University Center for Graduate Studies
erest the Media in News About Your Business--featuring local media panel
Location:Drexel University, One Capitol Mall, Suite 260, Sacramento, CA 95814
Cost: General Admission: $50. SARTA Members: $25
February 24 - BayBio's SBIR/STTR Grant Writing Workshop (9:00 - 11:00 AM)
Location: Latham & Watkins, 140 Scott Dr., Menlo Park, CA 94025
Attire: Business attire suggested
Cost: BayBio Member Price: $20. Non Member Price: $30
Instructors: Shauna Farr-Jones and Amy Boggs
February 25 - Five Strategies to Create a Powerful Brand with Libby To read more, please click on http://www.techcoire.com/upcoming.html
|Grants and Funding Opportunities|
Grants of Interest & UCD Limited Submissions
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Director of New Ventures / UC Discovery Fellow
NSF Center for Biophotonics Science & Technology (CBST)
2700 Stockton Blvd., Suite 1400, Sacramento, CA 95817
TEL (916)734-0785; FAX (916)703-5012