Work supported by the National Science Foundation
Cooperative Agreement No. PHY-0120999.
Among other things, we have hosted visitors and paid visits to places near and far during the past few months, to promote our Center and medical technology commercialization in general. In November, I've traveled to Shanghai, China to the 2009 Asia Communications and Photonics Conference and Exhibition, where I served as a Technical Program Chair. I've also promoted our new "Biophotonics4Life Worldwide Consortium" initiative and the BiophotonicsWeek series of events scheduled for September 22-30, 2010 in Quebec, Canada. At NSF's recommendation, we've hosted visitors from AAAS at CBST, as part of a study they are conducting on the NSF Science and Technology Centers Program. Many thanks to all of you who took the time and met with our visitors.
Most recently, I participated in the House R&D Caucus, which took place on December 1st, 2009 in Washington, D.C. Along with others, I presented a talk to policy-makers about interdisciplinary science, and provided advice on how the government could focus more on accelerating healthcare innovations out of our universities. We're looking forward to continuing our work in biophotonics science & technology, education and knowledge transfer in the new year, including discussions with policy-makers regarding university-based technology commercialization.
Happy holidays and best wishes in the New Year!
~Dennis Matthews, Ph.D. CBST Director
Dr. Dennis Matthews Presents at the House R&D Caucus
On December 1, 2009 experts in the light-based scientific disciplines advised policy-makers in Washington, D.C. on how the government could help accelerate healthcare innovation
. The luncheon, sponsored by SPIE
(International Society for Optics and Photonics), invited leaders from biophotonics, nanomedicine, and bioimaging. David Benaron
(CEO of Spectros & faculty member at Stanford University), Dennis Matthews
(Director of the National Science Foundation Center for Biophotonics Science & Technology at the University of California, Davis), and Naomi Halas
(Director of the Laboratory for Nanophotonics and Professor of Biomedical Engineering, Chemistry, Physics, and Astronomy at Rice University) presented to the House R&D Caucus.
*Photo as seen on the SPIE website (http://spie.org/x38175.xml
). From left to right, presenters at the House R&D Caucus: Eugene Arthurs, CEO of SPIE (moderator); Naomi Halas; David Benaron; and Dennis Matthews.
AAAS Scientists Visit CBST
Drs. Irwin Feller, Professor Emeritus of Economics and AAAS Senior Visiting Scientist, and Edward Derrick, Director of the AAAS Research Competitiveness Program, visited CBST in November, in order to collect information for a study they are conducting on the NSF Science and Technology Centers (STC) Program. They met with faculty, researchers, students, and other Center constituents, and discussed in detail about CBST's programs, accomplishments and future plans. During their extended study that includes visits to 5 STCs and phone interviews with representatives from all current STCs, Drs. Feller and Derrick aim to capture the NSF Science & Technology Centers Program value-add, both in quantitative and qualitative terms. We will share the findings of their study with the CBST community when it becomes available.
Meet the Researcher - Dr. Kit Lam
Dr. Kit Lam
was born in Hong Kong, obtained his B.A. in Microbiology in 1975 at the University of Texas at Austin, where he received a Robert A Welch Undergraduate Research Fellowship in 1974-75. He obtained his Ph.D. in Oncology in 1980 from McArdle Laboratory for Cancer Research, University of Wisconsin, and his M.D. in 1984 from Stanford University School of Medicine. He completed his Internal Medicine residency training and Medical Oncology Fellowship training at the University of Arizona. He is board certified in both Internal Medicine and Medical Oncology. He was on the faculty of the University of Arizona until June 1999, when he joined UC Davis School of Medicine as the Division Chief of Hematology/Oncology
, a position he continues to hold today. He is both a practicing medical oncologist and a laboratory investigator. Dr. Lam is recognized as one of the three pioneers (in addition to Mario Geysen and Richard Houghten) who started the field of synthetic combinatorial chemistry in the late 1980s and early 1990s.
His expertise is on the development and application of combinatorial chemistry and other chemical methods to solve biomedical problems. Dr. Kit Lam conceived the "one-bead-one-compound" (OBOC) concept to generate huge chemical libraries. With the help of his mentor, the late Dr. Sidney Salmon (Director of the Arizona Cancer Center) and other colleagues at the University of Arizona, he was able to reduce the OBOC combinatorial library method to practice, filed the patent, and published the technique in Nature in 1991. This represents one of the first few reports in the new field of combinatorial chemistry at the time. Since then, the field of combinatorial chemistry has rapidly evolved into a new chemistry discipline, and four scientific journals are now devoted to this field (J of Combinatorial Chemistry, Combinatorial Chemistry and Highthroughput Screening, Molecular Diversity, and QSAR Combinatorial Science). Combinatorial chemistry has become an indispensable tool in drug development and chemical research. The OBOC combinatorial library approach is unique and truly an ultra-high throughput method, as thousands to millions of chemical compounds (peptides, peptidomimetics, small molecules, and macrocyclic natural product like molecules) can be efficiently synthesized and screened in parallel in a relatively short time. Many investigators around the world have successfully applied the OBOC methods to their research, ranging from basic research to drug discovery to biosensor to catalysis to material science. Since its publication in 1991, the Lam paper on OBOC method has been cited over 1,100 times.
Members of Dr. Lam's group include:
Nasir Al-Awaad, Lorenzo Berti, Urvashi Bhardwaj, Chou-Yu 'Joy' Chen, Florin Despa, Gabriel Fung, Yuanpei Li, Pappanaicken Kumaresan, Ruiwu 'Ray' Liu, Juntao Luo, Anthony Maida, Devin McNally, Liping Meng, David Olivos, Ekama Onofiok, Mary Saunders, Jared Townsend, Don-Hong Wang, Yan Wang, Zhaoju 'Daisy' Wu, Chun-Yi 'Jimmy' Wu, Kai Xiao, Wenwu Xiao, and Nianhuan Yao. (http://oboc.ucdavis.edu/html/members.htm)
Selected Publications (5/240):
1. Lam KS, Salmon SE, Hersh EM, Hruby V, Kazmierski WM, Knapp RJ: A new type of synthetic peptide library for identifying ligand-binding activity. Nature 354(7):82-84, 1991 (Seminal paper that first described the one-bead one-compound combinatorial library method; it has been cited over 1100 times).
2. Sun YS, Landry JP, Fei YY, Zhu XD, Luo JT, Wang XB, Lam KS. Macromolecular scaffolds for immobilizing small molecule microarrays in label-free detection of protein-ligand interactions on solid support. Anal Chem, 81: 5373-5380, 2009.
3. Yao N, Xiao W, Wang X, Marik J, Park SH, Takada Y, Lam KS. Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method. J Med Chem 52: 126-133, 2009.
4. Saegusa J, Yamaji S, Ieguchi K, Wu CY, Lam KS, Liu FT, Takada YK, Takada Y. The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphaVbeta3 is involved in IGF-1 signaling. J Biol Chem. 2009.
5. Xiao K, Luo J, Fowler W, Li Y, Lee JS, Xing L, Cheng RH, Wang L and Lam KS. A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer. Biomaterial 30:6006-6016, 2009.
Patents and Patents Pending
UC Case # Title
2004-325-0 Ligands for Alpha-4-Beta-1 Integrin
2001-150-0 Novel Method for Screening Combinatorial Libraries
2006-483-0 Chemical Antibodies for Immunotherapy
2009-700-0 Three-Dimensional Cell Adhesion Matrix
2009-219-0 Small Molecule Inhibitors of P21
2008-120-0 Small Molecule Inhibitors of AO
2001-490-0 Epithelial Cancer Ligands and Assays
2008-640-0 A Novel Compound that Activates the Antioxidant Response Element
2009-506-0 A New Class of Anti-Cancer and Anti-Inflammatory Agents
Meet the CBST Postdocs
Dr. Zach Smith
graduated from the Institute of Optics at the University of Rochester in April of this year. His thesis was titled "Integrated Raman and Angular Scattering of Single Biological Cells" and he was supervised by Prof. Andrew Berger. Zach joined CBST in November 2009 and is currently working with Drs. Sebastian Wachsmann-Hogiu and Thomas Huser on time-gated Raman scattering and Raman cytometry.
Dr. Kaiqin Chu
graduated from the Institute of Optics at the University of Rochester in 2009. Her thesis was titled "Partition Lenses for Extended Depth of Field". At CBST, Dr. Chu will work on two projects: (1) An X-ray related project where she will perform simulations and have access to the X-ray lasers at Stanford University and (2) a second project that will involve utilization of the OMX microscope.
|CBST Education Highlights|
Society for the Advancement of Chicanos and Native Americans in Science (SACNAS)
In mid-October, sixteen interns from the CBST Summer 2009 undergraduate research program, including all nine of the ET CURE interns (a joint CBST/UCD Cancer Center program), attended the annual conference of the Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) in Dallas. The majority of interns received travel awards to offset the costs of attending the conference. At the conference, the interns listened to presentations by leading scientists, attended career development workshops, explored funding opportunities and graduate programs at the exhibit booths, and enjoyed opportunities to socialize with the over 2700 participants (a conference record!). They also presented their own research in poster sessions. The mentors prepared the interns well; all received positive feedback on their work. Three interns received awards for their presentations: Leah Meza, Ngabo Nzigira, and Joyce Wong. In addition, the interns helped staff the UC Davis/CBST recruitment booth; demonstrating light matter interactions with gummy bears and lasers, answering questions about the CBST summer internship program, and promoting summer programs for teachers. Marco Molinaro and Jodie Galosy, who accompanied the students, gave a workshop for teachers on biophotonics activities for the classroom. Molinaro also organized a cross STC (Science & Technology Center) presentation on the conference theme of interdisciplinary science.
Science & Technology Center (STC) Educator's Conference
The STC Educator's Conference, funded by a grant from the National Science Foundation, took place October 14-15 in Dallas, prior to the SACNAS conference. The purpose of the conference was to explore collaborations that would strengthen the impact of STCs on K-20 STEM education. Marco Molinaro and Jodie Galosy, from the CBST Education Team, co-chaired the conference and met with a planning committee to develop the conference agenda. Tania Miller, CBST Executive Assistant to the Director & Sr. Management, coordinated conference logistics and was available on site to provide support during the conference.
Twenty-five (25) people, representing twelve STCs, attended the conference. Conference activities included an introductory poster session where participants highlighted their center's educational programs, several presentations by invited speakers, and brainstorming/working sessions to identify and develop joint proposals of mutual interest. The working sessions resulted in initial drafts of three major proposals: a workshop to develop a joint STC REU evaluation, a survey of teacher professional development in STCs, and a plan for developing portable, affordable technologies for networking and data collection. The attendees gave the conference high marks, appreciated the opportunity to network with other STC educators, and recommended future working conferences on specific topics of interest to STC educators.
Annual Meeting of the California Science Teachers Association
Jodie Galosy and Michael Wright represented CBST Education at the annual meeting of the California Science Teachers Association, October 22-25, in Palm Springs, CA. A record number of teachers stopped by the CBST booth for demos of biophotonics classroom activities, signed up to have their IR camera photo emailed to them, and learned more about CBST teacher professional development programs. Galosy and Wright also gave a workshop, which was well received by the 25+ participants, on how biophotonics activities can help students get excited about learning state science standards related to the eye and light.
|CBST Knowledge Transfer Highlights|
Dragons' Den* - Entrepreneurship Brown Bag Discussion Series: "What Does It Take? Regulatory Approvals for Drugs and Medical Devices"
For the November 12th brown bag meeting, CBST hosted Dr. George Cimino, an R&D executive with 23 years of experience in drug/medical device and PCR diagnostic areas, who talked about the regulatory approvals for drugs and medical devices in the US. Along with covering the FDA's regulatory processes, Dr. Cimino covered the context of organizational and operational modus operandi for commercial entities and how they differ from those of academia, as well as career pathways in industry.
*Named after the television program where entrepreneurs pitch their ideas to investors (dragons), the Dragons' Den series at CBST is designed to spur discussions about medical technology commercialization and entrepreneurship.
2009 National SBIR/STTR Conference
The 2009 National Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Conference took place in Reno, Nevada from November 2-5, 2009. Dr. Amy L. Gryshuk, the Director of New Ventures from CBST, attended the conference and hosted an exhibit table with informational packets from CBST. The conference attracted contractors and companies (both early- and late-stage) seeking partnerships.
"Making Sacramento a Hotbed of Healthcare Technology: Lessons to Learn from Minneapolis" - SARTA MedStart Event in Rancho Cordova, CA
A few members of the CBST community attended a MedStart Lecture Series event on Dec. 4th that included a panel of speakers from the Minneapolis area, as detailed below. Dr. Arthur Erdman, P.E., the Richard C. Jordan Professor and a Morse Alumni Distinguished Teaching Professor of Mechanical Engineering, talked about the Medical Device Center he directs at the University of Minnesota. Mr. Joe Hofmeister of the same university's Office for Technology Commercialization, shared with the audience from his vast experience and his office's strategy in technology licensing and commercialization. Last but not least, an experienced medical device executive and entrepreneur from Minneapolis, Mr. Wally Danielson, talked about the trials and tribulations of leading a small company (Impres Medical Inc.) as its CEO.
The three panelists also visited CBST and engaged in lively and open discussions with scientists, researchers, graduate students, and management of the Center about strategies for university-based medical technology commercialization.
Recent CBST Publications
1. Wachsmann-Hogiu, S., Weeks, T. & Huser, T. Chemical analysis in vivo and in vitro by Raman spectroscopy-from single cells to humans. Current Opinion in Biotechnology 20, 63-73 (2009).
2. Weeks, T., Wachsmann-Hogiu, S. & Huser, T. Raman Microscopy based on Doubly-Resonant Four-Wave Mixing (DR-FWM). Opt. Express 17, 17044-17051 (2009).
3. Zawadzki, R.J., Choi, S.S., Fuller, A.R., Evans, J.W., Hamann, B. & Werner, J.S. Cellular resolution volumetric in vivo retinal imaging with adaptive optics-optical coherence tomography. Opt. Express 17, 4084-4094 (2009).
January 7 - UCSF QB3 - "The value of versatility for an engineer leading a startup," Shyam Patel, Nanonerve, Inc. (8:00-9:00 PM)
Location: UCSF, Byers Hall, Room 212
To read more, please click on http://qb3.org/.
January 8 - UCSF QB3 - "Angel investment in high tech," Daniel Joensen, Jetty Capital (8:00 - 9:00 PM)
Location: Stanley Hall Room 621
January 14 - The Liquidity Event (5:30 - 7:30 PM)
Location: The Hyatt Regency Sacramento 1209 L Street, Sacramento CA
Cost: early bird: $75, after January 10th: $90, at the door: $100
To read more, please click on
January 22 - Predictions 2009: Tech, Green & More (6 - 8:30 PM)
Locations: Sacramento Marriott, 11211 Point East Drive, Rancho Cordova, CA
Cost: Members free; Guests - $60 online (or $70 at the door)
Networking & Reception: 6:00 to 7:00 PM
Panel Discussion: 7:00 - 8:30 PM
To read more, please click on
January 27 - Executive Series CEO Reception with Dr. Mary Haak-Frendscho President & CSO Takeda San Francisco (5:00 - 7:00 PM)
Location: Takeda San Francisco, Inc., 285 East Grand Ave., South San Francisco, CATo read more, please click on
Parking: Free garage parking
Attire: Business attire suggested
Attendance: RSVP by January 13 is required and no registrations will be accepted at the site of the event. Open to C-Suite Executives of Life Sciences Companies Only.
Cost: BayBio Members - FREE; Non-Members - $50.00
January 28 - Therapeutic Breakfast Series - Planning for Success: Adaptive Clinical Trial Design and Implementation (8 - 10 AM)
Location: Wells Fargo Insurance Services Inc., 305 Walnut Street, Redwood City, CA 94063
Parking: Free parking
Attire: Business attire suggested
Cost: Early Bird Registration through Jan. 26: $10.00 - BayBio Members; $20.00 - Non-Members
On-Site Registration, Jan. 28: $20.00 - BayBio Members; $40.00 - Non-Members
To read more, please click on http://www.baybio.org/wt/page/Clinical_Trials_Domestic.
|Grants and Funding Opportunities|
Grants of Interest & UCD Limited Submissions
|Thank You - Please Pass Along|
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Director of New Ventures / UC Discovery Fellow
NSF Center for Biophotonics Science & Technology (CBST)
2700 Stockton Blvd., Suite 1400, Sacramento, CA 95817
TEL (916)734-0785; FAX (916)703-5012